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Drug: Insulin
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Total 16 results found since Jan 2013.
Combating Resistance to Anti-IGFR Antibody by Targeting the Integrin {beta}3-Src Pathway
Conclusions
Increased Src activation through integrin αβ3 confers considerable resistance against anti–IGF-1R mAb-based therapies in HNSCC and NSCLC cells. Dual targeting of the IGF-1R pathway and collateral integrin β3–Src signaling module may override this resistance.
Source: JNCI - October 15, 2013 Category: Cancer & Oncology Authors: Shin, D. H., Lee, H.-J., Min, H.-Y., Choi, S. P., Lee, M.-S., Lee, J. W., Johnson, F. M., Mehta, K., Lippman, S. M., Glisson, B. S., Lee, H.-Y. Tags: Article Source Type: research
