• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Adalimumab long-term safety: infections, vaccination response and pregnancy outcomes in patients with rheumatoid arthritis
Conclusions This analysis confirms and expands the known safety profile of adalimumab and reports no additional safety risk of laboratory abnormalities, hepatitis B reactivation and pregnancy outcomes, including spontaneous abortions and birth defects. The benefits of influenza vaccination are reinforced. Trial registration numbers NCT00195663, NCT00195702, NCT00448383, NCT00049751, NCT00234845, NCT00650390, NCT00235859, NCT00647920, NCT00649545, NCT00647491, NCT00649922, NCT00538902, NCT00420927, NCT00870467, NCT00650156, NCT00647270, NCT01185288, NCT01185301.
Source: Annals of the Rheumatic Diseases - January 9, 2017 Category: Rheumatology Authors: Burmester, G. R., Landewe, R., Genovese, M. C., Friedman, A. W., Pfeifer, N. D., Varothai, N. A., Lacerda, A. P. Tags: Open access, Immunology (including allergy), Travel medicine, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Anti-TNF treatment blocks the induction of T cell-dependent humoral responses
Conclusions These data indicate that TNF blockade severely impedes the induction of primary TD humoral responses, probably by interfering with the germinal centre reaction.
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Franco Salinas, G., De Rycke, L., Barendregt, B., Paramarta, J. E., Hreggvidstdottir, H., Cantaert, T., van der Burg, M., Tak, P. P., Baeten, D. Tags: Open access, Genetics, Immunology (including allergy), Biological agents, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes Basic and translational research Source Type: research