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Specialty: Drugs & Pharmacology
Source: European Journal of Pharmacology
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Total 212 results found since Jan 2013.
Osthole relieves skin damage and inhibits chronic itch through modulation of Akt/ZO-3 pathway in atopic dermatitis
Eur J Pharmacol. 2023 Mar 13:175649. doi: 10.1016/j.ejphar.2023.175649. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is the most prevalent chronic inflammatory skin condition and significantly reduces quality of life. Tight junction (TJ), which is located directly beneath the stratum corneum, maintains skin barrier function and aids in the identification of the cell's "territory". We evaluated seventeen TJ related genes to explore AD related alterations of TJ. Remarkably, we found that the expression of ZO-3, a gene that had not been linked to the development of TJ in AD, was significantly down-regulated in the ski...
Source: European Journal of Pharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Xueqin Hu Yuan Zhou Jianxin Shi Mingxin Qi Xue Li Yan Yang Chan Zhu Changming Wang Zongxiang Tang Yuxiang Ma Guang Yu Source Type: research
Targeting the chemokine ligand 2-chemokine receptor 2 axis provides the possibility of immunotherapy in chronic pain
Eur J Pharmacol. 2023 Mar 10:175646. doi: 10.1016/j.ejphar.2023.175646. Online ahead of print.ABSTRACTChronic pain affects patients' physical and psychological health and quality of life, entailing a tremendous public health challenge. Currently, drugs for chronic pain are usually associated with a large number of side effects and poor efficacy. Chemokines in the neuroimmune interface combine with their receptors to regulate inflammation or mediate neuroinflammation in the peripheral and central nervous system. Targeting chemokines and their receptor-mediated neuroinflammation is an effective means to treat chronic pain. I...
Source: European Journal of Pharmacology - March 12, 2023 Category: Drugs & Pharmacology Authors: Shan Liu Xiao-Bing Lan Miao-Miao Tian Chun-Hao Zhu Lin Ma Jia-Mei Yang Juan Du Ping Zheng Jian-Qiang Yu Ning Liu Source Type: research
COMMD5 is involved in the mechanisms of hypotension after parathyroidectomy in patients receiving hemodialysis
CONCLUSIONS: Serum COMMD5 levels were increased after PTx in SHPT patients. COMMD5 promoted high expression of ANP and eNOS in endothelial cells, leading to vasodilation and resulting in hypotension.PMID:36804542 | DOI:10.1016/j.ejphar.2023.175596
Source: European Journal of Pharmacology - February 22, 2023 Category: Drugs & Pharmacology Authors: Bohou Li Xueqin Chen Juan Hu Guibao Ke Nan Jiang Fengxia Zhang Zhiwen Lian Sichun Wen Qiong Wu Yubin Xia Hong Zhang Sujuan Kuang Lixia Xu Chunyu Deng Shuangxin Liu Source Type: research
Apigenin alleviates oxidative stress-induced myocardial injury by regulating SIRT1 signaling pathway
In conclusion, apigenin protects cardiomyocyte function from oxidative stress-induced myocardial injury by modulating SIRT1 signaling pathway, which provides a new potential therapeutic natural compound for the clinical treatment of cardiovascular diseases.PMID:36781043 | DOI:10.1016/j.ejphar.2023.175584
Source: European Journal of Pharmacology - February 13, 2023 Category: Drugs & Pharmacology Authors: Kun Xu Yao Yang Ming Lan Jiannan Wang Bing Liu Mingjing Yan Hua Wang Wenlin Li Shenghui Sun Kaiyi Zhu Xiyue Zhang Mingyan Hei Xiuqing Huang Lin Dou Weiqing Tang Qing He Jian Li Tao Shen Source Type: research
HM-chromanone reverses the blockade of insulin signaling induced by high glucose levels in human HepG2 cells
This study investigated whether (E)-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone (HM-chromanone) could counteract the high glucose level-induced blockade of insulin signaling in human HepG2 cells. Cells were pre-incubated with glucose (5.5 or 33 mM) and then incubated with a medium containing various concentrations of HM-chromanone. Assays for glucose uptake, glycogen synthesis, and glucose production were performed. Western blotting helped elucidate the underlying molecular mechanisms. High glucose concentration (33 mM) significantly increased p-IRS-1ser307 levels and decreased p-Akt levels. However, HM-chromanon...
Source: European Journal of Pharmacology - November 4, 2022 Category: Drugs & Pharmacology Authors: Jae Eun Park Ji Sook Han Source Type: research
Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway
This study indicates that baicalin is able to attenuate hepatic cell pyroptosis in vivo and in vitro in the case of NASH by regulating the NRF2/HO-1/NRLP3 pathway.PMID:36184988 | DOI:10.1016/j.ejphar.2022.175270
Source: European Journal of Pharmacology - October 3, 2022 Category: Drugs & Pharmacology Authors: Huilian Shi Fei Qiao Weiting Lu Kaiyue Huang Yuanyuan Wen Lifang Ye Yuanyuan Chen Source Type: research
Transcription factor EB protects against endoplasmic reticulum stress in human coronary artery endothelial cells
Eur J Pharmacol. 2022 Sep 12:175274. doi: 10.1016/j.ejphar.2022.175274. Online ahead of print.ABSTRACTOxidative stress and endoplasmic reticulum (ER) stress promote atherogenesis while transcription factor EB (TFEB) inhibits atherosclerosis. Since reducing oxidative stress with antioxidants have failed to reduce atherosclerosis possibly because of aggravation of ER stress, we studied the effect of TFEB on ER stress in human coronary artery endothelial cells. ER stress was measured using the secreted alkaline phosphatase assay. Expression and phosphorylation of key mediators of unfolded protein response (UPR). TFEB, inosito...
Source: European Journal of Pharmacology - September 15, 2022 Category: Drugs & Pharmacology Authors: Michael J Haas Victoria Feng Krista Gonzales Priyanka Bikkina Marie Angelica Landicho Arshag D Mooradian Source Type: research
