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Lb-456091-2 dynamic data driven management of atrial fibrillation using implantable cardiac monitors – the monitor af study
Management of atrial fibrillation (AF) is often complex and dynamic. Clinical decisions related to initiation of rate control, rhythm control strategies, stroke prophylaxis measures depend on the assessment of the presence and the burden of AF. Assessment of therapy outcomes and withdrawl of drugs and anticoagulation are guided by AF monitoring. Implantable cardiac monitors (ICM) are excellent tools to detect and monitor AF burden in a dynamic fashion. We prospectively studied if the presence of an ICM impacts the management of AF and there by clinical outcomes.
Source: Heart Rhythm - May 16, 2023 Category: Cardiology Authors: Dhanunjaya R. Lakkireddy, Jalaj Garg, Adnan Ahmed, Danish Bawa, Rajesh Kabra, Douglas Darden, Rakesh Gopinathannair, Naga Venkata K. Pothineni, Poojita Shivamurthy, Scott Koerber, Peter H. Park, Chandrasekhar R. Vasamreddy, Rangarao V. Tummala, Donita Atk Source Type: research

Ce-454029-4 racial disparities in the use of oral anticoagulation for atrial fibrillation by sex and within high and low stroke risk populations
Atrial fibrillation (AF) is the most common arrhythmia and is associated with an increased risk of ischemic stroke. Oral anticoagulation (OAC) has been shown to reduce the risk of ischemic stroke in patients with AF. Previous studies have demonstrated that both females and Black, Hispanic, and Asian groups are less likely to be prescribed OAC.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: William Tate, Grace Ha, Leon M. Ptaszek, Dolphurs Hayes, James M. Alzate, Joseph R. Betancourt, Jason H. Wasfy, Malissa J. Wood, Moussa Mansour Source Type: research

Po-01-167 efficacy of botulinum toxin type a (agn-151607) for the prevention of postoperative atrial fibrillation in cardiac surgery patients: atrial fibrillation and anticoagulation results from the phase 2 nova study
Oral anticoagulation reduces the risk of stroke but also increases the risk of bleeding. Prevention of post-operative atrial fibrillation (POAF) could result in a lower burden of oral anticoagulation and bleeding events. AGN-151607 has been proposed to prevent POAF and its safety/efficacy was tested in a multicenter randomized trial.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Nathan Waldron, Alexandra OSullivan, Jonathan P. Piccini, Matthew Romano, Pierre Voisine, Wilson Titanji, Richard Leaback, William Ferguson, Jonathan S. Steinberg Source Type: research

Po-01-140 atrial fibrillation and septic shock: a five-year retrospective observational study of anticoagulation usage, bleeding and stroke rates
Anticoagulation (AC) for atrial fibrillation (AF) is a cornerstone of management, and the benefit of mitigating stroke risk is accompanied by an increased risk of bleeding. The risk and benefit of AC in septic shock remains unclear as this disruptive hyperinflammatory state leads to multi-organ dysfunction, which can include coagulopathies.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Jonathan Na, Joanne Moon, Sahitya Allam, Maria Abraham, Kevin Chen, Ethan Kotloff, Yash Desai, Simin Hossain, Christopher Messner, Elnaz Esmati, Thomas Kutner, Gregory Norcross, James Childress, Paul Han, Ian Welch, Michael Sokolow, Libin Wang, Vincent Se Source Type: research

Po-02-192 new onset, recurrence and progression of atrial fibrillation after cardiac surgery during 2.5 years of continuous rhythm monitoring
Atrial fibrillation (AF) in the early postoperative phase (POAF) is a frequent complication after cardiac surgery which is also associated with late AF-recurrences. However, it is unknown how POAF-burden (percentage of time in AF) progresses in the time following surgery. Recent studies suggested that AF-burden is associated with increased risk of stroke and therefore identifying factors associated with a higher POAF-burden is desirable.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Michal Kawczynski, Martijn D. Gilbers, Stef Zeemering, Aaron Isaacs, Jos Maessen, Sander Verheule, Elham Bidar, Ulrich Schotten Source Type: research

Po-03-175 cost-effectiveness of transesophageal echocardiogram prior to atrial fibrillation ablation.
With universal adoption of uninterrupted anticoagulation (AC) it is suggested that transesophageal echo (TEE) screening for LA (left atrial) thrombus prior to AF ablation procedure could be omitted. Observational studies suggest that post-procedure stroke might not be completely prevented by TEE. Accumulating data on safety of AF ablation on uninterrupted AC together with a risk of TEE complications raise the question of indications for TEE in all AF ablation patients.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Olga Reynbakh, Clyde B. Schechter, Mario J. Garcia, Leandro Slipczuk Bustamante, Hardikkumar Patel, Xiaodong Zhang, Fengwei Zou, Luigi Di Biase Source Type: research

Dh-452784-2 identifying atrial fibrillation with sinus rhythm electrocardiogram using artificial intelligence in embolic stroke with undetermined source
Previous studies have demonstrated acceptable ranges of accuracy of artificial intelligence (AI) algorithms for identifying patients with paroxysmal atrial fibrillation (AF) based on their sinus rhythm electrocardiograms (ECGs). However, none of them has been validated in patients with embolic stroke with undetermined source (ESUS) in which thorough AF screening is required.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Ji Hyun Lee, Youngjin Cho, Joonghee Kim Source Type: research

