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Source: Heart Rhythm
Condition: Atrial Fibrillation

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Total 356 results found since Jan 2013.

Ce-454029-4 racial disparities in the use of oral anticoagulation for atrial fibrillation by sex and within high and low stroke risk populations
Atrial fibrillation (AF) is the most common arrhythmia and is associated with an increased risk of ischemic stroke. Oral anticoagulation (OAC) has been shown to reduce the risk of ischemic stroke in patients with AF. Previous studies have demonstrated that both females and Black, Hispanic, and Asian groups are less likely to be prescribed OAC.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: William Tate, Grace Ha, Leon M. Ptaszek, Dolphurs Hayes, James M. Alzate, Joseph R. Betancourt, Jason H. Wasfy, Malissa J. Wood, Moussa Mansour Source Type: research

Ce-452778-1 left atrial mechanical dysfunction and the incidence of atrial fibrillation within 1 year of embolic stroke of unknown source
Atrial fibrillation (AF) is detected in a significant proportion of patients with embolic stroke of unkown source (ESUS) on subsequent cardiac monitoring and represents an indication for anticoagulation to prevent future stroke in these patients. Left atrial mechanical dysfunction often precedes development of atrial fibrillation and may represent an upstream marker which can readily be assessed at the point of care to inform decisions about future stroke prevention in people with ESUS.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Ravi S. Shah, Joseph Raco, Ryan Williams, Michael Farbaniec, Nathaniel D. McConkey, Kevin J. Mills, ankit maheshwari Source Type: research

Ci-452768-1 impact of new-onset atrial fibrillation detected by cardiac implantable electronic devices on cardioembolic stroke events
The association between atrial fibrillation (AF) detected by implanted cardiac implantable electronic devices (CIEDs) and the incidence of cardioembolic stroke events has been reported. However, the cut-off value of new-onset AF duration detected by CIEDs for cardioembolic stroke is still unknown. In previous studies regarding the cut-off value of AF duration, patients who had a history of AF or had received anticoagulant therapies were also included. Therefore, the solo effect of AF on the risk of cardioembolic stroke cannot be reliably evaluated on these studies.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Miyo Nakano, Yusuke Kondo, Masahiro Nakano, Takatsugu Kajiyama, Ryo Ito, Mari Kitagawa, Toshinori Chiba, Satoko Ryuzaki, Yutaka Yoshino Source Type: research

Ce-452780-3 predictors of atrial fibrillation recurrence in cardiac and non-cardiac patients with post-operative atrial fibrillation
Post-operative atrial fibrillation (POAF) is new onset atrial fibrillation (AF) that occurs within 90 days of surgical procedure. Its underlying mechanism is believed to be related to factors such as inflammation, adrenergic surplus, infections and hypoxia. The predictors of AF recurrence in POAF population are not well defined. Establishing potential predictors of AF recurrence in POAF patients could help clinicians identify patients who are at increased risk of stroke and other complications.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Ayesha Shaik, Maciej Tysarowski, Sana Riaz, Karthik Gonuguntla, Jeffrey Mather, Adaya Weissler-Snir Source Type: research

Bs-452758-4 combined gene therapy approach targets parasympathetic signaling and oxidative stress to attenuate persistent atrial fibrillation development in a canine model
Atrial fibrillation (AF) is the most common arrhythmia, a major risk factor for stroke and is associated with substantial morbidity and mortality. Unfortunately, current pharmacological and interventional treatment approaches are suboptimal. Parasympathetic nervous system (PNS) activity upregulation and oxidative stress (OS), mainly generated by NADPH oxidase 2 (NOX2), have been shown as key players in AF induction and maintenance. A deeper understanding of these molecular mechanisms underlying AF and their interplay will be instrumental to the development of new, mechanism-targeted therapies for AF.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Aleksei Mikhailov, Azaria Panni, Anna Pfenniger, Shin Yoo, David Johnson, Wenwei Zhang, Markus Rottmann, William Marszalec, Asish Ghosh, Rod S. Passman, Bradley P. Knight, Rishi Arora Source Type: research

