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Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53.
Abstract Fluoxetine, a selective serotonin reuptake inhibitor, exerts neuroprotective effects in a variety of neurological diseases including stroke, but the underlying mechanism remains obscure. In the present study, we addressed the molecular events in fluoxetine against ischemia/reperfusion-induced acute neuronal injury and inflammation-induced neuronal apoptosis. We showed that treatment of fluoxetine (40 mg/kg, i.p.) with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tMCAO) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke mode...
Source: Neuropharmacology - March 11, 2016 Category: Drugs & Pharmacology Authors: Shan H, Bian Y, Shu Z, Zhang L, Zhu J, Ding J, Lu M, Xiao M, Hu G Tags: Neuropharmacology Source Type: research