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Total 25 results found since Jan 2013.

Hypoxia accelerates vascular repair of endothelial colony-forming cells on ischemic injury via STAT3-BCL3 axis
Conclusions: Hypoxia preconditioning facilitates functional bioactivities of ECFCs by mediating regulation of the STAT3-BCL3 axis. Thus, a hypoxic preconditioned ex vivo expansion protocol triggers expansion and functional bioactivities of ECFCs via modulation of the hypoxia-induced STAT3-BCL3 axis, suggesting that hypo-ECFCs offer a therapeutic strategy for accelerated neovasculogenesis in ischemic diseases.
Source: BioMed Central - July 28, 2015 Category: Journals (General) Authors: Sang LeeJun LeeYong-Seok HanJung RyuYeo YoonHo Han Source Type: research

Interactions between rat alveolar epithelial cells and bone marrow-derived mesenchymal stem cells: an in vitro co-culture model
Conclusions: BMSCs release soluble factors that help maintain and sustain the AEC phenotype for 21 days, and direct interaction between these two cell types can induce a cyst-like, three-dimensional structure covered with AECs.
Source: BioMed Central - May 24, 2015 Category: Journals (General) Authors: Hiroyuki ItoTokujiro UchidaKoshi Makita Source Type: research

Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer
Conclusion: Nectin-4is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer.
Source: BioMed Central - March 28, 2015 Category: Journals (General) Authors: Satoshi NishiwadaMasayuki ShoSatoshi YasudaKeiji ShimadaIchiro YamatoTakahiro AkahoriShoichi KinoshitaMinako NagaiNoboru KonishiYoshiyuki Nakajima Source Type: research

CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis
Conclusions: We demonstrated that C/EBPβ, especially C/EBPβ-LIP in cooperation with ATF4, is involved in osteoclast formation by regulating RANKL expression in RA-FLS. These findings suggest that C/EBPβ plays a crucial role in bone destruction in RA joints.
Source: BioMed Central - February 17, 2015 Category: Journals (General) Authors: Hidetoshi TsushimaKen OkazakiKohei IshiharaTakahiro UshijimaYukihide Iwamoto Source Type: research

Histone deacetylase 6 activity is critical for the metastasis of Burkitt’s lymphoma cells
Conclusions: We identified a critical role of HDAC6 in the metastasis of Burkitt?s lymphoma cells, suggesting that pharmacological inhibition of HDAC6 could be a promising strategy for the management of metastatic Burkitt?s lymphoma.
Source: BioMed Central - December 5, 2014 Category: Journals (General) Authors: Ning DingLingyan PingLixia FengXiaohui ZhengYuqin SongJun Zhu Source Type: research

Silencing of insulin-like growth factor-1 receptor enhances the radiation sensitivity of human esophageal squamous cell carcinoma in vitro and in vivo
Conclusions: The results of the current study suggest that IGF-1r knockdown may enhance the radiation sensitivity of ESCC and increase the therapeutic effects of radiation both in vitro and in vivo. These results provide strong evidence that the targeted application of siRNA will enable the development of new therapeutic strategies for the clinical treatment of ESCC patients.
Source: BioMed Central - November 3, 2014 Category: Journals (General) Authors: Hui ZhaoXiaomeng Gu Source Type: research

The clinical and biological significance of STAT1 in esophageal squamous cell carcinoma
Conclusion: To conclude, our findings suggest that STAT1 is a tumor suppressor in ESCC. Loss of STAT1, which is frequent in ESCC, contributes to the pathogenesis of these tumors.
Source: BioMed Central - October 29, 2014 Category: Journals (General) Authors: Ying ZhangOmmoleila MolaviMin SuRaymond Lai Source Type: research

The role of small RNAs in wide hybridisation and allopolyploidisation between Brassica rapa and Brassica nigra
Conclusions: The study showed that siRNAs and DNA methylation play an important role in maintaining the genome stability in the formation of an allotetraploid. The miRNAs regulate gene expression and induce the phenotype variation, which may play an important role in the occurrence of heterosis in the allotetraploid. The findings of this study may provide new information for elucidating that the allotetraploids have a growth advantage over the parents and the allodiploids.
Source: BioMed Central - October 19, 2014 Category: Journals (General) Authors: Muhammad GhaniJunxing LiLinli RaoMuhammad RazaLiwen CaoNingning YuXiaoxia ZouLiping Chen Source Type: research

