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Source: International Journal of Stroke
Condition: Disability
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Total 36 results found since Jan 2013.
The iScore predicts total healthcare costs early after hospitalization for an acute ischemic stroke
ConclusionsThe ischemic Stroke risk score can be useful as a predictor of healthcare utilization and costs early after hospitalization for an acute ischemic stroke.
Source: International Journal of Stroke - October 27, 2015 Category: Neurology Authors: Emmanuel M. Ewara, Wanrudee Isaranuwatchai, Dawn M. Bravata, Linda S. Williams, Jiming Fang, Jeffrey S. Hoch, Gustavo Saposnik, Tags: Research Source Type: research
Specialized stroke rehabilitation services in seven countries
ConclusionThis multinational study of specialized stroke rehabilitation centers shows that a universal definition of specialized rehabilitation is possible, even in quite different countries and settings, in terms of general principles. There were however differences in structures and procedures, which may influence patients' outcomes, indicating a need for refinement of the definitions to be globally applicable.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Birgitta Langhammer, Frank Becker, Katharina Stibrant‐Sunnerhagen, Tang Zhong, Xiaoxia Du, Tamara Bushnik, Maria Panchenko, Ofer Keren, Samir Banura, Khamis Elessi, Fuad Luzon, Åsa Lundgren‐Nilsson, Xie Li, Susanne Sällström, Johan Kvalvik Stanghel Tags: Research Source Type: research
Safety and efficacy of intensive vs. guideline antiplatelet therapy in high‐risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388)
DiscussionThe trial has recruited more than 50% of its target sample size (latest number: 2399) and is running in 104 sites in 4 countries. One‐third of patients presented with a transient ischemic attack.
Source: International Journal of Stroke - June 16, 2015 Category: Neurology Tags: Protocol Source Type: research
Cognitive performance following lacunar stroke in Spanish‐speaking patients: results from the SPS3 trial
ConclusionsMild cognitive impairment in Secondary Prevention of Small Subcortical Strokes Spanish‐speaking patients with recent lacunar stroke is highly prevalent but has a different pattern to that observed in English‐speaking patients. A combination of socio‐demographics, stroke biology, and stroke care may account for these differences.
Source: International Journal of Stroke - May 14, 2015 Category: Neurology Authors: Claudia Jacova, Lesly A. Pearce, Ana M. Roldan, Antonio Arauz, Jorge Tapia, Raymond Costello, Leslie A. McClure, Robert G. Hart, Oscar R. Benavente Tags: Research Source Type: research
Burden of stroke in Italy: An economic model highlights savings arising from reduced disability following thrombolysis
ConclusionOur study reveals that performing thrombolytic therapy in eligible patients improves economic outcomes compared with patients receiving standard care. This model is useful for decision makers, both within and outside of the Italian national context, as a tool to assess the cost‐effectiveness of thrombolysis in both short‐ and long‐term period.
Source: International Journal of Stroke - April 8, 2015 Category: Neurology Authors: M. Chiumente, M. M. Gianino, D. Minniti, T. J. Mattei, B. Spass, K. M. Kamal, D. E. Zimmerman, A. Muca, E. Luda Tags: Research Source Type: research
Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy (ENCHANTED) trial: An international multicenter 2 × 2 quasi‐factorial randomized controlled trial of low‐ vs. standard‐dose rt‐PA and early intensive vs. guideline‐recommended blood pressure lowering in patients with acute ischaemic stroke eligible for thrombolysis treatment
ConclusionsLow‐dose iv rt‐PA and early intensive BP lowering could provide more affordable and safer use of thrombolysis treatment for patients with AIS worldwide.
Source: International Journal of Stroke - April 2, 2015 Category: Neurology Authors: Yining Huang, Vijay K. Sharma, Thompson Robinson, Richard I. Lindley, Xiaoying Chen, Jong Sung Kim, Pablo Lavados, Verónica Olavarría, Hisatomi Arima, Sully Fuentes, Huy Thang Nguyen, Tsong‐Hai Lee, Mark W. Parsons, Christopher Levi, Andrew M. Demchuk Tags: Protocol Source Type: research
ICARUSS, the Integrated Care for the Reduction of Secondary Stroke trial: rationale and design of a randomized controlled trial of a multimodal intervention to prevent recurrent stroke in patients with a recent cerebrovascular event, ACTRN = 12611000264987
ConclusionThe ICARUSS study aims to recruit and follow up patients between 2007 and 2013 and demonstrate the effectiveness of exposure to the ICARUSS model in stroke survivors to reduce recurrent stroke or vascular events and promote the implementation of best practice risk factor management at primary care level.
Source: International Journal of Stroke - April 1, 2015 Category: Neurology Authors: J. Joubert, S. M. Davis, G. J. Hankey, C. Levi, J. Olver, G. Gonzales, G. A. Donnan Tags: Protocol Source Type: research
Solitaire™ with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) trial: protocol for a randomized, controlled, multicenter study comparing the Solitaire revascularization device with IV tPA with IV tPA alone in acute ischemic stroke
RationaleEarly reperfusion in patients experiencing acute ischemic stroke is critical, especially for patients with large vessel occlusion who have poor prognosis without revascularization. Solitaire™ stent retriever devices have been shown to immediately restore vascular perfusion safely, rapidly, and effectively in acute ischemic stroke patients with large vessel occlusions.
AimThe aim of the study was to demonstrate that, among patients with large vessel, anterior circulation occlusion who have received intravenous tissue plasminogen activator, treatment with Solitaire revascularization devices reduces degree of disab...
