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Source: AAPS PharmSciTech
Drug: Polyethylene Glycol
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Total 55 results found since Jan 2013.
Development of Lipid Polymer Hybrid Drug Delivery Systems Prepared by Hot-Melt Extrusion
This study sought to develop polymer-lipid hybrid solid dispersions containing the poorly soluble drug lopinavir (LPV) by hot-melt extrusion (HME). Hence, the lipid and polymeric adjuvants were selected based on miscibility and compatibility studies. Film casting was used to assess the miscibility, whereas thermal, spectroscopic, and chromatographic analyses were employed to evaluate drug-excipient compatibility. Extrudates were obtained and characterized by physicochemical tests, including in vitro LPV dissolution. Preformulation studies led to select the most appropriate materials, i.e., the polymers PVPVA and Soluplus®...
Source: AAPS PharmSciTech - July 19, 2023 Category: Drugs & Pharmacology Authors: Fritz Eduardo Kasbaum Danilo Monteiro de Carvalho La ís de Jesus Rodrigues Gleidson Cardoso Ludmila Alvim Gomes Pinho Felipe Terra Martins Marcilio Cunha-Filho Steph ânia Fleury Taveira Ricardo Neves Marreto Source Type: research
Development of 3D DLP Printed Sustained Release Ibuprofen Tablets and Their Pharmacokinetic Evaluation in Rats
The objective of the present study was to develop digital light processing (DLP) 3D printed sustained release ibuprofen (IBU) tablets using 3D DLP printers for evaluation in in vitro release and in vivo pharmacokinetic studies with their in vitro-in vivo correlation. The resin formulation and printing parameters were optimized using quality by design (QbD) approach, and IBU tablets were printed using DLP printers which works at 385 and 405 nm wavelengths. Our results demonstrated that formulation consisting of polyethylene glycol diacrylate (PEGDA) 700, water, IBU, and riboflavin printed at 40-s bottom layer exposure time ...
Source: AAPS PharmSciTech - March 28, 2023 Category: Drugs & Pharmacology Authors: Keb Mosley-Kellum Arvind Bagde Shawn Spencer Satyanarayan Dev Mandip Singh Source Type: research
Enhanced Influenza Immunity by Nasal Mucosal Administration of the TPGS-Modified Liposomal Vaccine
AAPS PharmSciTech. 2022 Sep 30;23(7):272. doi: 10.1208/s12249-022-02425-3.ABSTRACTInfluenza infection is difficult to prevent, control, and treat because of rapid viral mutation, fast disease progression, and high mortality. Vaccination is the main means by which to prevent and control influenza, but effectiveness is limited in that poor cellular uptake and weak immunogenicity of vaccines provides less than optimal host protection. Liposomal influenza vaccines are a promising strategy to overcome these limitations and the use of liposomal immune modulators and intranasal administration of liposomal influenza vaccines may b...
Source: AAPS PharmSciTech - September 30, 2022 Category: Drugs & Pharmacology Authors: Shijie Ma Rui Yu Yaping Mai Na Yu Ting Gao Jianhong Yang Source Type: research
Fabrication of TPGS-Grafted Polyamidoamine Dendrimer for Enhanced Piperine Brain Delivery and Pharmacokinetics
AAPS PharmSciTech. 2022 Aug 24;23(7):236. doi: 10.1208/s12249-022-02393-8.ABSTRACTPiperine (PIP) is a neuroprotective phytomedicine that has profound acetylcholine esterase and reactive oxygen species inhibition effect in Alzheimer's disease (AD) model. However, the oral delivery of PIP is limited by poor aqueous solubility and low bioavailability in systemic circulation. To improve the PIP bioavailability, the polyamidoamine (PAMAM) G4 dendrimer is grafted with tocopheryl polyethylene glycol succinate-1000 (TPGS) through carbodiimide chemistry to form TPGS-PAMAM conjugate. The TPGS-PAMAM coupling was confirmed through pro...
Source: AAPS PharmSciTech - August 24, 2022 Category: Drugs & Pharmacology Authors: Ajit Singh Akshada Mhaske Rahul Shukla Source Type: research
Lipid- and TPGS-Based Core-Shell-Type Nanocapsules Endowed with High Paclitaxel Loading and Enhanced Anticancer Potential
AAPS PharmSciTech. 2022 Aug 24;23(7):238. doi: 10.1208/s12249-022-02389-4.ABSTRACTThe current study elucidates the improved drug loading of paclitaxel (PTX) in lipid- and D-α-tocopheryl polyethylene glycol succinate (TPGS)-based core-shell-type lipid nanocapsules (PTX-TPGS-LNC) for augmenting the therapeutic efficacy and curbing the toxicity. PTX-TPGS-LNCs were formulated by employing anti-solvent precipitation technique and displayed a particle size of 162.1 ± 4.70 nm and % practical drug loading of 15.04 ± 2.44%. Electron microscopy revealed that PTX-TPGS-LNCs have spherical morphology and the inner core was surrounde...
