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Source: Autophagy
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Total 127 results found since Jan 2013.
ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction
Autophagy. 2022 Feb 28:1-12. doi: 10.1080/15548627.2022.2039993. Online ahead of print.ABSTRACTMacroautophagy/autophagy is a tightly regulated catabolic process, which contributes at baseline level to cellular homeostasis, and upon its stimulation to the adaptive cellular response to intra- and extracellular stress stimuli. Decrease of autophagy activity is occurring upon aging and thought to contribute to age-related-diseases. Recently, we uncovered, upon autophagy induction, the role of de novo DNMT3A (DNA methyltransferase 3 alpha)-mediated DNA methylation on expression of the MAP1LC3 (microtubule associated protein 1 l...
Source: Autophagy - February 28, 2022 Category: Cytology Authors: Patricia Gonz ález-Rodríguez Mathilde Cheray Lily Keane Pinelopi Engskog-Vlachos Bertrand Joseph Source Type: research
The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3
Autophagy. 2022 Mar 1:1-17. doi: 10.1080/15548627.2022.2029671. Online ahead of print.ABSTRACTTFEB (transcription factor EB) and TFE3 (transcription factor binding to IGHM enhancer 3) orchestrate the cellular response to a variety of stressors, including nutrient deprivation, oxidative stress and pathogens. Here we describe a novel interaction of TFEB and TFE3 with the FAcilitates Chromatin Transcription (FACT) complex, a heterodimeric histone chaperone consisting of SSRP1 and SUPT16H that mediates nucleosome disassembly and assembly, thus facilitating transcription. Extracellular stimuli, such as nutrient deprivation or o...
Source: Autophagy - March 1, 2022 Category: Cytology Authors: Eutteum Jeong Jos é A Martina Pablo S Contreras Juhyung Lee Rosa Puertollano Source Type: research
RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction
This study aimed to investigate the role of RTN4/Nogo-A in mediating macroautophagy/autophagy and angiogenesis in the thalamus following middle cerebral artery occlusion (MCAO). We assessed secondary neuronal damage, angiogenesis, vascular autophagy, RTN4 and S1PR2 signaling in the thalamus. The effects of RTN4-S1PR2 on vascular autophagy and angiogenesis were evaluated using lentiviral and pharmacological approaches. The results showed that RTN4 and S1PR2 signaling molecules were upregulated in parallel with angiogenesis in the ipsilateral thalamus after MCAO. Knockdown of Rtn4 by siRNA markedly reduced MAP1LC3B-II conver...
Source: Autophagy - March 9, 2022 Category: Cytology Authors: Peiyi Xiao Jinmin Gu Wei Xu Xingyang Niu Jian Zhang Jingjing Li Yicong Chen Zhong Pei Jinsheng Zeng Shihui Xing Source Type: research
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy
Autophagy. 2022 Nov 7:1-21. doi: 10.1080/15548627.2022.2139921. Online ahead of print.ABSTRACTAlpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts and has developed multiple strategies to counteract the host defense. Here, we demonstrate that the tegument protein UL21 (unique long region 21) in pseudorabies virus (PRV) dampens type I interferon signaling by triggering the degradation of CGAS (cyclic GMP-AMP synthase) through the macroautophagy/autophagy-lysosome pathway. Mechanistically, the UL21 protein scaffolds the E3 ligase UBE3C (ubiquitin protein ligase E3C) to catalyze the K27-l...
Source: Autophagy - November 7, 2022 Category: Cytology Authors: Zicheng Ma Juan Bai Chenlong Jiang Huixin Zhu Depeng Liu Mengjiao Pan Xianwei Wang Jiang Pi Ping Jiang Xing Liu Source Type: research
How cells recognize and remove the perforated lysosome
Autophagy. 2022 Nov 11:1-3. doi: 10.1080/15548627.2022.2138686. Online ahead of print.ABSTRACTMacroautophagy (hereafter autophagy) is a highly conserved intracellular degradation system to maintain cellular homeostasis by degrading cellular components such as misfolded proteins, nonfunctional organelles, pathogens, and cytosol. Conversely, selective autophagy targets and degrades specific cargo, such as organelles, bacteria, etc. We previously reported that damaged lysosomes are autophagy targets, via a process called lysophagy. However, how cells target damaged lysosomes through autophagy is not known. We performed proteo...
Source: Autophagy - November 11, 2022 Category: Cytology Authors: Keisuke Tabata Marika Saeki Tamotsu Yoshimori Maho Hamasaki Source Type: research
The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma
Autophagy. 2022 Nov 30:1-18. doi: 10.1080/15548627.2022.2150003. Online ahead of print.ABSTRACTChemotherapy is an important treatment modality for osteosarcoma (OS), but the development of chemoresistance limits the therapeutic efficacy of OS and results in a poor prognosis. Thus, a better understanding of the mechanisms underlying chemoresistance in OS is essential. We previously demonstrated that COPS3/CSN3 (COP9 signalosome subunit 3) functions as an oncogene to promote OS cells lung metastasis, which is closely related to chemoresistance. Here, we showed that COPS3 was significantly upregulated in OS tissues with poor ...
Source: Autophagy - December 1, 2022 Category: Cytology Authors: Jianfang Niu Taiqiang Yan Wei Guo Wei Wang Tingting Ren Yi Huang Zhiqing Zhao Yiyang Yu Chenglong Chen Qingshan Huang Jingbing Lou Lei Guo Source Type: research
N protein of PEDV plays chess game with host proteins by selective autophagy
In this study, we have found a novel host restriction factor, HNRNPA1, that could inhibit PEDV replication by degrading viral nucleocapsid (N) protein. The restriction factor activates the HNRNPA1-MARCHF8/MARCH8-CALCOCO2/NDP52-autophagosome pathway with the help of transcription factor EGR1 targeting the HNRNPA1 promoter. HNRNPA1 could also promote the expression of IFN to facilitate the host antiviral defense response for antagonizing PEDV infection through RIGI protein interaction. During viral replication, we found that PEDV can, in contrast, degrade the host antiviral proteins HNRNPA1 and others (FUBP3, HNRNPK, PTBP1, ...
Source: Autophagy - March 2, 2023 Category: Cytology Authors: Xueying Zhai Ning Kong Yu Zhang Yiyi Song Wenzhen Qin Xinyu Yang Chenqian Ye Manqing Ye Wu Tong Changlong Liu Hao Zheng Hai Yu Wen Zhang Xia Yang Gaiping Zhang Guangzhi Tong Tongling Shan Source Type: research
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration
This study validates a protective role of Krt8 during overloading-induced IDD and demonstrates that targeting overloading activation of PKNs could be a novel and effective approach to mechano stress-induced pathologies with a wider window of therapeutic opportunity.Abbreviations: AAV: adeno-associated virus; AF: anulus fibrosus; ANOVA: analysis of variance; ATG: autophagy related; BSA: bovine serum albumin; cDNA: complementary deoxyribonucleic acid; CEP: cartilaginous endplates; CHX: cycloheximide; cKO: conditional knockout; Cor: coronal plane; CT: computed tomography; Cy: coccygeal vertebra; D: aspartic acid; DEG: differe...
Source: Autophagy - March 10, 2023 Category: Cytology Authors: Di Wang Qiliang Shang Jianxin Mao Chu Gao Jie Wang Dong Wang Han Wang Haoruo Jia Pandi Peng Mu Du Zhuojing Luo Liu Yang Source Type: research
