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Targeted siRNA delivery using aptamer ‐siRNA chimeras and aptamer‐conjugated nanoparticles
This article is categorized under: Biology ‐Inspired Nanomaterials> Nucleic Acid ‐Based Structures Therapeutic Approaches and Drug Discovery> Nanomedicine for Oncologic Disease
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 2, 2018 Category: Nanotechnology Authors: Padmanaban Sivakumar, Sumin Kim, Han Chang Kang, Min Suk Shim Tags: OVERVIEW Source Type: research

Recent advances of using polyhydroxyalkanoate ‐based nanovehicles as therapeutic delivery carriers
Polyhydroxyalkanoates (PHAs) are a class of diverse biodegradable polyesters that can be produced either by natural bioconversion process or by chemical synthesis via the ring‐opening polymerization of β‐lactones. Because of the excellent biodegradability and biocompatibility, the development of PHA‐based nanovehicles as therapeutic delivery carriers, including nanoparticles, micelles, liposomes, and vesicles, has received considerable attention in recent years, and these sophisticated materials have demonstrated significant impact on the drug bioavailability, better encapsulation, and less toxic properties of biode...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - August 31, 2016 Category: Nanotechnology Authors: Zibiao Li, Xian Jun Loh Tags: Advanced Review Source Type: research

Carbon nanotubes: potential medical applications and safety concerns
This article reviews emerging biomedical applications of CNTs, specifically for therapy. It also deals with challenges associated with possible medical applications of CNTs, such as their not fully understood toxicological profile in the human body. For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors have declared no conflicts of interest for this article.
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - November 27, 2014 Category: Nanotechnology Authors: Valeria Amenta, Karin Aschberger Tags: Advanced Review Source Type: research

Ionic α‐helical polypeptides toward nonviral gene delivery
The advent of polymeric materials has significantly promoted the development and rapid growth of various technologies in biomedical applications, such as tissue engineering and controlled drug and gene delivery. Water‐soluble polypeptides bearing functional side chains and adopting stable secondary structures are a new class of functional polymeric materials of potentially broad applications in medicine and biotechnology. In this article, we summarize our recent effort on the design and synthesis of the water‐soluble α‐helical ionic polypeptides originally developed in our laboratory and highlight their applications...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - November 6, 2014 Category: Nanotechnology Authors: Rujing Zhang, Ziyuan Song, Lichen Yin, Nan Zheng, Haoyu Tang, Hua Lu, Nathan P. Gabrielson, Yao Lin, Kyung Kim, Jianjun Cheng Tags: Advanced Review Source Type: research

Bioengineered nanoparticles for siRNA delivery
Short interfering RNA (siRNA) has been an important laboratory tool in the last two decades and has allowed researchers to better understand the functions of nonprotein‐coding genes through RNA interference (RNAi). Although RNAi holds great promise for this purpose as well as for treatment of many diseases, efforts at using siRNA have been hampered by the difficulty of safely and effectively introducing it into cells of interest, both in vitro and in vivo. To overcome this challenge, many biomaterials and nanoparticles (NPs) have been developed and optimized for siRNA delivery, often taking cues from the DNA delivery fie...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - July 1, 2013 Category: Nanotechnology Authors: Kristen L. Kozielski, Stephany Y. Tzeng, Jordan J. Green Tags: Overview Source Type: research

Polyethylenimines for siRNA and miRNA delivery in vivo
The discovery of RNA interference (RNAi) as a naturally occurring mechanism for gene knockdown has attracted considerable attention toward the use of small interfering RNAs (siRNAs) for therapeutic purposes. Likewise, microRNAs (miRNAs) have emerged as important cellular regulators of gene expression, and their pathological underexpression allows for novel therapeutic strategies (‘miRNA replacement therapy’). To address issues related to the instability, charge, and molecular weight of small RNA molecules, nanoparticle formulations have been explored for their in vivo application. Polyethylenimines (PEIs) are positivel...
Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology - May 1, 2013 Category: Nanotechnology Authors: Sabrina Höbel, Achim Aigner Tags: Advanced Review Source Type: research