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Distribution of risk factors differs from coronary heart disease and stroke in China: a national population survey
Conclusions The distribution of risk factors for CHD and stroke were substantial differences. More specific prevention and control measures should be formulated according to the distribution differences of risk factors related to CVD.
Source: BMJ Open - November 24, 2022 Category: General Medicine Authors: Li, Y., Yin, L., Shen, Y., Wang, A., Zhou, L., Gao, Y., Li, Y., Lu, J., Shi, S., Tian, C., Xu, Y., Wang, L., on behalf of the China National Stroke Screening Survey investigators Tags: Open access, Public health Source Type: research

Stroke incidence and association with risk factors in women: a 32-year follow-up of the Prospective Population Study of Women in Gothenburg
Conclusions Hypertension, smoking, AF, diabetes and high BMI were associated with increased stroke risk. Low education was associated with stroke. Validation of National Patient Registry diagnoses to increase specified diagnoses improved data quality.
Source: BMJ Open - October 28, 2014 Category: Journals (General) Authors: Blomstrand, A., Blomstrand, C., Ariai, N., Bengtsson, C., Bjorkelund, C. Tags: Open access, Cardiovascular medicine, Epidemiology Research Source Type: research

Stroke prevention of thoracoscopic left atrial appendage clipping in patients with non-valvular atrial fibrillation at high risk of stroke and bleeding: study protocol for a non-randomised controlled clinical trial
Introduction Non-valvular atrial fibrillation (NVAF) is a high-risk factor for ischaemic stroke. The 2016 European Society of Cardiology Atrial Fibrillation Management guidelines recommend oral anticoagulants (OACs) to prevent stroke in men with CHA2DS2-VASc scores ≥2 and women ≥3. However, in patients with a high risk of stroke and a high risk of bleeding (HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (> 65 years), Drugs/alcohol concomitantly) score≥3), OAC had a higher risk of bleeding. Left atrial appendage cl...
Source: BMJ Open - October 28, 2022 Category: General Medicine Authors: Ye, C., Han, X., Chen, Y., Liu, F., Ma, H., Yang, Y., Liu, Y., Hu, Q., Yao, Q., Xie, W., Xu, D. Tags: Open access, Surgery Source Type: research

Clinical characteristics, precipitating factors, management and outcome of patients with prior stroke hospitalised with heart failure: an observational report from the Middle East
Conclusions This observational study reports high prevalence of prior stroke in patients hospitalised with HF. Internists rather than cardiologists were the predominant caregivers in this high-risk group. Patients with stroke had higher risk of in-hospital recurrent strokes and long-term mortality rates. Trial registration number NCT01467973.
Source: BMJ Open - April 23, 2015 Category: Journals (General) Authors: Khafaji, H. A. R., Sulaiman, K., Singh, R., AlHabib, K. F., Asaad, N., Alsheikh-Ali, A., Al-Jarallah, M., Bulbanat, B., AlMahmeed, W., Ridha, M., Bazargani, N., Amin, H., Al-Motarreb, A., AlFaleh, H., Elasfar, A., Panduranga, P., Al Suwaidi, J. Tags: Open access, Cardiovascular medicine Research Source Type: research

Major cardiovascular events in patients presenting with acute stroke: a 5-year follow-up study in patients who had ischaemic stroke and stroke mimics
Conclusions Prior CVD significantly increases the risk of MACE and early mortality in IS or SM patients. Age, male gender, obesity, atrial fibrillation and admission National Institute of Health Stroke Scale also increases risk of MACE during follow-up. Hence, aggressive vascular risk factor modification is needed even in patients with SM.
Source: BMJ Open - March 2, 2022 Category: General Medicine Authors: Al Jerdi, S., Akhtar, N., Mahfoud, Z., Kamran, S., Shuaib, A. Tags: Open access, Neurology Source Type: research

Predictors for the prognosis and recurrence of ischaemic stroke among young Chinese patients: a cohort study
Conclusions Our research shows that when developing prevention strategies for young people, measures that focus on mitigating risk factors should be considered. In addition, vascular screening of young populations is also of vital importance for stroke prevention and poor prognosis prediction.
Source: BMJ Open - May 2, 2022 Category: General Medicine Authors: Wang, L., Ge, J., Chen, Y., Liu, Y., Li, C., Dong, Y., Liu, L., Xing, Y. Tags: Open access, Neurology Source Type: research

Protocol for Home-Based Solution for Remote Atrial Fibrillation Screening to Prevent Recurrence Stroke (HUA-TUO AF Trial): a randomised controlled trial
The objective of the study was to explore the use of long-term home-based ECG monitoring for AF detection and stroke prevention in patients with a history of stroke. Methods and analysis This prospective, randomised, open-label trial with blinded endpoint adjudication aimed to evaluate the efficacy of long-term home-based ECG monitoring for AF detection and stroke prevention in a 24-month period. Patients aged >18 years with a history of ischaemic stroke will be stratified according to the time from the index ischaemic stroke: <1, 1–3 and >3 years and then randomised in 1:1 to (1) home-based AF screening an...
Source: BMJ Open - July 15, 2022 Category: General Medicine Authors: Wong, C. K., Hai, J. J., Lau, Y.-M., Zhou, M., LUI, H.-W., Lau, K. K., Chan, K.-H., Mok, T. M., Liu, Y., Feng, Y., Tan, N., Tam, W.-C., Tam, K.-C., Feng, X., Zuo, M.-L., Yin, L.-X., Tan, J., Zhang, W.-J., Jiang, X., Huang, X., Ye, J., Liang, Y., Jiang, W. Tags: Open access, Cardiovascular medicine Source Type: research

