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Source: Journal of Asthma and Allergy
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Total 685 results found since Jan 2013.
Nasal polyps in patients with asthma: prevalence, impact, and management challenges
Cristobal Langdon,1,2 Joaquim Mullol1–3 1Rhinology Unit and Smell Clinic, Otorhinolaryngology Department, Hospital Clínic, 2Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 3Centre for Biomedical Research in Respiratory Diseases (CIBERES), Barcelona, Catalonia, SpainAbstract: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have coexisting asthma under the concept of “United Airway Disease”, being the combination of both diseases, which is one of the most challenging phenotypes to treat. A...
Source: Journal of Asthma and Allergy - March 13, 2016 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Aspirin-exacerbated respiratory disease: pathophysiological insights and clinical advances
John W Steinke, Jeff M Wilson Asthma and Allergic Disease Center, Carter Immunology Center, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA Abstract: Asthma and chronic rhinosinusitis are heterogeneous airway diseases of the lower and upper airways, respectively. Molecular and cellular studies indicate that these diseases can be categorized into unique endotypes, which have therapeutic implications. One such endotype is aspirin-exacerbated respiratory disease (AERD), which encompasses the triad of asthma, aspirin (or nonsteroidal anti-inflammatory drug) hypersensitivity, and nasal pol...
Source: Journal of Asthma and Allergy - March 9, 2016 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
The asthma–COPD overlap syndrome: how is it defined and what are its clinical implications?
Maarten van den Berge,1,2 René Aalbers,31Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, 2GRIAC Research Institute, University Medical Center Groningen, University of Groningen, 3Department of Pulmonary Diseases, Martini Hospital, Groningen, the Netherlands Abstract: It is increasingly recognized that both asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with a large inter-individual variability with respect to their clinical expression, disease progression, and responsiveness to the available treatments. The introduction of asthma&nda...
Source: Journal of Asthma and Allergy - February 10, 2016 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Predicting frequent asthma exacerbations using blood eosinophil count and other patient data routinely available in clinical practice
Conclusion: Blood eosinophil count and several other variables routinely available in patient records may be used to predict frequent asthma exacerbations. Keywords: exacerbator, risk, multiple, hospitalization
Source: Journal of Asthma and Allergy - January 7, 2016 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review
Megan F Patterson,1 Larry Borish,2,3 Joshua L Kennedy1,4 1Department of Pediatrics, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 2Department of Medicine, Carter Immunology Center, University of Virginia Health Systems, Charlottesville, VA, USA; 3Department of Microbiology, Carter Immunology Center, University of Virginia Health Systems, Charlottesville, VA, USA; 4Department of Internal Medicine, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA Abstract: Asthma is a heterogeneous syndrome that might...
Source: Journal of Asthma and Allergy - November 3, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Profile of anti-IL-5 mAb mepolizumab in the treatment of severe refractory asthma and hypereosinophilic diseases
Francesco Menzella,1 Mirco Lusuardi,2 Carla Galeone,1 Sofia Taddei,1 Luigi Zucchi1 1Department of Cardiac-Thoracic-Vascular and Intensive Care Medicine, Pneumology Unit, Istituto di Ricovero e Cura a Carattere Scientifico- Arcispedale Santa Maria Nuova, Reggio Emilia, Italy; 2Unit of Respiratory Rehabilitation, Azienda Unità Sanitaria Locale Reggio Emilia, S. Sebastiano Hospital, Correggio, Italy Abstract: Asthma is a complex disorder frequently associated with a poor symptom control, concomitant morbidity, mortality, and significant health care costs due to lack of compliance or inadequate therapeutic options. Inte...
Source: Journal of Asthma and Allergy - October 8, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Time for a new language for asthma control: results from REALISE Asia
Conclusion: Patients consistently overestimated their level of asthma control contrary to what their symptoms suggest. They perceived control as management of exacerbations, reflective of a crisis-oriented mind-set. Interventions can leverage on patients' trust in health care providers and desire for self-management via a new language to generate a paradigm shift toward symptom control and preventive care. Keywords: asthma control, attitudes, perception
Source: Journal of Asthma and Allergy - September 23, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Profile of lebrikizumab and its potential in the treatment of asthma
Diego Jose Maselli,1 Holly Keyt,1 Linda Rogers,2 1Department of Medicine, Division of Pulmonary Diseases and Critical Care, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Pulmonary, Critical Care, and Sleep Medicine Division, Mount Sinai-National Jewish Health Respiratory Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAAbstract: Interleukin (IL)-13 has been associated with multiple inflammatory features of asthma. It affects multiple cellular lines in asthma and is a key mediator in airway hyperreactivity and remodeling. Periostin, an extracellular protein, has been us...
