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DNA polymerase- γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: a potentially protective role for citrus fruit-derived naringenin?
DNA polymerase-γ hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: a potentially protective role for citrus fruit-derived naringenin?
Eur J Pharmacol. 2019 Mar 12;:
Authors: Lutu MR, Nzuza S, Mofo Mato PE, Govender K, Gumede LM, Kumalo SI, Mlambo NN, Hurchund R, Oroma Owira PM
Abstract
Nucleoside reverse transcriptase inhibitors (NRTIs) form the backbone in combination antiretroviral therapy (cARVs). They halt chain elongation of the viral cDNA by acting as false substrates in counterfeit incorporation mechanism to viral RNA-dependent DNA polymerase. In the proc...
Source: European Journal of Pharmacology - March 11, 2019 Category: Drugs & Pharmacology Authors: Lutu MR, Nzuza S, Mofo Mato PE, Govender K, Gumede LM, Kumalo SI, Mlambo NN, Hurchund R, Oroma Owira PM Tags: Eur J Pharmacol Source Type: research
