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Specialty: Drugs & Pharmacology
Source: European Journal of Pharmacology
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Total 212 results found since Jan 2013.
Inhibiting STAT5 significantly attenuated Ang II-induced cardiac dysfunction and inflammation
Eur J Pharmacol. 2021 Dec 14:174689. doi: 10.1016/j.ejphar.2021.174689. Online ahead of print.ABSTRACTCardiac hypertrophy is a compensatory response to chronic pressure overload. Excessive angiotensin II is an important inducer of cardiac hypertrophy. Signal transducers and activators of transcription 5(STAT5), a member of STATs family which can mediate the transcription of interferon (IFN) genes and immune response has recently been reported to have a close link with non-tumor diseases. However, much remains unknown about how STAT5 might be involved in the progression of hypertrophy. Herein, STAT5-IN-1, a STAT5 inhibitor,...
Source: European Journal of Pharmacology - December 17, 2021 Category: Drugs & Pharmacology Authors: Ge Jin Lintao Wang Jun Ma Source Type: research
Simultaneous nanocarrier-mediated delivery of siRNAs and chemotherapeutic agents in cancer therapy and diagnosis: Recent advances
Eur J Pharmacol. 2021 Dec 14:174639. doi: 10.1016/j.ejphar.2021.174639. Online ahead of print.ABSTRACTRecently, investigations have revealed that RNA interference (RNAi) has a remarkable potential to decrease cancer burden by downregulating genes. Among various RNAi molecules, small interfering RNA (siRNA) has been more attractive for this goal and is able to silence a target pathological path and promote the degradation of a certain mRNA, resulting in either gain or loss of function of proteins. Moreover, therapeutic siRNAs have exhibited low side effects compared to other therapeutic molecular candidates. Nevertheless, s...
Source: European Journal of Pharmacology - December 17, 2021 Category: Drugs & Pharmacology Authors: Negar Bidar Majid Darroudi Ailin Ebrahimzadeh Mohammadreza Safdari Miguel de la Guardia Behzad Baradaran Vahabodin Goodarzi Fatemeh Oroojalian Ahad Mokhtarzadeh Source Type: research
Atractylodin inhibits fructose-induced human podocyte hypermotility via anti-oxidant to down-regulate TRPC6/p-CaMK4 signaling
Eur J Pharmacol. 2021 Nov 12:174616. doi: 10.1016/j.ejphar.2021.174616. Online ahead of print.ABSTRACTHigh fructose has been reported to drive glomerular podocyte oxidative stress and then induce podocyte foot process effacement in vivo, which could be partly regarded as podocyte hypermotility in vitro. Atractylodin possesses anti-oxidative effect. The aim of this study was to explore whether atractylodin prevented against fructose-induced podocyte hypermotility via anti-oxidative property. In fructose-exposed conditionally immortalized human podocytes, we found that atractylodin inhibited podocyte hypermotility, and up-re...
Source: European Journal of Pharmacology - November 15, 2021 Category: Drugs & Pharmacology Authors: Li Chen Ya-Li Tang Zhi-Hong Liu Ying Pan Rui-Qing Jiao Ling-Dong Kong Source Type: research
Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways
CONCLUSION: Flotillin-1 might be used as a molecular marker for GC diagnosis and could be explored as a potential new target for the treatment of GC.PMID:34774850 | DOI:10.1016/j.ejphar.2021.174631
Source: European Journal of Pharmacology - November 14, 2021 Category: Drugs & Pharmacology Authors: Jiahui Wei Ruiqing Wang Yiran Lu Song He Bao Yuan Jiabao Zhang Yu Ding Source Type: research
Stereospecific inhibition of AMPK by (R)-crizotinib induced changes to the morphology and properties of cancer and cancer stem cell-like cells
The objective of the present study was to determine if crizotinib enantiomers could induce changes to the properties of cancer and cancer stem cell (CSC)-like cells at a high concentration (∼ 3 μM). While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo. In vivo administration of (R)-crizotinib inhibited the growth of tumors formed from CSC-like cells by 72%. %. Along with the morphological changes induced by (R)-crizotinib, the expression levels of CD44 (NC...
