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Source: Archives of Toxicology
Drug: Acetylcysteine
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Total 31 results found since Jan 2013.
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) protects hair cells from cisplatin-induced ototoxicity in vitro: possible relation to the activities of p38 MAPK signaling pathway
Arch Toxicol. 2023 Aug 22. doi: 10.1007/s00204-023-03588-z. Online ahead of print.ABSTRACTThe 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) gene encodes rate-limiting enzyme in cholesterol biosynthesis, which is related to cell proliferation and mitochondrial function. The present study was designed to explore the expression of HMGCR in murine cochlear hair cells and HEI-OC1 cells and the possible mechanisms underpinning the actions of HMGCR in cisplatin-induced ototoxicity, with special attention given to p38 mitogen-activated protein kinase (MAPK) activities in vitro. The expressions of HMGCR, p-p38, ...
Source: Archives of Toxicology - August 23, 2023 Category: Toxicology Authors: Yanan Li Huiming Yang Huiming Nong Fan Wang Yajie Wang Yue Xu Junhong Zhang Hao Zhao Zhixin Cao Qianqian Yang Jianfeng Li Source Type: research
Ecstasy metabolites and monoamine neurotransmitters upshift the Na < sup > + < /sup > /K < sup > + < /sup > ATPase activity in mouse brain synaptosomes
This study demonstrates the ability of MDMA metabolites, monoamine neurotransmitters, L-Dopa and DOPAC to alter the Na+/K+ ATPase function. This could represent a yet unknown mechanism of action of MDMA and its metabolites in the brain.PMID:36104498 | DOI:10.1007/s00204-022-03370-7
Source: Archives of Toxicology - September 14, 2022 Category: Toxicology Authors: Daniel Jos é Barbosa Jo ão Paulo Capela Lu ísa Maria Ferreira Paula S ério Branco Eduarda Fernandes Maria de Lourdes Bastos F élix Carvalho Source Type: research
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts
Arch Toxicol. 2022 Sep 4. doi: 10.1007/s00204-022-03372-5. Online ahead of print.ABSTRACTThe persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen or Paracetamol, abbreviated as APAP) as the most common cause of acute liver failure in the United States, despite the availability of N-acetylcysteine, illustrates the clinical relevance of additional therapeutic approaches. While human mesenchymal stem cells (MSCs) have shown protection in mouse models of liver injury, the MSCs used are generally not cleared for human use and it is unclear whether these effects are due to xenotransplantation. Here w...
Source: Archives of Toxicology - September 4, 2022 Category: Toxicology Authors: David S Umbaugh Rupal P Soder Nga T Nguyen Olamide Adelusi Dakota R Robarts Ben Woolbright Luqi Duan Sunil Abhyankar Buddhadeb Dawn Udayan Apte Hartmut Jaeschke Anup Ramachandran Source Type: research
Compromised blood-bile barrier after acetaminophen overdose
Arch Toxicol. 2022 Jul 18. doi: 10.1007/s00204-022-03335-w. Online ahead of print.ABSTRACTN-acetylcysteine (NAC) is the only approved drug for the treatment of acetaminophen (APAP) intoxication. A limitation of NAC is the short therapeutic time-window as it is only effective within approximately eight hours after APAP ingestion, which is critical since patients seek medical attention often after the onset of symptoms approximately 24 h after overdose. Recently, a so far unknown mechanism was identified by which APAP causes an increase of intracellular bile acid concentrations in hepatocytes to concentrations that exceed cy...
Source: Archives of Toxicology - July 18, 2022 Category: Toxicology Authors: Aya A Abbas Amira Hamdy Ahmed Ezzat Ahmed Source Type: research
Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage
Arch Toxicol. 2022 Mar 28. doi: 10.1007/s00204-022-03267-5. Online ahead of print.ABSTRACTNeonicotinoids are the most widely used pesticides in the world. However, research studies have shown that it can affect the cognitive abilities and health of non-target bees and other wild pollinators by inducing DNA damage, apoptosis and mitochondrial damage, injure to its central nervous system, and it is even developmentally neurotoxic to mammals and humans, with mitochondria being an important target of neonicotinoids. Therefore, this article reviews the role of mitochondrial morphology, calcium ions (Ca2+) homeostasis, respirato...
Source: Archives of Toxicology - March 28, 2022 Category: Toxicology Authors: Xiaoqing Xu Xiaohui Wang Yaqin Yang Irma Ares Marta Mart ínez Bernardo Lopez-Torres Mar ía-Rosa Martínez-Larrañaga Xu Wang Arturo Anad ón Mar ía-Aránzazu Martinez Source Type: research
Imatinib-induced hepatotoxicity via oxidative stress and activation of NLRP3 inflammasome: an in vitro and in vivo study
Arch Toxicol. 2022 Feb 22. doi: 10.1007/s00204-022-03245-x. Online ahead of print.ABSTRACTImatinib (IM), a milestone drug used in the field of molecular targeted therapy, has been reported to cause serious adverse liver effects, including liver failure and even death. Immune-mediated injury and mitochondrial dysfunction are involved in drug-induced liver injury. However, the mechanism of IM-induced hepatotoxicity remains unclear and warrants further study. In our study, Sprague Dawley rats were administered IM by gavage with 50 mg/kg body weight (BW) once daily for 10 days. Drug-induced liver injury accompanied by inflamma...
Source: Archives of Toxicology - February 22, 2022 Category: Toxicology Authors: Feng-Ru Huang Wen-Tong Fang Zi-Ping Cheng Ye Shen Dun-Jian Wang Yong-Qing Wang Lu-Ning Sun Source Type: research
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPAR γ pathways in H9c2 cardiomyocytes
Arch Toxicol. 2022 Jan 27. doi: 10.1007/s00204-022-03225-1. Online ahead of print.ABSTRACTIncreasing exploration of rare-earth elements (REEs) has resulted in a high REEs' exposure risk. Owing to their persistence and accumulation of REEs in the environment, their adverse effects have caused widespread concern. However, limited toxicological data are available for the adverse effects of yttrium (Y) and its underlying mechanisms of action. In the present study, H9c2 cardiomyocytes were used in vitro model to investigate the cardiotoxicity of yttrium chloride (YCl3). Results show that YCl3 treatment resulted in reactive oxyg...
Source: Archives of Toxicology - January 28, 2022 Category: Toxicology Authors: Liang Xiong Jinyu Huang Sihui Wang Qiong Yuan Dongmei Yang Zuobing Zheng Yangna Wu Chunmei Wu Yanfang Gao Lijun Zou Gonghua Hu Source Type: research
