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Therapy: Stem Cell Therapy
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Humanized Mouse Models of Clinical Disease.
Abstract
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized mice have become increasingly important as small, preclinical animal models for the study of human diseases. Since the description of immunodeficient mice bearing mutations in the IL2 receptor common gamma chain (IL2rg(null)) in the early 2000s, investigators have been able to engraft murine recipients with human hematopoietic stem cells that develop into functional human immune systems. These mice can also be engrafted with human tissues such as islets, liver, skin, and most solid and hematologic cancers. Humanized...
Source: Annual Review of Pathology - December 4, 2016 Category: Pathology Authors: Walsh NC, Kenney LL, Jangalwe S, Aryee KE, Greiner DL, Brehm MA, Shultz LD Tags: Annu Rev Pathol Source Type: research
