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Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP
Nutrition: Fish
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Total 495 results found since Jan 2013.
Life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in antioxidative status, ion regulation and histology of zebrafish gills
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 15:109746. doi: 10.1016/j.cbpc.2023.109746. Online ahead of print.ABSTRACTTris (2-chloroethyl) phosphate (TCEP) has been receiving great concerns owing to its ubiquitous occurrence in various environmental compartments and potential risks to wildlife and humans. Gill is structural basis for ion regulation and homeostasis in fish and susceptible to xenobiotics. However, current knowledge on the impacts of long-term exposure to TCEP on the structure and physiological function of fish gills are insufficient. In this work, zebrafish were exposed to environmental realistic conc...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 17, 2023 Category: Biochemistry Authors: Hangke Peng Hongkai Wang Wen Li Chen Jing Weiwei Zhang Haocheng Zhao Fengxiao Hu Source Type: research
Quercetin attenuates environmental Avermectin-induced ROS accumulation and alleviates gill damage in carp through activation of the Nrf2 pathway
In this study, four groups were created: the Control group, the Que group (400 mg/kg), the AVM group (2.404 μg/L), and the Que plus AVM group. The analytical methods used in this study were pathological structure examination, QPCR, Reactive Oxygen Species (ROS) and Western blot. The results showed that Que alleviated AVM-induced oxidative stress, inflammatory damage and apoptosis in the gill tissues of carp by activating the Nrf2 pathway. The mechanism was that Que alleviated the accumulation of ROS, reduced the balance between oxidation and antioxidant disrupted by AVM exposure, lowered the content of lipid peroxidation ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 13, 2023 Category: Biochemistry Authors: Mengyuan Zhou Jingchao Qiang Jiajie Gan Xuhui Xu Xing Li Shuai Zhang Baoshi Xu Zibo Dong Source Type: research
The effects of P-glycoprotein induction on ivermectin-induced behavioural alterations in zebrafish (Danio rerio) under varying diets
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 7:109740. doi: 10.1016/j.cbpc.2023.109740. Online ahead of print.ABSTRACTThe neuroprotective effects of inducing the blood-brain barrier ATP-binding cassette protein transporter P-glycoprotein (P-gp) with clotrimazole (CTZ) in both fed and fasted zebrafish (Danio rerio) against the CNS-toxicant ivermectin (IVM, 22,23-dihydro avermectin B1a + 22,23-dihydro avermectin B1b) were examined. Zebrafish were administered 2 μmol/kg IVM intraperitoneally, and various behavioural assays (swimming performance, exploratory behaviour, olfactory responses, motor coordination, and escape...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 9, 2023 Category: Biochemistry Authors: Vinicius Cavicchioli Azevedo Christopher J Kennedy Source Type: research
Tricyclic hydrocarbon fluorene attenuates ventricular ionic currents and pressure development in the navaga cod
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Aug 31:109736. doi: 10.1016/j.cbpc.2023.109736. Online ahead of print.ABSTRACTThe release of polycyclic aromatic hydrocarbons (PAHs) into environment due to oil and diesel fuel spills is a serious threat to arctic fish populations. PAHs produce multiple toxic effects in fish, but disturbance of electrical and contractile activity of the heart seems to be the most negative effect. Our study was focused on the effects of fluorene, a tricyclic PAH partially resembling the well-investigated phenanthrene, on major ionic currents and action potential (AP) waveform in isolated ventri...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 2, 2023 Category: Biochemistry Authors: Denis V Abramochkin Tatiana S Filatova Vladislav S Kuzmin Yuri I Voronkov Andre Kamkin Holly A Shiels Source Type: research
Roundup ® disrupts tissue architecture, attenuates Na < sup > + < /sup > /K < sup > + < /sup > -ATPase expression, and induces protein oxidation/nitration, cellular apoptosis, and antioxidant enzyme expressions in the gills of goldfish, Carassius auratus
This study focused on the effects of environmentally relevant concentrations of Roundup exposure (low- and high-dose: 0.5 and 5 μg/L for 2-week) on Na+/K+-ATPase (NKA, a biomarker for sodium‑potassium ion pump efficacy), cytochrome P450-1A (CYP1A, a monooxygenase enzyme), 2,4-dinitrophenyl protein (DNP, a biomarker for protein oxidation), 3-nitrotyrosine protein (NTP, a biomarker for protein nitration), superoxidase dismutase (SOD, an antioxidant enzyme), catalase (CAT, an antioxidant enzyme) expressions, and cellular apoptosis in the gills of goldfish. Histopathological and in situ TUNEL analyses showed widespread tiss...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 2, 2023 Category: Biochemistry Authors: Md Imran Noor Md Saydur Rahman Source Type: research
Dose-dependent stress response of esfenvalerate insecticide on common carp (Cyprinus carpio): Evaluating blood parameters and gene expression
In this study, the aim is to subchronically examine the effects of sublethal concentrations of esfenvalerate insecticide on common carp (Cyprinus carpio) by assessing changes in blood parameters and resulting gene expression. For this purpose, common carp (Cyprinus carpio) were divided into 5 groups and exposed to 0.025, 0.05, 0.1, and 0.15 μg/L concentrations of esfenvalerate for a period of 14 days. Blood and liver tissue samples were collected from the fish that underwent weight and length measurements. The effects on gene expression levels of immune, antioxidant, and stress-related genes in the liver tissue, including...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 2, 2023 Category: Biochemistry Authors: Fahriye Zemheri Navruz Ümit Acar Sevdan Y ılmaz Osman Sabri Kesbi ç Source Type: research
Roundup ® disrupts tissue architecture, attenuates Na < sup > + < /sup > /K < sup > + < /sup > -ATPase expression, and induces protein oxidation/nitration, cellular apoptosis, and antioxidant enzyme expressions in the gills of goldfish, Carassius auratus
This study focused on the effects of environmentally relevant concentrations of Roundup exposure (low- and high-dose: 0.5 and 5 μg/L for 2-week) on Na+/K+-ATPase (NKA, a biomarker for sodium‑potassium ion pump efficacy), cytochrome P450-1A (CYP1A, a monooxygenase enzyme), 2,4-dinitrophenyl protein (DNP, a biomarker for protein oxidation), 3-nitrotyrosine protein (NTP, a biomarker for protein nitration), superoxidase dismutase (SOD, an antioxidant enzyme), catalase (CAT, an antioxidant enzyme) expressions, and cellular apoptosis in the gills of goldfish. Histopathological and in situ TUNEL analyses showed widespread tiss...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 2, 2023 Category: Biochemistry Authors: Md Imran Noor Md Saydur Rahman Source Type: research