Source: International Journal of Stroke - March 16, 2015 Category: Neurology Authors: Jeffrey L. Saver, Mayank Goyal, Alain Bonafe, Hans‐Christoph Diener, Elad I. Levy, Vitor M. Pereira, Gregory W. Albers, Christophe Cognard, David J. Cohen, Werner Hacke, Olav Jansen, Tudor G. Jovin, Heinrich P. Mattle, Raul G. Nogueira, Adnan H. Siddiqu Tags: Protocols Source Type: research
FAmily‐Led RehabiliTaTion aftEr Stroke in INDia: the ATTEND pilot study
ConclusionThe pilot study established the feasibility of conducting a large‐scale study of family‐led, trained caregiver‐delivered, home‐based stroke rehabilitation in a low resource setting. The main phase of the trial ‘ATTEND’ is currently underway in over 10 centers in India.
Source: International Journal of Stroke - March 1, 2015 Category: Neurology Authors: Jeyaraj D. Pandian, Cynthia Felix, Paramdeep Kaur, Deepika Sharma, Lizzie Julia, Gagan Toor, Rajni Arora, Dorcas B.C. Gandhi, Shweta J. Verma, Craig S. Anderson, Peter Langhorne, G.V.S. Murthy, Maree L. Hackett, Pallab K. Maulik, Mohammed Alim, Lisa A. Ha Tags: Research Source Type: research
Stroke incidence and case‐fatality among Indigenous and non‐Indigenous populations in the Northern Territory of Australia, 1999–2011
ConclusionsIn the Northern Territory, as elsewhere in Australia, Indigenous Australians are more likely than other Australians to suffer a stroke. Lack of falling in incidence in the Northern Territory population highlights the importance for ongoing comprehensive primary and acute care in reducing risk factors and managing stroke patients.
Source: International Journal of Stroke - January 15, 2015 Category: Neurology Authors: Jiqiong You, John R. Condon, Yuejen Zhao, Steven L. Guthridge Tags: Research Source Type: research
Circadian sleep/wake rhythm abnormalities as a risk factor of a poststroke apathy
ConclusionThese results indicate that early poststroke alterations of sleep/wake circadian rhythms – easily evaluated by actigraphy – are associated with a higher risk of poststroke apathy at three‐months. In terms of clinical outcomes, our results provide targets for very early identification of patients at risk to develop apathy after stroke and for assessing when to start specific therapy to optimize rehabilitation efficiency.
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Charlotte Cosin, Igor Sibon, Mathilde Poli, Michèle Allard, Sabrina Debruxelles, Pauline Renou, François Rouanet, Willy Mayo Tags: Research Source Type: research
Should minor stroke patients be thrombolyzed? A focused review and future directions
Stroke is a leading cause of morbidity and mortality worldwide. Up to 80% of ischemic stroke patients may initially present with minor symptoms. Minor stroke and transient ischemic attack patients are typically treated conservatively with antiplatelet agents and general vascular prevention strategies. Yet a high proportion develop recurrent stroke or progression of stroke and up to one in four of these patients are disabled or dead at follow‐up. Minor or rapidly improving symptoms are the top reasons for withholding thrombolytic therapy to time‐eligible stroke patients as they are believed to be ‘too good to treat’...
Source: International Journal of Stroke - December 25, 2014 Category: Neurology Authors: Amy Y. X. Yu, Michael D. Hill, Shelagh B. Coutts Tags: Review (invited) Source Type: research
Protective effect of grape seed and skin extract on cerebral ischemia in rat: implication of transition metals
Ischemic stroke is a leading cause of long lasting disability in humans and oxidative stress an important underlying cause. The present study aims to determine the effect of short term (seven‐days) administration of high dosage grape seed and skin extract (GSSE 2·5 g/kg) on ischemia/reperfusion (I/R) injury in a rat model of global ischemia. Ischemia was induced by occlusion of the common carotid arteries for 30 min followed by one‐hour reperfusion on control or GSSE treated animals. I/R induced a drastic oxidative stress characterized by high lipid and protein oxidation, a drop in antioxidant enzyme defenses, dis...
Source: International Journal of Stroke - November 3, 2014 Category: Neurology Authors: Kadri Safwen, Smine Selima, Elayed Mohamed, Limam Ferid, Cosette Pascal, Amri Mohamed, Aouani Ezzedine, Mokni Meherzia Tags: Research Source Type: research
World Stroke Organization Global Stroke Services Guidelines and Action Plan
Every two seconds, someone across the globe suffers a symptomatic stroke. ‘Silent’ cerebrovascular disease insidiously contributes to worldwide disability by causing cognitive impairment in the elderly. The risk of cerebrovascular disease is disproportionately higher in low to middle income countries where there may be barriers to stroke care. The last two decades have seen a major transformation in the stroke field with the emergence of evidence‐based approaches to stroke prevention, acute stroke management, and stroke recovery. The current challenge lies in implementing these interventions, particularly in regions ...
Source: International Journal of Stroke - September 23, 2014 Category: Neurology Authors: Patrice Lindsay, Karen L. Furie, Stephen M. Davis, Geoffrey A. Donnan, Bo Norrving Tags: Guidelines Source Type: research
Part II: predictors of depression after stroke and impact of depression on stroke outcome: an updated systematic review of observational studies
ConclusionsEarly identification of patients at high risk of depression after stroke, those with a history of depression and physical disability after stroke, would enable the early implementation of effective management and prevention strategies for depression. The reciprocal relationship between depression and physical disability highlights the need for interventions that reduce disability after stroke, which may in turn improve mood and overall recovery for an increasingly large number of stroke survivors.
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: Mansur A. Kutlubaev, Maree L. Hackett Tags: Research Source Type: research
