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NAPE-specific phospholipase D regulates LRRK2 association with neuronal membranes
Adv Pharmacol. 2021;90:217-238. doi: 10.1016/bs.apha.2020.09.003. Epub 2020 Oct 6.ABSTRACTN-acylphosphatidylethanolamines (NAPEs) are glycerophospholipid precursors for bioactive lipid amides and potential regulators of membrane function. They are hydrolyzed by NAPE-specific phospholipase D (NAPE-PLD) and have been implicated in neurodegenerative disorders such as Parkinson's disease. Here, we used siRNA-mediated silencing of NAPE-PLD in human SH-SY5Y cells and NAPE-PLD-/- mice to determine whether NAPEs influence the membrane association of LRRK2, a multifunctional protein kinase that is frequently mutated in persons with...
Source: Advances in Pharmacology - March 12, 2021 Category: Drugs & Pharmacology Authors: Francesca Palese Silvia Pontis Natalia Realini Daniele Piomelli Source Type: research

Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.
Abstract Vascular smooth muscle (VSM) plays an important role in maintaining vascular tone. In addition to Ca(2+)-dependent myosin light chain (MLC) phosphorylation, protein kinase C (PKC) is a major regulator of VSM function. PKC is a family of conventional Ca(2+)-dependent α, β, and γ, novel Ca(2+)-independent δ, ɛ, θ, and η, and atypical ξ, and ι/λ isoforms. Inactive PKC is mainly cytosolic, and upon activation it undergoes phosphorylation, maturation, and translocation to the surface membrane, the nucleus, endoplasmic reticulum, and other cell organelles; a process facilitated by scaffold proteins su...
Source: Advances in Pharmacology - February 20, 2017 Category: Drugs & Pharmacology Authors: Ringvold HC, Khalil RA Tags: Adv Pharmacol Source Type: research

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