Morbid Obesity is Associated with Increased Procedural Complications and Worse In-Hospital Outcomes after Percutaneous Left Atrial Appendage Occlusion Device Implantation
Obesity has adverse effects on cardiovascular hemodynamics and is an independent risk factor for the induction and perpetuation of atrial fibrillation (AF) (1). Percutaneous left atrial appendage occlusion (LAAO) has shown promising results in reducing stroke risk in select AF patients who cannot be managed with a conventional long-term oral anticoagulation strategy (2). In the landmark PROTECT-AF trial evaluating the efficacy and safety of percutaneous LAAO, patients receiving LAAO device had a mean BMI of 31.6 kg/m2 (2), however, no distinct assessment of outcomes were conducted based on body weight.
Source: Heart Rhythm - December 26, 2022 Category: Cardiology Authors: Siddharth Agarwal, Zain Ul Abideen Asad, Muhammad Zia Khan, Lydia Fekadu Messele, Douglas Darden, Deepak Kumar Pasupula, Gagan D. Singh, Uma N. Srivatsa, Salman Zahid, Sudarshan Balla, Christopher V. DeSimone, Abhishek Deshmukh, Muhammad Bilal Munir Source Type: research

Electrocardiographic P terminal force in lead V1, its components, and the association with stroke and atrial fibrillation or flutter
The electrocardiographic (ECG) marker P terminal force V1 (PTFV1) is generally perceived as a marker of left atrial pathology and has been associated with atrial fibrillation or flutter (AF).
Source: Heart Rhythm - November 23, 2022 Category: Cardiology Authors: Lecia Dixen Wolder, Claus Graff, Kirstine H. Baadsgaard, Monica Lykke Langgaard, Christoffer Polcwiartek, Christina Ji-Young Lee, Morten Wagner Skov, Christian Torp-Pedersen, Daniel J. Friedman, Brett Atwater, Thure Filskov Overvad, Jonas Bille Nielsen, S Source Type: research

The Electrocardiographic P Terminal Force in Lead V1, Its Components and the Association with Stroke and Atrial Fibrillation or Flutter
ECG marker P Terminal Force V1 (PTFV1) is generally perceived as a marker of left atrial pathology and has been associated with atrial fibrillation or flutter (AF).
Source: Heart Rhythm - November 23, 2022 Category: Cardiology Authors: Lecia Dixen Wolder, Claus Graff, Kirstine H. Baadsgaard, Monica Lykke Langgaard, Christoffer Polcwiartek, Christina Ji-Young Lee, Morten Wagner Skov, Christian Torp-Pedersen, Daniel J. Friedman, Brett Atwater, Thure Filskov Overvad, Jonas Bille Nielsen, S Source Type: research

Contemporary Trends in Utilization and Outcomes of Percutaneous Left Atrial Appendage Occlusion in the United States from 2016 to 2019
Atrial fibrillation is a major cause of stroke and thromboembolism and oral anticoagulation is the mainstay of prevention. In patients who are poor candidates for long-term anticoagulation, percutaneous left atrial appendage occlusion (pLAAO) emerged as an alternative stroke prevention strategy and was approved by the US FDA in 2015. We aimed to examine trends in procedural volume, resource utilization, and clinical outcomes of pLAAO from a nationally representative cohort.
Source: Heart Rhythm - October 14, 2022 Category: Cardiology Authors: Mohak Gupta, Abdul Mannan Khan Minhas, Sachin S. Goel, Sourbha S. Dani, Mahboob Alam, Salik Nazir, Safi U. Khan, Wilbert Aronow, Vardhmaan Jain Source Type: research

