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Intramuscular versus ultrasound-guided intratenosynovial glucocorticoid injection for tenosynovitis in patients with rheumatoid arthritis: a randomised, double-blind, controlled study
Conclusions In this randomised double-blind clinical trial, patients with RA and tenosynovitis responded significantly better to US-guided intratenosynovial glucocorticoid injection than to intramuscular glucocorticoid injection, both at 4 and 12 weeks follow-up. Trial registration number EudraCT nr: 2013-003486-34.
Source: Annals of the Rheumatic Diseases - March 9, 2017 Category: Rheumatology Authors: Ammitzboll-Danielsen, M., Ostergaard, M., Fana, V., Glinatsi, D., Dohn, U. M., Ornbjerg, L. M., Naredo, E., Terslev, L. Tags: Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Ultrasound findings predict progression to inflammatory arthritis in anti-CCP antibody-positive patients without clinical synovitis
Conclusion Ultrasound features of joint inflammation may be detected in anti-CCP-positive patients without CS. Ultrasound findings predict progression (and rate of progression) to IA, with the risk of progression highest in those with PD signal. Trial registration number NCT02012764; Results.
Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Nam, J. L., Hensor, E. M. A., Hunt, L., Conaghan, P. G., Wakefield, R. J., Emery, P. Tags: Immunology (including allergy), Inflammation, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results from the APPRAISE study
Conclusions In this first international prospective study, the composite PDUS score is responsive to abatacept. GLOESS demonstrated the rapid onset of action of abatacept, regardless of the number of joints examined. Ultrasound is an objective tool to monitor patients with RA under treatment. Trial registration number NCT00767325.
Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: D'Agostino, M.-A., Wakefield, R. J., Berner-Hammer, H., Vittecoq, O., Filippou, G., Balint, P., Möller, I., Iagnocco, A., Naredo, E., Ostergaard, M., Boers, M., Gaillez, C., Van Holder, K., Le Bars, M., on behalf of the OMERACT-EULAR-Ultrasound Ta Tags: Open access, Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Prevalence of ultrasound synovial inflammatory findings in healthy subjects
Conclusions This study describes for the first time, in a large cohort of healthy subjects, the prevalence and location of US signs of joint inflammation and of structural damage in small joints of hands and feet. US abnormalities were quite common, and mostly located in the feet. Further studies are needed to define which US components may allow to discriminate between pathological and physiological findings in the joints commonly affected by inflammatory arthritis conditions.
Source: Annals of the Rheumatic Diseases - September 8, 2016 Category: Rheumatology Authors: Padovano, I., Costantino, F., Breban, M., D'Agostino, M. A. Tags: Immunology (including allergy), Inflammation, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

First step in the development of an ultrasound joint inflammation score for rheumatoid arthritis using a data-driven approach
Conclusions The reduced GSUS and PDUS scores retained most of the information from the total score and performed well in a validation cohort of established RA. Trial registation number NCT01205854, ACTRN12610000284066.
Source: Annals of the Rheumatic Diseases - July 7, 2016 Category: Rheumatology Authors: Aga, A.-B., Hammer, H. B., Olsen, I. C., Uhlig, T., Kvien, T. K., van der Heijde, D., Fremstad, H., Madland, T. M., Lexberg, A. S., Haukeland, H., Rodevand, E., Hoili, C., Stray, H., Bendvold, A. N., Soldal, D. M., Bakland, G., Lie, E., Haavardsholm, E. A Tags: Immunology (including allergy), Inflammation, Radiology, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radio Source Type: research

Targeting ultrasound remission in early rheumatoid arthritis: the results of the TaSER study, a randomised clinical trial
Conclusions In early RA, a MSUS-driven T2T strategy led to more intensive treatment, but was not associated with significantly better clinical or imaging outcomes than a DAS28-driven strategy. Trial registration number NCT00920478.
Source: Annals of the Rheumatic Diseases - May 9, 2016 Category: Rheumatology Authors: Dale, J., Stirling, A., Zhang, R., Purves, D., Foley, J., Sambrook, M., Conaghan, P. G., van der Heijde, D., McConnachie, A., McInnes, I. B., Porter, D. Tags: Immunology (including allergy), Radiology, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnost Source Type: research

Ultrasound-detected inflammation predicts radiographic progression in hand osteoarthritis after 5 years
Conclusions Ultrasound-detected GS synovitis and PD signals were significantly associated with radiographic progression after 5 years. This study supports the use of ultrasound as a tool to detect patients with hand OA who are likely to progress.
Source: Annals of the Rheumatic Diseases - April 6, 2016 Category: Rheumatology Authors: Mathiessen, A., Slatkowsky-Christensen, B., Kvien, T. K., Hammer, H. B., Haugen, I. K. Tags: Immunology (including allergy), Inflammation, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Digital ulcers predict a worse disease course in patients with systemic sclerosis
Conclusions In patients with SSc, HDU at presentation predicts the occurrence of DUs at follow-up and is associated with cardiovascular worsening and decreased survival.
Source: Annals of the Rheumatic Diseases - March 10, 2016 Category: Rheumatology Authors: Mihai, C., Landewe, R., van der Heijde, D., Walker, U. A., Constantin, P. I., Gherghe, A. M., Ionescu, R., Rednic, S., Allanore, Y., Avouac, J., Czirjak, L., Hachulla, E., Riemekasten, G., Cozzi, F., Airo, P., Cutolo, M., Mueller-Ladner, U., Matucci-Cerin Tags: Immunology (including allergy), Radiology, Connective tissue disease, Clinical diagnostic tests, Radiology (diagnostics), Epidemiology Clinical and epidemiological research Source Type: research

