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Novel polyacrylate-based cationic nanoparticles for survivin siRNA delivery combined with mitoxantrone for treatment of breast cancer.
Abstract As a gene delivery method in breast cancer therapy, knocking down the undesired genes in the cancerous cells would be promising. Inhibitors of Apoptosis Protein (IAP) family genes are some of the genes whose responsibility is inhibition of apoptosis in cells. Silencing these genes seems to be helpful directing the tumor cells to death. siRNA sequence designed against survivin anti-apoptotic gene can play this role if carried to the cytoplasm. Here we prepared a positive charged biocompatible nano-sized particle made up of a Fe3O4 core covered respectively by polyacrylate (PA) and polyethyleneimine (PEI) l...
Source: Biologicals : Journal of the International Association of Biological Standardization - October 2, 2016 Category: Biotechnology Authors: Arami S, Mahdavi M, Rashidi MR, Fathi M, Hejazi MS, Samadi N Tags: Biologicals Source Type: research

An adventitious agent-free clonal cell line that is highly susceptible to foot -and-mouth disease virus
In this study, we developed a three-prong methodology to completely remove BVDV from LFBKαVβ6 cells. Combined treatment with siRNA against BVDV NS5A, porcine interferon alpha and ribavirin resulted in the elimination of BVDV, as determined by immunohistochemistry analysis, quantitative RT-PCR and RNA sequencing. Importantly, elimination of BVDV from LFBKαVβ6 did not affect FMDV growth and plaque phenotype from different serotypes isolated and propagated in the clean cell line, newly named MGPK αVβ6-C5. Additionally, isolation of FMDV from field oro-pharyngeal samples, was successful at the same sensitivity as in BVDV...
Source: Biologicals : Journal of the International Association of Biological Standardization - June 7, 2021 Category: Biotechnology Authors: M LaRocco Z Ahmed M Rodriguez-Calzada P A Azzinaro R Barrette P Krug L L Rodriguez T de Los Santos G N Medina Source Type: research