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Selected Health and Life Style Factors and Time to Phenoconversion in Huntington's Disease (S47.003)
CONCLUSIONS: An association between total lifetime caffeinated soda consumption and earlier HD onset was observed, but this was not seen with other caffeinated beverages and may be spurious. Other life style risk factors associated with PD or AD did not modify time to phenoconversion in HD.SUPPORT: NIH (# 2 R01 HG002449-06), National Human Genome Research Institute, National Institute of Neurological Disorders and StrokeDisclosure: Dr. Tanner has received personal compensation for activities with AbbVie and Adamas Pharmaceuticals as a scientific advisor. Dr. Marder has received personal compensation in an editorial capacit...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Tanner, C., Marder, K., Eberly, S., Biglan, K., Oakes, D., Shoulson, I. Tags: Movement Disorders: Huntington ' s Disease, Ataxia, and Wilson Source Type: research

Spinning Out of Control: The Black Box of Basilar and Hemiplegic Migraine (P7.176)
CONCLUSIONS:In this retrospective study, triptans were used effectively with no subsequent vascular events for the abortive treatment of migraines with basilar and hemiplegic features. This data also suggests that beta blockers, tricyclic anti-depressants, anti-convulsants, and Botox injections have some efficacy in the treatment of migraines with basilar type and hemiplegic features.Disclosure: Dr. Krel has nothing to disclose. Dr. Mathew has nothing to disclose. Dr. Spinner has received personal compensation for activities with Merz Pharma and Allergan Inc. as speaker bureau member. Dr. Joshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Krel, R., Mathew, P., Spinner, W., Joshi, S. Tags: Headache: Treatment Source Type: research

Infarct hemisphere and noninfarcted brain volumes affect locomotor performance following stroke
Conclusion: Individuals with chronic lesions within the right MCA territory, as compared to the left MCA territory, exhibit slower, more asymmetrical gait. For these individuals, larger GM volumes within regions outside of the infarcted vascular territory may help preserve locomotor control.
Source: Neurology - March 10, 2014 Category: Neurology Authors: Chen, I.-H., Novak, V., Manor, B. Tags: MRI, Gait disorders/ataxia, Cerebellum, Basal ganglia, Infarction ARTICLE Source Type: research

Bilateral cerebellar hemorrhage in vermian vein thrombosis
A 67-year-old previously healthy man presented with sudden onset of headache, vomiting, and instability of stance and gait. Neurologic examination demonstrated bilateral dysmetria of the limbs, ataxia, and scanning speech. Neuroimaging showed bilateral cerebellar hemorrhage and altered signal of the superior vermian vein suggestive for thrombosis (figures 1 and 2). Workup for hematologic, coagulation, and immunologic disorders was negative.
Source: Neurology - October 7, 2013 Category: Neurology Authors: Lattanzi, S., Provinciali, L., Silvestrini, M. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage, Cerebral venous thrombosis NEUROIMAGES Source Type: research

Clinical Spectrum and Course in Individuals with Intravascular Large B-Cell Lymphoma Affecting the Nervous System: A Case Series (P01.102)
CONCLUSIONS: Although IVLBL has distinct pathological features, its clinical presentation can be protean, ranging from mild myopathy to fulminant brain or multi-organ failure. The patient's optimal chance for survival relies on early pathological diagnosis and prompt, aggressive chemotherapy.Disclosure: Dr. Zhong has nothing to disclose. Dr. Oakes has nothing to disclose. Dr. Sonnen has nothing to disclose. Dr. Ransom has nothing to disclose. Dr. Longstreth has nothing to disclose. Dr. Mrugala has received personal compensation for activities with UCB Pharma, Sigma-Tau Pharmaceuticals, and Perceptive Informatics. Dr. Mruga...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Zhong, N., Oakes, P., Sonnen, J., Ransom, B., Longstreth, W. T., Mrugala, M. Tags: P01 Neuro-Oncology: Therapeutics Source Type: research

Cerebellar Allocentric and Action-Intentional Spatial Neglect (P01.003)
CONCLUSIONS: The patient's clock drawing and figure drawing errors have been previous described in a patient with cortical dysfunction and this action-intentional neglect is thought to be a form of an action-intentional grasp induced by frontal dysfunction. Alternatively, right hemisphere dysfunction could cause a deficit in global attention, and when performing a focal attentional task of placing and writing clock numbers, she became unaware of the global form on the left side.Disclosure: Dr. Milano has nothing to disclose. Dr. Heilman has received personal compensation for activities with law firms as a consultant. Dr. H...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Milano, N., Heilman, K. Tags: P01 Behavioral Neurology: Attention and Executive Functions Source Type: research

Clinical Features and Management of Ischemic Stroke in Pakistan (P02.031)
CONCLUSIONS: Risk factors for stroke in Pakistan are similar to patients in North America. However the majority of patients are either unaware or have poor management of stroke risk factors. Efforts at risk factor management are important to reduce the burden of stroke in this population.Disclosure: Dr. Khan has nothing to disclose. Dr. Shuaib has nothing to disclose. Dr. Khatri has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Farooq has nothing to disclose. Dr. Mehboob has nothing to disclose. Dr. Khattak has nothing to disclose. Dr. Nazir has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Khan, H., Shuaib, U., Khatri, I., Malik, S., Farooq, U., Mehboob, N., Khattak, J., Nazir, R. Tags: P02 Cerebrovascular Disease II Source Type: research

Poststroke spasticity: Treating to the disability
People who have strokes are subject to numerous potentially devastating sequelae, most often sensorimotor paresis, impairment of cognition and language, and other functional disabilities, including depression and dementia. Of these sequelae, spasticity occurring with motor dysfunction is a frequent finding that has to be evaluated in light of other diagnoses, such as central paresis, ataxia, pathologic stance or gait, and other coordination dysfunctions. Often, spasticity is not notably present in acute ischemic strokes but develops later on, and may then become a major obstacle for achieving independence in performance of...
Source: Neurology - January 14, 2013 Category: Neurology Authors: Brainin, M. Tags: INTRODUCTION Source Type: research

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