Analysis of distribution and severity of inflammation in patients with osteoarthitis compared to rheumatoid arthritis by ICG-enhanced fluorescence optical imaging and musculoskeletal ultrasound: a pilot study
Conclusions US and FOI detected inflammation in both RA and OA highlighting the inflammatory component in the course of OA. The different inflammatory patterns and various shapes of fluorescence enhancement in FOI may offer opportunities to distinguish and determine the inflammatory status in both diseases.
Source: Annals of the Rheumatic Diseases - February 10, 2016 Category: Rheumatology Authors: Glimm, A.-M., Werner, S. G., Burmester, G. R., Backhaus, M., Ohrndorf, S. Tags: Open access, Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and Source Type: research

EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice
To develop evidence based points to consider the use of imaging in the diagnosis and management of juvenile idiopathic arthritis (JIA) in clinical practice. The task force comprised a group of paediatric rheumatologists, rheumatologists experienced in imaging, radiologists, methodologists and patients from nine countries. Eleven questions on imaging in JIA were generated using a process of discussion and consensus. Research evidence was searched systematically for each question using MEDLINE, EMBASE and Cochrane CENTRAL. Imaging modalities included were conventional radiography, ultrasound, MRI, CT, scintigraphy and positr...
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Colebatch-Bourn, A. N., Edwards, C. J., Collado, P., D'Agostino, M.-A., Hemke, R., Jousse-Joulin, S., Maas, M., Martini, A., Naredo, E., Ostergaard, M., Rooney, M., Tzaribachev, N., van Rossum, M. A., Vojinovic, J., Conaghan, P. G., Malattia, C. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Recommendation Source Type: research

Relationship between radiographic joint space narrowing, sonographic cartilage thickness and anatomy in rheumatoid arthritis and control joints
Conclusions Sonographic cartilage assessment in MCPs is closely related to anatomical cartilage thickness. Both JSW and JSN by radiography represent cartilage thickness in the MCP joints of patients with RA quite well. Thus, US is a valid tool for measuring MCT if radiographs are not available or in case of joint malalignment.
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Mandl, P., Supp, G., Baksa, G., Radner, H., Studenic, P., Gyebnar, J., Kurucz, R., Niedermayer, D., Aletaha, D., Balint, P. V., Smolen, J. S. Tags: Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Increased burden of inflammation over time is associated with the extent of atherosclerotic plaques in patients with psoriatic arthritis
Conclusions Exposure to an increased burden of inflammation is associated with more severe atherosclerosis in patients with PsA. This association may be mediated by traditional cardiovascular risk factors.
Source: Annals of the Rheumatic Diseases - September 9, 2015 Category: Rheumatology Authors: Eder, L., Thavaneswaran, A., Chandran, V., Cook, R., Gladman, D. D. Tags: Immunology (including allergy), Obesity (nutrition), Inflammation, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Inflammatory ultrasound features show independent associations with progression of structural damage after over 2 years of follow-up in patients with hand osteoarthritis
Conclusions Inflammatory features, especially when persistently present, are independently associated with radiological progression in HOA after 2.3 years, indicating a role of inflammation in the aetiology of structural damage in HOA.
Source: Annals of the Rheumatic Diseases - August 10, 2015 Category: Rheumatology Authors: Kortekaas, M. C., Kwok, W.-Y., Reijnierse, M., Kloppenburg, M. Tags: Immunology (including allergy), Inflammation, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice
A taskforce comprised of an expert group of 21 rheumatologists, radiologists and methodologists from 11 countries developed evidence-based recommendations on the use of imaging in the clinical management of both axial and peripheral spondyloarthritis (SpA). Twelve key questions on the role of imaging in SpA were generated using a process of discussion and consensus. Imaging modalities included conventional radiography, ultrasound, magnetic resonance imaging, computed tomography (CT), positron emission tomography, single photon emission CT, dual-emission x-ray absorptiometry and scintigraphy. Experts applied research eviden...
Source: Annals of the Rheumatic Diseases - June 10, 2015 Category: Rheumatology Authors: Mandl, P., Navarro-Compan, V., Terslev, L., Aegerter, P., van der Heijde, D., D'Agostino, M. A., Baraliakos, X., Pedersen, S. J., Jurik, A. G., Naredo, E., Schueller-Weidekamm, C., Weber, U., Wick, M. C., Bakker, P. A. C., Filippucci, E., Conaghan, P. G., Tags: Immunology (including allergy), Inflammation, Radiology, Musculoskeletal syndromes, Osteoporosis, Clinical diagnostic tests, Radiology (diagnostics), Calcium and bone Recommendation Source Type: research

Systemic inflammation and cardiovascular risk factors predict rapid progression of atherosclerosis in rheumatoid arthritis
Conclusions Systemic inflammation and CV risk factors were associated with rapid IMT progression. CV risk factors may modify the role of systemic inflammation in determining IMT progression over time. Methotrexate and antitumour necrosis factor agents may influence IMT progression by reducing the effect of the systemic inflammation on the IMT.
Source: Annals of the Rheumatic Diseases - May 8, 2015 Category: Rheumatology Authors: del Rincon, I., Polak, J. F., O'Leary, D. H., Battafarano, D. F., Erikson, J. M., Restrepo, J. F., Molina, E., Escalante, A. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

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