Source: European Journal of Pharmacology - September 28, 2021 Category: Drugs & Pharmacology Authors: Tae Hyun Kim Jong Hyeok Park Jooyeon Park Dong Min Son Ji-Young Baek Hee Jun Jang Won Ki Jung Youngjoo Byun Sang Kyum Kim Song-Kyu Park Source Type: research
β-elemene blocks lipid-induced inflammatory pathways via PPARβ activation in heart failure
This study aims to investigate the effects of β-elemene on a mouse model of heart failure (HF) and to elucidate the underlying mechanisms in vitro approaches. In this study, left anterior descending (LAD)-induced HF mouse model and oxygen-glucose deprivation/recovery (OGD/R)-induced H9C2 model were leveraged to assess the therapeutic effects of β-elemene. Histological examination, western blot and quantitative real-time PCR analysis (RT-qPCR) and immunofluorescence staining was utilized to elucidate mechanism of β-elemene in lipid-induced inflammation. Results showed that β-elemene improved heart function in HF mice ev...
Source: European Journal of Pharmacology - August 29, 2021 Category: Drugs & Pharmacology Authors: Mingyan Shao Mingmin Wang Lin Ma Qian Wang Pengrong Gao Xue Tian Changxiang Li Linghui Lu Chun Li Wei Wang Yong Wang Source Type: research
Pref-1 induced lung fibroblast differentiation by hypoxia through integrin α5β1/ERK/AP-1 cascade
Eur J Pharmacol. 2021 Jul 28:174385. doi: 10.1016/j.ejphar.2021.174385. Online ahead of print.ABSTRACTChronic obstructive asthma is characterized by airway fibrosis. Hypoxia and connective tissue growth factor (CTGF) play important roles in airway fibrosis. Preadipocyte factor-1 (Pref-1) participates in adipocyte differentiation and liver fibrosis. Herein, we investigated the role of Pref-1 in airway fibrosis in chronic obstructive asthma. We found that Pref-1 was overexpressed in lung tissues from chronic obstructive asthma patients compared to normal subjects. Extracellular matrix proteins were inhibited by Pref-1 small ...
Source: European Journal of Pharmacology - July 31, 2021 Category: Drugs & Pharmacology Authors: Wun-Hao Cheng Kang-Yun Lee Ming-Chih Yu Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research
Allopurinol attenuates oxidative injury in rat hearts suffered ischemia/reperfusion via suppressing the xanthine oxidase/vascular peroxidase 1 pathway
This study aims to explore whether the XO/VPO1 pathway is involved in the anti-oxidative effects of allopurinol on the myocardial I/R injury. In a rat heart model of I/R, allopurinol alleviated I/R oxidative injury accompanied by decreased XO activity, XO-derived products (H2O2 and uric acid), and VPO1 expression (mRNA and protein). In a cardiac cell model of hypoxia/reoxygenation (H/R), allopurinol or XO siRNA reduced H/R injury concomitant with decreased XO activity, VPO1 expression as well as the XO and VPO1-derived products (H2O2, uric acid, and HOCl). Although knockdown of VPO1 could also exert a beneficial effect on ...
Source: European Journal of Pharmacology - July 24, 2021 Category: Drugs & Pharmacology Authors: Yi-Shuai Zhang Li-Qun Lu Ya-Qian Jiang Nian-Sheng Li Xiu-Ju Luo Jin-Wu Peng Jun Peng Source Type: research
Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4
This study revealed that Tβ4 protects hepatocytes by inhibiting the GPX4-mediated ferroptosis pathway, which provides a new strategy and target for the treatment of NAFLD.PMID:34280397 | DOI:10.1016/j.ejphar.2021.174351
Source: European Journal of Pharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Zixin Zhu Ya Zhang Xinhao Huang Li Can Xueke Zhao Yinghui Wang Jing Xue Mingliang Cheng Lili Zhu Source Type: research