Source: Journal of Asthma and Allergy - August 10, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Early childhood wheezers: identifying asthma in later life
Anayansi Lasso-Pirot, Silvia Delgado-Villalta, Adam J Spanier Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA Abstract: Wheeze in young children is common, and asthma is the most common non-communicable disease in children. Prevalence studies of recurrent asthma-like symptoms in children under the age of 5 years have reported that one third of children in the US and Europe are affected, and rates and severity appear to be higher in developing countries. Over the last few decades, significant research efforts have focused on identification of risk factors and predictors of wheeze and ...
Source: Journal of Asthma and Allergy - July 12, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
The impact of parental history on children's risk of asthma: a study based on the National Health and Nutrition Examination Survey-III
Conclusion: Maternal asthma history was strongly associated with the onset of asthma in the second generation, and children whose mother had an earlier age of onset had an increased risk of 3.71. For an approximately 10-year decrease in mother’s age at onset of asthma, the risk of asthma for the offspring increased by 1.37-fold. Using our new risk scores led to smaller standard errors and thus more precise estimates than using a binary indicator. Keywords: parental history, asthma risk, maternal history, survey, family data
Source: Journal of Asthma and Allergy - May 25, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Bronchial thermoplasty in asthma: current perspectives
Balaji Laxmanan, D Kyle Hogarth Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine, Chicago, IL, USA Abstract: Bronchial thermoplasty (BT) is a novel therapy for patients with severe asthma. Using radio frequency thermal energy, it aims to reduce the airway smooth muscle mass. Several clinical trials have demonstrated improvements in asthma-related quality of life and a reduction in the number of exacerbations following treatment with BT. In addition, recent data has demonstrated the long-term safety of the procedure as well as sustained improvements in rates of asthma exacerbations, reduction ...
Source: Journal of Asthma and Allergy - May 15, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Ragweed-induced allergic rhinoconjunctivitis: current and emerging treatment options
Friedrich Ihler, Martin CanisDepartment of Otorhinolaryngology, University Medical Center Göttingen, Göttingen, GermanyAbstract: Ragweed (Ambrosia spp.) is an annually flowering plant whose pollen bears high allergenic potential. Ragweed-induced allergic rhinoconjunctivitis has long been seen as a major immunologic condition in Northern America with high exposure and sensitization rates in the general population. The invasive occurrence of ragweed (A. artemisiifolia) poses an increasing challenge to public health in Europe and Asia as well. Possible explanations for its worldwide spread are climate change and urb...
Source: Journal of Asthma and Allergy - February 15, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Long-acting muscarinic antagonist use in adults with asthma: real-life prescribing and outcomes of add-on therapy with tiotropium bromide
Conclusion: In this real-life asthma population, addition of LAMA therapy was associated with significant decreases in the incidence of exacerbations and antibiotic prescriptions for lower respiratory tract infections in the following year. Keywords: anticholinergic, bronchodilator, exacerbation, asthma control, oral corticosteroids
Source: Journal of Asthma and Allergy - January 14, 2015 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Rituximab therapy in a patient with low grade B-cell lymphoproliferative disease and concomitant acquired angioedema
Ravdeep Kaur, Aerik Anthony Williams, Catherine Baker Swift, Jason W Caldwell Wake Forest University School of Medicine, Wake Forest University, Winston-Salem, NC, USA Abstract: Acquired angioedema is often associated with significant morbidity. An underlying lymphatic malignancy, autoimmune disorder, adenocarcinoma, or other malignancy may be present. Screening for these disorders should occur in all patients with acquired angioedema as treatment may result in resolution of angioedema. Keywords: complement, C1-INH deficiency, ecallantide, hemopathy
Source: Journal of Asthma and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
The effects of concomitant GERD, dyspepsia, and rhinosinusitis on asthma symptoms and FeNO in asthmatic patients taking controller medications
Conclusion: Daytime phlegm and losing the sense of smell suggest that eosinophilic airway inflammation persists, despite anti-inflammatory therapy, in patients with asthma. Although rhinitis and GERD made the subjective symptoms of asthma worse, they did not seem to enhance eosinophilic airway inflammation. Keywords: asthma symptoms, FeNO, rhinosinusitis, GERD, dyspepsia
Source: Journal of Asthma and Allergy - September 5, 2014 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
