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Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment
In this important report published in this journal a 55-year-old woman developed symmetrical weakness, and paraesthesias with painful dysthesias of the legs culminating in flaccid paraplegia with absent deep reflexes three days after a second cycle of intravenous oxaliplatin and oral capecitabine. Contemporarily, she developed left ventricular cardiac failure with diminished ejection fraction to 30%. Nerve conduction studies and sensorimotor evoked potentials were compatible with demyelinating polyneuropathy while upper and lower limb electromyography revealed widespread myopathy. The serum creatinine phosphokinase was ext...
Source: Neuromuscular Disorders - April 29, 2013 Category: Neurology Authors: Nicholas G. Kounis, George D. Soufras Tags: Letters to the Editor Source Type: research
