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Impact of biological agents and tofacitinib for moderate-to-severe ulcerative colitis on health-related quality of life: a protocol for a network meta-analysis
Introduction In the past few years, several options have been proposed as alternative and more effective therapeutic drugs for moderate-to-severe ulcerative colitis (UC), such as biological agents and tofacitinib. Most of the clinical studies related to UC aimed to evaluate the efficacy of the drugs on clinical outcomes such as disease activity and side effects. This review aims to compare the impact of infliximab, adalimumab, golimumab, ustekinumab, vedolizumab and tofacitinib for moderate-to-severe UC on health-related quality of life (HRQoL), thereby guiding clinical treatment and scientific research of this disease. M...
Source: BMJ Open - December 30, 2021 Category: General Medicine Authors: Ma, X., Xu, H., Zhang, D. Tags: Open access, Gastroenterology and hepatology Source Type: research

Risk of tuberculosis in patients treated with TNF-{alpha} antagonists: a systematic review and meta-analysis of randomised controlled trials
Conclusions Findings from our meta-analysis indicate that the risk of TB may be significantly increased in patients treated with TNF-α antagonists. However, further studies are needed to reveal the biological mechanism of the increased TB risk caused by TNF-α antagonists treatment.
Source: BMJ Open - March 22, 2017 Category: Journals (General) Authors: Zhang, Z., Fan, W., Yang, G., Xu, Z., Wang, J., Cheng, Q., Yu, M. Tags: Open access, Evidence based practice, Infectious diseases, Pharmacology and therapeutics, Rheumatology Research Source Type: research