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Elevation of serum creatine kinase induced by anti-thyroid drugs: Two case reports and a literature review
Int J Clin Pharmacol Ther. 2022 Sep 2. doi: 10.5414/CP204269. Online ahead of print.ABSTRACTAnti-thyroid drugs (ATDs), such as methimazole (MMI) and propylthiouracil (PTU), are the most common treatment options for hyperthyroidism. Although effective, well-known adverse effects include agranulocytosis, toxic hepatitis, vasculitis, and arthralgias. Myalgia and elevation of serum creatine kinase (CK) are relatively rare, with an unclear mechanism. Rapid decrease in the thyroid hormone level may be associated with ATD-related myopathy; however, direct effects of the drug on muscle tissue cannot be excluded. Here we report on ...
Source: Clinical Pharmacology and Therapeutics - September 2, 2022 Category: Drugs & Pharmacology Authors: Yuqi Si Fenli Su Haoxiang Wu Chuangpeng Shen Source Type: research