Po-03-190 safety and outcomes of left atrial appendage occlusion in nonagenarians
As the human lifespan continues to lengthen, so too will the incidence of atrial fibrillation and the need for anticoagulation for stroke prevention. However, many of these patients that require anticoagulation are also at high risk of bleeding making left atrial appendage occlusion (LAAO) an attractive option. Studies on the procedural risks in the very elderly are limited and the safety of LAAO in nonagenarians is lacking.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Anis John Kadado, Alexandra Marenco, Jishu Motta, Khalid Sawalha, Kyle Gobeil, Michel Farah, Guy Rozen, Marshal Fox, Fadi M. Chalhoub Source Type: research

Po-05-218 atrial myopathy forms the substrate for ischemic stroke in patients without atrial fibrillation: secondary analysis of topcat trial.
Around 25% of all ischemic strokes do not have an etiology despite a complete standardized diagnostic workup. Recent studies emphasized the effect of atrial dysfunction on arrhythmogenesis and thrombogenesis. At present, there is a lack of a direct link between atrial myopathy and ischemic stroke independently of atrial fibrillation (AF).
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Kassem Farhat, Khaled Elkholey, Stavros Stavrakis Source Type: research

Po-05-197 association of genetic risk of atrial fibrillation and dementia
Atrial fibrillation (AF) has been suggested as a risk factor for dementia since it may lead to chronic cerebral hypoperfusion and stroke. However, precise mechanism of this association is not well-known and studies that examine the association of genetic susceptibility of AF and dementia is scarce.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Dongmin Kim, Juntae Kim, Eunsun Jang, Daehoon Kim, Hee Tae Yu, Myung-Yong Lee, Pil-Sung Yang, Boyoung Joung Source Type: research

Ci-452768-1 impact of new-onset atrial fibrillation detected by cardiac implantable electronic devices on cardioembolic stroke events
The association between atrial fibrillation (AF) detected by implanted cardiac implantable electronic devices (CIEDs) and the incidence of cardioembolic stroke events has been reported. However, the cut-off value of new-onset AF duration detected by CIEDs for cardioembolic stroke is still unknown. In previous studies regarding the cut-off value of AF duration, patients who had a history of AF or had received anticoagulant therapies were also included. Therefore, the solo effect of AF on the risk of cardioembolic stroke cannot be reliably evaluated on these studies.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Miyo Nakano, Yusuke Kondo, Masahiro Nakano, Takatsugu Kajiyama, Ryo Ito, Mari Kitagawa, Toshinori Chiba, Satoko Ryuzaki, Yutaka Yoshino Source Type: research

Po-05-185 prediction and risk of atrial fibrillation in patients with hypertrophic cardiomyopathy: a danish nationwide cohort study
Hypertrophic cardiomyopathy (HCM) can be associated with serious complications such as heart failure, atrial fibrillation (AF) and sudden cardiac death. The treatment of AF in HCM patients can be challenging since AF often aggravates symptoms and increases the risk of stroke. Little is known on which factors contribute to the development of AF in these patients.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Christopher Z örner, Jannik L. Pallisgaard, Anne-Marie Schjerning, Morten K. Jensen, Jacob Tønnesen, Lise D. Vestergaard, Peter Vibe Rasmussen, Gunnar Gislason, Morten L. Hansen Source Type: research

Po-01-219 combination of early rhythm control and healthy lifestyle on the risk of stroke in elderly patients with new-onset atrial fibrillation: a korean nationwide population-based cohort study
Early rhythm control and lifestyle modification have both been associated with a lower risk of stroke in patients with atrial fibrillation (AF). However, the impact of early rhythm control strategy in combination with lifestyle modification on the risk of stroke is less clear in elderly population.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Woo-Hyun Lim, So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Seil Oh, Gregory Lip Source Type: research

Po-05-136 in stroke patients, do baseline electrocardiogram findings correlate with diagnostic findings on long-term monitoring with implantable loop recorder?
In patients with cryptogenic stroke, long-term monitoring is standard-of-care to exclude atrial tachyarrhythmias. Prior studies have not examined interatrial block (IAB) and other ECG markers paired with long-term continuous monitoring (the current gold standard) to predict likelihood of atrial fibrillation (AF) detection in stroke patients.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Matthew D. Henriques, Chad Gier, Mohammed Al-Sadawi, Faisal Aslam, Abhijeet Singh, Ibrahim O. Almasry, Eric J. Rashba, Roger Fan Source Type: research

Performing Transcatheter Left Atrial Appendage Closure: Techniques and Challenges
The left atrial appendage (LAA) has been demonstrated to be the major source of thromboemboli in patients with atrial fibrillation (AF).1 The rationale of LAA closure is based on eliminating LAA continuity with the left atrium thereby reducing stroke risk. Indeed, left atrial appendage occlusion (LAAO) procedures play an important role in anticoagulation-intolerant patients at risk for AF-related stroke. Based on the PROTECT-AF2 and PREVAIL3 studies, the Food and Drug Administration (FDA) approved use of the Watchman (Boston Scientific, MA) device in 2015, with an updated generation of device subsequently ratified in 2020 ...
Source: Heart Rhythm - August 6, 2022 Category: Cardiology Authors: Ammar M. Killu, Mohamad A. Alkhouli Source Type: research

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