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Source: Cancer Research
Therapy: Radiation Therapy
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Total 17 results found since Jan 2013.
Abstract 3956: Combination of SPARC and radiation suppresses HSP27 and induces p21(CIP1/WAF1) in neuroblastoma tumor cells
Neuroblastoma (NBL) is the third most common malignancy in children and accounts for more than 15% of cancer-related deaths in children in the US. Approximately 50% of patients present with advanced-stage and/or high risk disease. Despite significant intensification of conventional chemotherapy regimens, the long-term survival rates for these children remain less than 40%. A somewhat improved outcome has been obtained with multimodality therapeutic approaches including chemotherapy, surgery, autologous bone marrow transplantation, radiation therapy and use of biological agents. However, long-term survival rates for childre...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gondi, C. S., Tanpure, S., Antony, R., Fernandez, K. S., Guȷrati, M., Lin, J. Tags: Tumor Biology Source Type: research
Adaptive Response Diminishes Therapeutic Effectiveness
Adaptive responses can be induced in cells by very low doses of ionizing radiation resulting in an enhanced resistance to much larger exposures. The inhibitor of apoptosis protein, survivin, has been implicated in many adaptive responses to cellular stress. Computerized axial tomography used in image-guided radiotherapy to position and monitor tumor response uses very low radiation doses ranging from 0.5 to 100 mGy. We investigated the ability of these very low radiation doses administered along with two 2 Gy doses separated by 24 hours, a standard conventional radiotherapy dosing schedule, to initiate adaptive responses r...
Source: Cancer Research - July 15, 2013 Category: Cancer & Oncology Authors: Grdina, D. J., Murley, J. S., Miller, R. C., Mauceri, H. J., Sutton, H. G., Li, J. J., Woloschak, G. E., Weichselbaum, R. R. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research
