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Comparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study
CONCLUSION: Among patients with AF, apixaban use was associated with lower risk for GIB and similar rates of ischemic stroke or systemic embolism, ICH, and all-cause mortality compared with dabigatran, edoxaban, and rivaroxaban. This finding was consistent for patients aged 80 years or older and those with chronic kidney disease, who are often underrepresented in clinical trials.PRIMARY FUNDING SOURCE: None.PMID:36315950 | DOI:10.7326/M22-0511
Source: Annals of Internal Medicine - October 31, 2022 Category: Internal Medicine Authors: Wallis C Y Lau Carmen Olga Torre Kenneth K C Man Henry Morgan Stewart Sarah Seager Mui Van Zandt Christian Reich Jing Li Jack Brewster Gregory Y H Lip Aroon D Hingorani Li Wei Ian C K Wong Source Type: research

Case Series of Thrombosis With Thrombocytopenia Syndrome After COVID-19 Vaccination-United States, December 2020 to August 2021
CONCLUSION: Thrombosis with thrombocytopenia syndrome is a rare but serious adverse event associated with Ad26.COV2.S vaccination. The different demographic characteristics of the 3 cases reported after mRNA-based COVID-19 vaccines and the much lower reporting rate suggest that these cases represent a background rate.PRIMARY FUNDING SOURCE: Centers for Disease Control and Prevention.PMID:35038274 | DOI:10.7326/M21-4502
Source: Annals of Internal Medicine - January 17, 2022 Category: Internal Medicine Authors: Isaac See Allison Lale Paige Marquez Michael B Streiff Allison P Wheeler Naomi K Tepper Emily Jane Woo Karen R Broder Kathryn M Edwards Ruth Gallego Andrew I Geller Kelly A Jackson Shashi Sharma Kawsar R Talaat Emmanuel B Walter Imo J Akpan Thomas L Ortel Source Type: research

Measuring the COVID-19 Mortality Burden in the United States : A Microsimulation Study
CONCLUSION: Beyond excess deaths alone, the COVID-19 pandemic imposed a greater life expectancy burden on persons aged 25 to 64 years, including those with average or above-average life expectancies, and a disproportionate burden on Black and Hispanic communities.PRIMARY FUNDING SOURCE: National Institute on Aging.PMID:34543588 | DOI:10.7326/M21-2239
Source: Annals of Internal Medicine - September 20, 2021 Category: Internal Medicine Authors: Julian Reif Hanke Heun-Johnson Bryan Tysinger Darius Lakdawalla Source Type: research

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