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The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms
Clin Pharmacol Ther. 2022 Feb 12. doi: 10.1002/cpt.2557. Online ahead of print.ABSTRACTStatins reduce cholesterol, prevent cardiovascular disease, and are among the most commonly prescribed medications in the world. Statin-associated musculoskeletal symptoms (SAMS) impact statin adherence and ultimately can impede the long-term effectiveness of statin therapy. There are several identified pharmacogenetic variants that impact statin disposition and adverse events during statin therapy. SLCO1B1 encodes a transporter (SLCO1B1; alternative names include OATP1B1 or OATP-C) that facilitates the hepatic uptake of all statins. ABC...
Source: Clinical Pharmacology and Therapeutics - February 13, 2022 Category: Drugs & Pharmacology Authors: Rhonda M Cooper-DeHoff Mikko Niemi Laura B Ramsey Jasmine A Luzum E Katriina Tarkiainen Robert J Straka Li Gong Sony Tuteja Russell A Wilke Mia Wadelius Eric A Larson Dan M Roden Teri E Klein Sook Wah Yee Ronald M Krauss Richard M Turner Latha Palaniappan Source Type: research

Effect of SLCO1B1 T521C on Statin-related Myotoxicity with Use of Lovastatin and Atorvastatin
Clin Pharmacol Ther. 2021 Jun 11. doi: 10.1002/cpt.2337. Online ahead of print.ABSTRACTThe association between the c.521T>C variant allele in SLCO1B1 (rs4149056) and simvastatin-induced myotoxicity was discovered over a decade ago; however, whether this relationship represents a class effect is still not fully known. The aim of this study was to investigate the relationship between rs4149056 genotype and statin-induced myotoxicity in patients taking atorvastatin and lovastatin. Study participants were from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. A total of 233 statin-induced myopathy +...
Source: Clinical Pharmacology and Therapeutics - June 11, 2021 Category: Drugs & Pharmacology Authors: Brian Lu Laura Sun Manuel Seraydarian Thomas J Hoffmann Marisa W Medina Carlos Iribarren Ronald M Krauss Neil Risch Akinyemi Oni-Orisan Source Type: research