Source: AAPS PharmSciTech - August 24, 2022 Category: Drugs & Pharmacology Authors: Sameer S Katiyar Ravindra Patil Rohan Ghadi Kaushik Kuche Varun Kushwah Chander Parkash Dora Sanyog Jain Source Type: research
Fabrication of TPGS-Grafted Polyamidoamine Dendrimer for Enhanced Piperine Brain Delivery and Pharmacokinetics
AAPS PharmSciTech. 2022 Aug 24;23(7):236. doi: 10.1208/s12249-022-02393-8.ABSTRACTPiperine (PIP) is a neuroprotective phytomedicine that has profound acetylcholine esterase and reactive oxygen species inhibition effect in Alzheimer's disease (AD) model. However, the oral delivery of PIP is limited by poor aqueous solubility and low bioavailability in systemic circulation. To improve the PIP bioavailability, the polyamidoamine (PAMAM) G4 dendrimer is grafted with tocopheryl polyethylene glycol succinate-1000 (TPGS) through carbodiimide chemistry to form TPGS-PAMAM conjugate. The TPGS-PAMAM coupling was confirmed through pro...
Source: AAPS PharmSciTech - August 24, 2022 Category: Drugs & Pharmacology Authors: Ajit Singh Akshada Mhaske Rahul Shukla Source Type: research
Lipid- and TPGS-Based Core-Shell-Type Nanocapsules Endowed with High Paclitaxel Loading and Enhanced Anticancer Potential
AAPS PharmSciTech. 2022 Aug 24;23(7):238. doi: 10.1208/s12249-022-02389-4.ABSTRACTThe current study elucidates the improved drug loading of paclitaxel (PTX) in lipid- and D-α-tocopheryl polyethylene glycol succinate (TPGS)-based core-shell-type lipid nanocapsules (PTX-TPGS-LNC) for augmenting the therapeutic efficacy and curbing the toxicity. PTX-TPGS-LNCs were formulated by employing anti-solvent precipitation technique and displayed a particle size of 162.1 ± 4.70 nm and % practical drug loading of 15.04 ± 2.44%. Electron microscopy revealed that PTX-TPGS-LNCs have spherical morphology and the inner core was surrounde...
Source: AAPS PharmSciTech - August 24, 2022 Category: Drugs & Pharmacology Authors: Sameer S Katiyar Ravindra Patil Rohan Ghadi Kaushik Kuche Varun Kushwah Chander Parkash Dora Sanyog Jain Source Type: research
Design of a Personalized Nasal Device (Matrix-Piston Nasal Device, MPD) for Drug Delivery: a 3D-Printing Application
AAPS PharmSciTech. 2022 Jul 28;23(6):205. doi: 10.1208/s12249-022-02351-4.ABSTRACTThe purpose of the current study is the development and the in vitro evaluation of a novel device for the nasal delivery of biodegradable polymeric films. The Matrix-Piston nasal Device (MPD) was designed and then printed employing Fused Deposition Modeling. Particularly, the CAD model of MPD was produced considering the human anatomical features of the nasal cavity and aiming to deliver the formulation on the olfactory region. The device consists of two independent parts constructed by different materials. For the 3D-printing process, differ...
Source: AAPS PharmSciTech - July 27, 2022 Category: Drugs & Pharmacology Authors: Ioanna-Maria Menegatou Paraskevi Papakyriakopoulou Dimitrios M Rekkas Paraskevas Dallas Georgia Valsami Source Type: research
Fabrication and Characterization of Buccal Film Loaded Self-emulsifying Drug Delivery System containing Lysiphyllum strychnifolium Stem Extracts
This study aimed to prepare buccal film for L. strychnifolium stem extracts. These extracts were less soluble in water and were therefore loaded in self-emulsifying systems before being mixed into the film. Astilbin was selected as a chemical marker in L. strychnifolium stem extracts. Firstly, the L. strychnifolium stem extracts were entrapped in the self-emulsifying systems which were designed and optimized based on 32 factorial design. The optimal formulation was 0.60 g of surfactant-co-surfactant mixture (Tween® 80 and polyethylene glycol 400 in the ratio of 7.5:1) and 0.40 g of caprylic/capric triglyceride. Secondly, ...
Source: AAPS PharmSciTech - July 13, 2022 Category: Drugs & Pharmacology Authors: Wiwat Pichayakorn Chaowalit Monton Yupaporn Sampaopan Kamon Panrat Jirapornchai Suksaeree Source Type: research
