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Risk for neonatal hypoglycaemia and bradycardia after beta-blocker use during pregnancy or lactation: a systematic review and meta-analysis protocol
Introduction Beta-blockers are often used during pregnancy to treat diseases such as pre-existing hypertension, arrhythmias or pregnancy-related hypertension. Since beta-blockers are able to cross the placenta and can pass into breast milk, they could potentially harm the neonate. Known potential neonatal side effects of maternal beta-blocker use are hypoglycaemia and bradycardia. This systematic review and meta-analysis aims to investigate the risk for neonatal hypoglycaemia and bradycardia after exposure to beta-blockers in utero or through lactation. Methods and analysis We will conduct a systematic review according to...
Source: BMJ Open - August 25, 2022 Category: General Medicine Authors: de Bruin, R., van Dalen, S. L., Franx, S. J., Simons, S. H., Flint, R. B., van den Bosch, G. E. Tags: Open access, Paediatrics Source Type: research

Effectiveness of {beta}-blockers in physically active patients with hypertension: protocol of a systematic review
The objective of this review is to determine, by comparison of existing mono and combination therapy, which β-blockers are less physically limiting for patients with hypertension who are physically active. Methods A three-step strategy will be adopted in the review, following the methods used by the Joanna Briggs Institute (JBI). The initial search will be conducted using the MEDLINE and EMBASE databases. The second search will involve the listed databases for the published literature (MEDLINE, Biomedica Czechoslovaca, Tripdatabase, Pedro, EMBASE, the Cochrane Central Register of Controlled Trials, Cinahl, WoS) and t...
Source: BMJ Open - June 14, 2016 Category: Journals (General) Authors: Tuckova, D., Klugar, M., Sovova, E., Sovova, M., Stegnerova, L. Tags: Open access, Cardiovascular medicine, Evidence based practice Protocol Source Type: research