Neurology care and the long-term outcomes of atrial fibrillation-related ischaemic stroke in China: median 3-year outcome from a high volume academic tertiary hospital
Conclusions Secondary stroke prevention in AF patients associated with neurology care is challenging in China, as manifested by a lower AF detection rate, significant underuse of OACs, high mortality and recurrent stroke rate. Efforts to increasing the AF detection rate and reinforce education on neurologists should be made to improve neurology care and intensify posthospital management in such patients.
Source: BMJ Open - February 2, 2023 Category: General Medicine Authors: Wang, Z., Wu, N., Wu, F., Zhang, L., Gao, X., Yang, Y., Li, M., Wan, Q., Chen, M. Tags: Open access, Health policy Source Type: research

Retrospective case review of missed opportunities for primary prevention of stroke and TIA in primary care: protocol paper
This study will investigate: (1) the proportion of strokes/TIAs with prior missed opportunities for prevention in primary care; (2) the influence of patient characteristics on missed prevention opportunities and (3) how the proportion of missed prevention opportunities has changed over time. Methods and analysis A retrospective case review will identify first-ever stroke and patients with TIA between 2000 and 2013 using anonymised electronic medical records extracted from the health improvement network (THIN) database. Four categories of missed opportunities for stroke/TIA prevention will be sought: untreated high blood p...
Source: BMJ Open - November 11, 2014 Category: Journals (General) Authors: Moran, G. M., Calvert, M., Feltham, M. G., Marshall, T. Tags: Open access, Cardiovascular medicine, Epidemiology, General practice / Family practice, Global health Protocol Source Type: research

Atrial cardiomyopathy in patients with ischaemic stroke: a cross-sectional and prospective cohort study--the COAST study
This study uses cardiac magnetic resonance (CMR) to evaluate atrial cardiomyopathy among patients with stroke of undetermined aetiology compared with those with an attributable mechanism and controls without established cardiovascular disease. Methods and analysis This cross-sectional and prospective cohort study included 100 patients with recent ischaemic stroke and 50 controls with no established cardiovascular disease. The study will assess LA structural and functional abnormalities with CMR. Inclusion began in March 2019, and follow-up is planned to be complete in January 2023. There are two scheduled follow-ups: (1) ...
Source: BMJ Open - May 11, 2022 Category: General Medicine Authors: Larsen, B. S., Aplin, M., Host, N., Dominguez, H., Christensen, H., Christensen, L. M., Havsteen, I., Prescott, E., Jensen, G. B., Vejlstrup, N., Bertelsen, L., Sajadieh, A. Tags: Open access, Cardiovascular medicine Source Type: research

Assessment of mental health trajectories before and after myocardial infarction, atrial fibrillation or stroke: analysis of a cohort study in Tromso, Norway (Tromso Study, 1994-2016)
Conclusion The study indicates that mental health problems among individuals with myocardial infarction, atrial fibrillation and stroke may have started to develop several years before the cardiovascular event and suggests that successful CVD rehabilitation may need to consider previous life factors. Future research is recommended to examine whether health promotion measures in a general population also create mental health resilience after a CVD event.
Source: BMJ Open - April 1, 2022 Category: General Medicine Authors: Lorem, G. F., Opdal, I. M., Wilsgaard, T., Schirmer, H., Lochen, M.-L., Olsen, I. P., Steigen, T., Rognmo, K. Tags: Open access, Mental health Source Type: research

Electrophysiological ventricular substrate of stroke: a prospective cohort study in the Atherosclerosis Risk in Communities (ARIC) study
Conclusions PVC burden (reflected by cardiac memory) is associated with ischaemic stroke. Transient cardiac memory (likely through TD-IBBB) precedes ICH.
Source: BMJ Open - September 3, 2021 Category: General Medicine Authors: Johnson, J. A., Haq, K. T., Lutz, K. J., Peters, K. K., Paternostro, K. A., Craig, N. E., Stencel, N. W. L., Hawkinson, L. F., Khayyat-Kholghi, M., Tereshchenko, L. G. Tags: Open access, Cardiovascular medicine Source Type: research

Phenotypes of atrial fibrillation diagnosed before-versus-after ischaemic stroke and TIA: study protocol for a systematic review and meta-analysis
This study will be based on published data and does therefore not require ethical clearance. The results will be published in peer-reviewed journals. PROSPERO registration number CRD42020202622.
Source: BMJ Open - July 2, 2021 Category: General Medicine Authors: Jimenez-Ruiz, A., Vargas-Gonzalez, J. C., Fridman, S., Sposato, L. A. Tags: Open access, Neurology Source Type: research

Incidence of stroke, systemic embolism and bleeding events in patients without anticoagulation based on real-world data in Japan: a retrospective cohort study
Conclusions Approximately one-third of the patients do not receive any anticoagulation in the modern DOAC era in Japan. The SSE rate increases by the CHADS2 score. The SSE rate is low in patients with a CHADS2 score <1, supporting no indication of anticoagulation in current guidelines. In patients with a CHADS2 score >1, the use of anticoagulant drug therapy is recommended because of a higher risk of stroke.
Source: BMJ Open - November 10, 2022 Category: General Medicine Authors: Tanizawa, K., Nishimura, Y., Sera, S., Yaguchi, D., Okada, A., Nishikawa, M., Tamaru, S., Nagai, N. Tags: Open access, Epidemiology Source Type: research

How common is isolated dysphasia among patients with stroke treated with intravenous thrombolysis, and what is their outcome? Results from the SITS-ISTR
Conclusions A low proportion of patients with isolated dysphasia are treated with IVT. Half of these patients were fully recovered at 7 days.
Source: BMJ Open - November 25, 2015 Category: Journals (General) Authors: Lundström, E., Zini, A., Wahlgren, N., Ahmed, N. Tags: Open access, Cardiovascular medicine, Neurology Research Source Type: research

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