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Therapy: Chemotherapy
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Mitochondria: Inadvertent targets in chemotherapy-induced skeletal muscle toxicity and wasting?
Abstract
Chemotherapy has been associated with increased mitochondrial reactive oxygen species production, mitochondrial dysfunction and skeletal muscle atrophy leading to severe patient clinical complications including skeletal muscle fatigue, insulin resistance and wasting. The exact mechanisms behind this skeletal muscle toxicity are largely unknown, and as such co-therapies to attenuate chemotherapy-induced side effects are lacking. Here, we review the current literature describing the clinical manifestations and molecular origins of chemotherapy-induced myopathy with a focus on the mitochondria as the target ...
Source: Cancer Chemotherapy and Pharmacology - May 10, 2016 Category: Cancer & Oncology Source Type: research
