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Metformin for the treatment of breast cancer: protocol for a scoping review of randomised clinical trials
Introduction Innovation through the repurposing of generic drugs encloses several advantages when compared with the process of developing new drugs from scratch. Metformin is an established and inexpensive antidiabetic drug for which anticancer properties have been hypothesised. A systematic review of observational studies found promising results for metformin related to breast cancer in women with diabetes. Although the number of randomised clinical trials of metformin for the treatment of breast cancer increased over the last decades, the overall landscape of those studies in this heterogeneous field remains unclear. Hen...
Source: BMJ Open - August 9, 2021 Category: General Medicine Authors: Araujo, C. F. M., Nunes, L. C., Murta-Nascimento, C., Souza, C. d. P., Bragagnoli, A. C., Fukushima, F. B., Vidal, E. I. d. O. Tags: Open access, Oncology Source Type: research

Metformin for endometrial hyperplasia: a Cochrane protocol
Introduction Endometrial hyperplasia is a precancerous lesion of the endometrium, commonly presenting with uterine bleeding. If managed expectantly, it frequently progresses to endometrial carcinoma, rates of which are increasing dramatically worldwide. However, the established treatment for endometrial hyperplasia (progestogens) involves multiple side effects and leaves the risk of recurrence. Metformin is the most commonly used oral hypoglycaemic agent in type 2 diabetes mellitus. It has also been linked to the reversal of endometrial hyperplasia and may therefore contribute to decreasing the prevalence of endometrial ca...
Source: BMJ Open - August 15, 2016 Category: Journals (General) Authors: Clement, N. S., Oliver, T. R. W., Shiwani, H., Saner, J. R. F., Mulvaney, C. A., Atiomo, W. Tags: Open access, Oncology, Research methods, Obgyn Protocol Source Type: research