Improving guideline-based anticoagulation in atrial fibrillation: A systematic literature review of prospective trials
Guidelines for anticoagulation in patients with atrial fibrillation (AF) aim to decrease the risk of ischemic stroke. However, there is a gap in actual practice between patients who have an indication for anticoagulation and those who are actually prescribed anticoagulation.
Source: Heart Rhythm - September 16, 2022 Category: Cardiology Authors: Zachary A. Sporn, Adam N. Berman, Danielle Daly, Jason H. Wasfy Source Type: research

Performing Transcatheter Left Atrial Appendage Closure: Techniques and Challenges
The left atrial appendage (LAA) has been demonstrated to be the major source of thromboemboli in patients with atrial fibrillation (AF).1 The rationale of LAA closure is based on eliminating LAA continuity with the left atrium thereby reducing stroke risk. Indeed, left atrial appendage occlusion (LAAO) procedures play an important role in anticoagulation-intolerant patients at risk for AF-related stroke. Based on the PROTECT-AF2 and PREVAIL3 studies, the Food and Drug Administration (FDA) approved use of the Watchman (Boston Scientific, MA) device in 2015, with an updated generation of device subsequently ratified in 2020 ...
Source: Heart Rhythm - August 6, 2022 Category: Cardiology Authors: Ammar M. Killu, Mohamad A. Alkhouli Source Type: research

Anticoagulation Management and Risk of Thromboembolism in Healthy Youth with Atrial Fibrillation: Data from a Multi-Institutional PACES Collaborative Registry
Stroke is a well-defined complication of atrial fibrillation (AF) in adults. Risks and benefits of anticoagulation management in this patient population are extensively studied resulting in well-defined clinical practice guidelines.1 On the other hand, there is limited data in healthy children and young adults.
Source: Heart Rhythm - August 3, 2022 Category: Cardiology Authors: Iqbal El Assaad, Benjamin H. Hammond, Peter F. Aziz, Participating Members of the Pediatric and Congenital Electrophysiology Society, Christopher Janson, Elizabeth Dr Sherwin, Elizabeth A. Stephenson, Christopher L. Johnsrude, Mary Niu, Ira Shetty, David Source Type: research

Atrial fibrillation after transcatheter patent foramen ovale closure: To measure is to know
A patent foramen ovale (PFO) results from an incomplete fusion of the septum primum and secundum at birth.1 The prevalence of a PFO in the adult population has been estimated at approximately 25%, but this rate was highly dependent on the diagnostic modality used and selection bias by including a disproportionate number of patients with previous cryptogenic stroke in comparative studies.2 The causal relation between cryptogenic stroke and the presence of a PFO has long been debated, yet with rates up to 40% the prevalence for PFOs is significantly higher in patients with cryptogenic stroke.
Source: Heart Rhythm - May 25, 2022 Category: Cardiology Authors: Bert Vandenberk, Carlos A. Morillo Tags: Editorial Commentary Source Type: research

Atrial Fibrillation after Transcatheter PFO Closure – To Measure Is To Know
A patent foramen ovale (PFO) results from an incomplete fusion of the septum primum and secundum at birth.1 The prevalence of a PFO in the adult population has been estimated at approximately 25%, but this rate was highly dependent on the diagnostic modality used and selection bias by including a disproportionate number of patients with prior cryptogenic stroke in comparative studies.2 The causal relation between cryptogenic stroke and the presence of a PFO has long been debated, yet with rates up to 40% the prevalence for PFOs is significantly higher in patients with cryptogenic stroke.
Source: Heart Rhythm - May 25, 2022 Category: Cardiology Authors: Bert Vandenberk, Carlos A. Morillo Source Type: research

Po-640-08 clinical impact of unhealthy lifestyle in patients with atrial fibrillation having low-risk for stroke
Unhealthy lifestyle may contribute to poor clinical outcomes in patients with atrial fibrillation (AF).
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Sun-hwa Kim, Hyo-Jeong Ahn, Seung woo Lee, kyungdo han, Seil Oh, Gregory Lip Source Type: research