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Specialty: Chemistry
Drug: Taxotere
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TR4 Promotes Chemoresistance in PCa Stem Cells Gene Regulation
Prostate cancer (PCa) stem/progenitor cells are known to have higher chemoresistance than non-stem/progenitor cells, but the underlying molecular mechanism remains unclear. We found the expression of testicular nuclear receptor 4 (TR4) is significantly higher in PCa CD133+ stem/progenitor cells compared with CD133− non-stem/progenitor cells. Knockdown of TR4 levels in the established PCa stem/progenitor cells and the CD133+ population of the C4-2 PCa cell line with lentiviral TR4 siRNA led to increased drug sensitivity to the two commonly used chemotherapeutic drugs, docetaxel and etoposide, judging from significantly re...
Source: Journal of Biological Chemistry - June 7, 2013 Category: Chemistry Authors: Yang, D.-R., Ding, X.-F., Luo, J., Shan, Y.-X., Wang, R., Lin, S.-J., Li, G., Huang, C.-K., Zhu, J., Chen, Y., Lee, S. O., Chang, C. Tags: Cell Biology Source Type: research
