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The α2 isoform Na,K‐ATPase modulates contraction of rat mesenteric small artery via cSrc–dependent Ca2+ sensitization
ConclusionsData suggest that micromolar ouabain potentiates agonist‐induced contraction of rat mesenteric small artery via Na,K‐ATPase dependent cSrc activation, which increases Ca2+ sensitization of vascular smooth muscle cells by MYPT1 phosphorylation. This mechanism may be critical for acute control of vascular tone.
Source: Acta Physiologica - February 26, 2018 Category: Physiology Authors: Elena V. Bouzinova, Lise Hangaard, Christian Staehr, Aleksandra Mazur, Avelino Ferreira, Alexander Chibalin, Shaun L. Sandow, Zijian Xie, Christian Aalkjaer, Vladimir V. Matchkov Tags: Regular Paper Source Type: research

Functional interaction of Junctophilin 2 with small ‐ conductance Ca2+‐activated potassium channel subtype 2(SK2) in mouse cardiac myocytes
ConclusionThe present data provide evidence that the functional interaction between JP2 and SK2 channels is present in the native mouse heart tissue. Junctophilin 2, as junctional membrane complex (JMC) protein, is an important regulator of the cardiac SK channels.
Source: Acta Physiologica - December 7, 2017 Category: Physiology Authors: H. K. Fan, T. X. Luo, W. D. Zhao, Y. H. Mu, Y. Yang, W. J. Guo, H. Y. Tu, Q. Zhang Tags: ORIGINAL ARTICLE Source Type: research

Functional interaction of Junctophilin 2 with small conductance Ca2+ ‐activated potassium channel subtype 2(SK2) in mouse cardiac myocytes
ConclusionsThe present data provide evidence that the functional interaction between JP2 and SK2 channels is present in the native mouse heart tissue. Junctophilin 2, as junctional membrane complex (JMC)protein, is an important regulator of the cardiac SK channels.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - October 21, 2017 Category: Physiology Authors: Hong K. Fan, Tian X. Luo, Wei D. Zhao, Yong H. Mu, Yang Yang, Wen J. Guo, Hui Y. Tu, Qian Zhang Tags: Regular Paper Source Type: research

Metformin promotes irisin release from murine skeletal muscle independently of AMP‐activated protein kinase activation
ConclusionMetformin promotes irisin release from murine skeletal muscle into blood, independently of AMPK pathway activation. Our results suggest that stimulation of irisin may be a novel molecular mechanism of metformin which is widely used for treatment of metabolic disorders.
Source: Acta Physiologica - November 24, 2014 Category: Physiology Authors: D.‐J. Li, F. Huang, W.‐J. Lu, G.‐J. Jiang, Y.‐P. Deng, F.‐M. Shen Tags: Original Article Source Type: research

Metformin promotes irisin release from murine skeletal muscle independently of AMPK activation
ConclusionMetformin promotes irisin release from murine skeletal muscle into blood, independently of AMPK pathway activation. Our results suggest that stimulation of irisin may be a novel molecular mechanism of metformin which is widely used for treatment of metabolic disorders.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - November 11, 2014 Category: Physiology Authors: Dong‐Jie Li, Fang Huang, Wen‐Jie Lu, Guo‐Jun Jiang, Ya‐ping Deng, Fu‐Ming Shen Tags: Regular Paper Source Type: research

Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis
ConclusionActivation of sGC by YC‐1 leads to LXRα‐dependent upregulation of ABCA1 in macrophages and may confer protection against atherosclerosis.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - December 1, 2013 Category: Physiology Authors: Chia‐Yuan Tsou, Chien‐Yu Chen, Jin‐Feng Zhao, Kuo‐Hui Su, Hsueh‐Te Lee, Shing‐Jong Lin, Song‐Kun Shyue, Sheng‐Huang Hsiao, Tzong‐Shyuan Lee Tags: Regular Paper Source Type: research

The homoeobox gene SIX1 alters myosin heavy chain isoform expression in mouse skeletal muscle
ConclusionSix1 knockdown caused a fast‐to‐slow shift in MHC isoform, and this was confirmed by promoter activity of MHC genes. Six1 may ultimately control the contractile and metabolic properties that define muscle fibre phenotype.
Source: Acta Physiologica - November 11, 2013 Category: Physiology Authors: K. L. Hetzler, B. C. Collins, R. A. Shanely, H. Sue, M. C. Kostek Tags: Original Article Source Type: research

The Homeobox Gene Six1 Alters Myosin Heavy Chain Isoform Expression In Mouse Skeletal Muscle
ConclusionSix1 knockdown caused a fast to slow shift in MHC isoform, and this was confirmed by promoter activity of MHC genes. Six1 may ultimately control the contractile and metabolic properties that define muscle fiber phenotype.This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - September 18, 2013 Category: Physiology Authors: Kimbell L. Hetzler, Brittany C. Collins, R. Andrew Shanely, Hannah Sue, Matthew C. Kostek Tags: Regular Paper Source Type: research