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OnabotulinumtoxinA in Lower Limb Spasticity: Safety Results from a Pooled Analysis (P03.266)
CONCLUSIONS: OnabotulinumtoxinA treatment in lower limb spasticity was found to be safe and well-tolerated. Majority of AEs were considered not related to onabotulinumtoxinA and treatment-related AEs are consistent with the known mechanism of action of onabotulinumtoxinA.Supported by: Allergan, Inc.Disclosure: Dr. Earl has received personal compensation for activities with Allergan, Inc. as an employee. Dr. Earl holds stock and/or stock options in AGN and GlaxoSmithKline, Inc. Dr. James has received personal compensation for activities with Allergan, Inc as an employee. Dr. Li has received personal compensation for activit...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Earl, N., James, L., Li, H.-I., Shi, G., Demos, G., Dimitrova, R. Tags: P03 Neural Repair Source Type: research

Defining the Border-Zone between Episodic Migraine (EM) and Chronic Migraine (CM): Medical Comorbidities in the US Population (P03.110)
CONCLUSIONS: The comorbidity profiles of HFEM have much more in common with CM than with LFEM suggesting that HFEM and CM may bear a close biological relationship.Supported by: The American Migraine Prevalence and Prevention Study is funded through a research grant to the National Headache Foundation from Ortho-McNeil Neurologics, Inc., Titusville, NJ. Additional analyses were supported by a grant from Allergan Inc., Irvine, CA, to the National Headache Foundation. Abstract development was conducted independent of financial support.Disclosure: Dr. Serrano has received research support from Allergan, ENDO Pharmaceuticals, M...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Serrano, D., Buse, D., Reed, M., Pavlovic, J., Vollbracht, S., Sollars, C. M., Lipton, R. Tags: P03 Headache: Epidemiology Source Type: research

Neuropathological Correlates of Visual Hallucinations in Parkinsonism (S03.006)
CONCLUSIONS: These findings suggest that Lewy-related pathology is specifically implicated in the genesis of VH in PD and related disorders. Plaque and tangles, although present in many cases, did not contribute to the occurrence of VH.Supported by: The Brain Donation Program is supported by the National Institute of Neurological Disorders and Stroke (U24 NS072026 National Brain and Tissue Resource for Parkinson's Disease and Related Disorders), the National Institute on Aging (P30 AG019610 Arizona Alzheimer's Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer's Research Cen...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Morshed, T., Jacobson, S., Beach, T., Adler, C., Shill, H., Caviness, J., Belden, C., Sue, L., Sabbagh, M., Hu, C., Davis, K. Tags: S03 Parkinson ' s Disease Source Type: research

Classifying Patients with Spatial Neglect by "Aiming" Versus "Where" Spatial Bias May Explain Differential Response to Bromocriptine Treatment (P03.261)
CONCLUSIONS: Classifying spatial neglect may be vital to interpreting rehabilitation outcomes and treatment studies. In this group study, larger than those performed previously, patients with "aiming" bias appeared to respond favorably to bromocriptine. However, "aiming" neglect patients may also have had milder neglect than those with "where" bias. Therefore, identifying "aiming" bias may also identify milder forms of neglect likely to respond to bromocriptine. Future studies with more bias-characterized patients are indicated.Disclosure: Dr. Chaudhari has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Goedert...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Chaudhari, A., Shah, P., Goedert, K., Adler, U., Barrett, A. Tags: P03 Neural Repair Source Type: research

OnabotulinumtoxinA Efficacy in Lower Limb Spasticity: Results of Three Studies (P03.264)
CONCLUSIONS: OnabotulinumtoxinA (300U) significantly decreases ankle flexor tone in adults with post-stroke lower-limb spasticity.Supported by: Allergan, Inc.Disclosure: Dr. Dimitrova has received personal compensation for activities with Allergan, Inc. as an employee. Consulting service from Glaxo-Smith-Kline, Japan.....Financial support from GSK Japan, Eisai Dr. Kaji has received personal compensatino for activities with Glaxo-Smith-Kline, Japan as a consultant. Dr. Kaji has received research support from GSK Japan, Eisai. Dr. Ward has received personal compensation for activities with Allergan Inc. as a participant on a...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Dimitrova, R., Kaji, R., Ward, A., Li, H.-I., Fulford-Smith, A., Earl, N. Tags: P03 Neural Repair Source Type: research

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