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Specialty: Drugs & Pharmacology
Source: European Journal of Pharmacology
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Total 212 results found since Jan 2013.
Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor < sub > 1/3 < /sub > , Src, and extracellular signal-regulated kinase
Eur J Pharmacol. 2022 Apr 28:174986. doi: 10.1016/j.ejphar.2022.174986. Online ahead of print.ABSTRACTConnexin 43 (Cx43) expression is decreased in the prefrontal cortex of patients with depression, but its significance is still unknown. Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), are involved in the effects of antidepressant. However, the relationship between Cx43 expression and induction of brain-derived neurotrophic factor production by antidepressants is unknown. On the basis of our previous study, which showed that adrenergic receptors stimulation results in potentiation of BDNF expression ...
Source: European Journal of Pharmacology - May 1, 2022 Category: Drugs & Pharmacology Authors: Nozomi Tokunaga Tomoyo Takimoto Yoki Nakamura Kazue Hisaoka-Nakashima Norimitsu Morioka Source Type: research
A transcriptomics and molecular biology based investigation reveals the protective effect and mechanism of carnosol on t-BHP induced HRMECs via Nrf2 signaling pathway
In this study, carnosol was found to inhibit HRMECs injury induced by t-BHP. Transcriptomics and molecular biology illustrated that the mechanism was associated with oxidative stress, vascular system development, apoptosis, cell cycle, cell adhesion, cytoskeleton, and nitric oxide biosynthesis. Carnosol directly scavenged free radicals or activated the Nrf2 signaling pathway to alleviate HRMECs oxidative stress. ML385 pretreatment or Nrf2 small interference RNA (siRNA) inhibited the protective effect of carnosol on HRMECs injury. Moreover, the apoptosis and cell cycle arrest in HRMECs were suppressed by carnosol. Treatment...
Source: European Journal of Pharmacology - April 3, 2022 Category: Drugs & Pharmacology Authors: Yue Ren Yanan Liu Kaiyang Liu Zhan Shu Tianyi Lv Zijun Chen Wenqing Feng Yanling Zhang Source Type: research
Transforming growth factor- β1/Thrombospondin-1/CD47 axis mediates dysfunction in CD34 < sup > + < /sup > cells derived from diabetic older adults
This study tested the hypothesis that transforming growth factor- β1 (TGF-β1) is upregulated in diabetic CD34+ cells and impairs NO generation via thrombospondin-1 (TSP-1)/CD47/NO pathway. CD34+ cells from nondiabetic (ND) (n=58) or diabetic older adults (DB) (both type 1 and type 2) (n=62) were isolated from peripheral blood. TGF-β1 was silenced by using an antisense delivered as phosphorodiamidate morpholino oligomer (PMO-TGF-β1). Migration and proliferation in response to stromal-derived factor-1α (SDF-1α) were evaluated. NO generation and eNOS phosphorylation were determined by flow cytometry. CD34+ cells from ol...
Source: European Journal of Pharmacology - February 26, 2022 Category: Drugs & Pharmacology Authors: Jesmin Jahan Ildamaris Monte de Oca Brian Meissner Shrinidh Joshi Ahmad Maghrabi Julio Quiroz-Olvera Chrisitne Lopez-Yang Stephen H Bartelmez Charles Garcia Yagna P Jarajapu Source Type: research
Sulforaphane regulates the proliferation of leukemia stem-like cells via Sonic Hedgehog signaling pathway
This study explored the effects and related molecular mechanisms of SFN on the proliferation of leukemia stem-like cells in acute myeloid leukemia cells. We found that SFN inhibited the proliferation of leukemia stem-like cells in vitro and in vivo. Meanwhile, we observed that SFN could regulate the stem characteristic of leukemia cells. After SFN treatment, the expression of the key players in the Sonic Hedgehog (Shh) signaling pathway was significantly decreased at the transcriptional and protein levels. To further determine the contribution of the Shh signaling molecular mechanism to SFN-mediated self-renewal capability...
Source: European Journal of Pharmacology - February 14, 2022 Category: Drugs & Pharmacology Authors: Fanping Wang Xiaoyu Huang Yanwei Sun Zhixin Li Ruili Sun Tiesuo Zhao Mingyong Wang Chunxia Yan Peijun Liu Source Type: research
Ursodesoxycholic acid is an FFA4 agonist and reduces hepatic steatosis via FFA4 signaling
This study not only identified a new skeleton of FFA4 agonists, but also demonstrated that FFA4 signal was accounting for the protective effects of UDCA in the NAFLD treatment.PMID:35033554 | DOI:10.1016/j.ejphar.2022.174760
Source: European Journal of Pharmacology - January 16, 2022 Category: Drugs & Pharmacology Authors: Fangfang Xu Jun Wang Pan Wang Tao Hou Han Zhou Yaopeng Zhao Jixia Wang Yanfang Liu Xinmiao Liang Source Type: research
Corrigendum to "siRNA: Mechanism of action, challenges, and therapeutic approaches" Eur. J. Pharmacol. 905 (2021) 174178
Eur J Pharmacol. 2022 Feb 5;916:174741. doi: 10.1016/j.ejphar.2022.174741. Epub 2022 Jan 5.NO ABSTRACTPMID:34998574 | DOI:10.1016/j.ejphar.2022.174741
Source: European Journal of Pharmacology - January 9, 2022 Category: Drugs & Pharmacology Authors: Walhan Alshaer Hadil Zureigat Arwa Al Karaki Abdulfattah Al-Kadash Lobna Gharaibeh Ma'mon M Hatmal Alaa A A Aljabali Abdalla Awidi Source Type: research
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury though the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression
This study aimed to elucidate the roles and possible mechanism of MALAT1 in myocardial IR injury. IR model was established in rats by ligation of the anterior descending artery in vivo, and H9c2 and HL-1 cells were treated by hypoxia/reoxygenation (HR) to construct the model in vitro. The small interfering RNA (siRNA) for MALAT1 and miR-133a-3p mimics, inhibitor was used to transfect the cells. The expression of MALAT1, miR-133a-3p in MIRI were evaluated using real-time quantitative polymerase chain reaction (qRT-PCR)，immunohistochemistry (IHC) and western blot (WB). Relationships between MALAT1, insulin-like growth fact...
Source: European Journal of Pharmacology - December 30, 2021 Category: Drugs & Pharmacology Authors: Xin-Ming Liu Zhenzhou Zhang Jiuchang Zhong Ning Li Tao Wang Lefeng Wang Qian Zhang Source Type: research
