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mTORC2 is an important target for simvastatin-associated toxicity in C2C12 cells and mouse skeletal muscle - Roles of Rap1 geranylgeranylation and mitochondrial dysfunction
In conclusion, mTORC2 inhibition is an important mechanism of simvastatin-induced myotoxicity. Simvastatin inhibits mTORC2 by impairing geranylgeranylation of Rap1 and by inducing mitochondrial dysfunction.PMID:34461118 | DOI:10.1016/j.bcp.2021.114750
Source: Biochemical Pharmacology - August 30, 2021 Category: Drugs & Pharmacology Authors: Gerda M Sanvee Leonie Hitzfeld Jamal Bouitbir Stephan Kr ähenbühl Source Type: research

C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation
In conclusion, myoblasts were more susceptible to the toxic effects of simvastatin and simvastatin impaired myoblast proliferation and myotube formation. Impaired muscle regeneration may represent a new mechanism of statin myotoxicity.PMID:34111424 | DOI:10.1016/j.bcp.2021.114649
Source: Biochemical Pharmacology - June 10, 2021 Category: Drugs & Pharmacology Authors: Gerda M Sanvee Jamal Bouitbir Stephan Kr ähenbühl Source Type: research