The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy
Conclusions: TRIM62 is activated in muscle of critically ill patients. It could play a role in the pathogenesis of ICUAW by activating and maintaining inflammation in myocytes.Trial registrationCurrent Controlled Trials, ISRCTN77569430. Registered 13 February 2008.
Source: BioMed Central - September 29, 2014 Category: Journals (General) Authors: Franziska SchmidtMelanie KnyXiaoxi ZhuTobias WollersheimKathleen PersickeClaudia LanghansDoerte LodkaChristian KleberSteffen Weber-CarstensJens Fielitz Source Type: research

Ubiquitin-proteasome dependent degradation of GABAAalpha1 in autism spectrum disorder
Conclusions: SYVN1 plays a critical role as an E3 ligase in the ubiquitin proteasome system (UPS)-mediated GABAAalpha1 degradation. Thus, inhibition of the ubiquitin-proteasome-mediated GABAAalpha1 degradation may be an important mechanism for preventing GABAAalpha1 turnover to maintain GABAAalpha1 levels and GABA signaling in ASD.
Source: BioMed Central - September 1, 2014 Category: Journals (General) Authors: Amanda CriderChirayu D PandyaDiya PeterAnthony O AhmedAnilkumar Pillai Source Type: research

Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells
Conclusions: The Sendai virosomal delivery system, combined with AFP promoter/enhancer expression machinery, could serve as a generalized mechanism for the expression of genes deleterious to transformed hepatocarcinoma cells. In this system, the epigenetic suppression of c-Myc could have an added advantage for inducing cell death in the targeted cells.
Source: BioMed Central - August 10, 2014 Category: Journals (General) Authors: Mohammad Khalid ZakariaImran KhanPrashant ManiParthaprasad ChattopadhyayDebi P SarkarSubrata Sinha Source Type: research

The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells
Conclusion: RhoC expression might be involved in EMT of ovarian epithelial carcinoma cells, stimulated by TGF-beta1 and VEGF.
Source: BioMed Central - July 1, 2014 Category: Journals (General) Authors: Wen-feng GouYang ZhaoHang LuXue-feng YangYin-ling XiuShuang ZhaoJian-min LiuZhi-tu ZhuHong-zhi SunYun-peng LiuFeng XuYasuo TakanoHua-chuan Zheng Source Type: research

Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK/ NFkappaB signaling pathway in gastric cancer cells
Conclusions: Resistin-induced SDF-1 upregulation by activation of TLR4, p38 MARK and NF-kappaB may explain a new role of resistin in the link of obesity and gastric cancer.
Source: BioMed Central - June 14, 2014 Category: Journals (General) Authors: Yung-Yu HsiehChien-Heng ShenWen-Shih HuangChih-Chien ChinYi-Hung KuoMeng Chiao HsiehHong-Ren YuTe-Sheng ChangTseng-Hsi LinYung-Wei ChiuCheng-Nan ChenHsing-Chun KuoShui-Yi Tung Source Type: research

The expression of the Sprouty 1 protein inversely correlates with growth, proliferation, migration and invasion of ovarian cancer cells
Conclusions: Here, we report the inverse correlation between the expression of Spry1 and growth, proliferation, invasion and migration of ovarian cancer cells.
Source: BioMed Central - June 8, 2014 Category: Journals (General) Authors: Samar Masoumi-MoghaddamAfshin AminiAnahid EhtedaAi-Qun WeiDavid Lawson Morris Source Type: research

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma
Conclusions: Acquisitions of p53 mutations contributed to the resistance of HCC to arsenic trioxide. Nutlin-3 could overcome arsenic trioxide resistance and inhibit tumor metastasis through p73 activation and promoting mutant p53 degradation mediated by arsenic trioxide.
Source: BioMed Central - May 31, 2014 Category: Journals (General) Authors: Tongsen ZhengDalong YinZhaoyang LuJiabei WangYuejin LiXi ChenYingjian LiangXuan SongShuyi QiBoshi SunChangming XieXianzhi MengShangha PanJiaren LiuHongchi JiangLianxin Liu Source Type: research