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Infectious Disease: Tuberculosis
Drug: Acetylcysteine
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Total 6 results found since Jan 2013.
The promises and limitations of < em > N- < /em > acetylcysteine as a potentiator of first-line and second-line tuberculosis drugs
Antimicrob Agents Chemother. 2021 Feb 22:AAC.01703-20. doi: 10.1128/AAC.01703-20. Online ahead of print.ABSTRACTN-acetylcysteine (NAC) is most commonly used for the treatment of acetaminophen overdose and acetaminophen-induced liver injury. In patients infected with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), NAC is given to treat hepatotoxicity induced by TB drugs. We had previously shown that cysteine, a derivative of NAC, potentiated the activity of isoniazid, a first-line TB drug, by preventing the emergence of INH resistance and persistence in M. tuberculosis in vitro. Herein, we demonstrate ...
Source: Antimicrobial Agents and Chemotherapy - February 23, 2021 Category: Microbiology Authors: Catherine Vilch èze William R Jacobs Source Type: research
