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A Contemporary Review on the Genetic Basis of Atrial Fibrillation.
Abstract Atrial fibrillation is the most common sustained cardiac arrhythmia, and affected individuals suffer from increased rates of heart failure, stroke, and death. Despite the enormous clinical burden that it exerts on patients and health care systems, contemporary treatment strategies have only modest efficacy that likely stems from our limited understanding of its underlying pathophysiology. Epidemiological studies have provided unequivocal evidence that the arrhythmia has a substantial heritable component. Subsequent investigations into the genetics underlying atrial fibrillation have suggested that there i...
Source: Methodist DeBakey Cardiovascular Journal - June 17, 2014 Category: Cardiology Authors: Roberts JD, Gollob MH Tags: Methodist Debakey Cardiovasc J Source Type: research

Catheter Ablation for Long-Standing Persistent Atrial Fibrillation.
Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide and represents a major burden to health care systems. Atrial fibrillation is associated with a 4- to 5-fold increased risk of thromboembolic stroke. The pulmonary veins have been identified as major sources of atrial triggers for AF. This is particularly true in patients with paroxysmal AF but not always the case for those with long-standing persistent AF (LSPAF), in which other locations for ectopic beats have been well recognized. Structures with foci triggering AF include the coronary sinus, the left atrial appendage (LAA), the ...
Source: Methodist DeBakey Cardiovascular Journal - April 1, 2015 Category: Cardiology Authors: Romero J, Gianni C, Di Biase L, Natale A Tags: Methodist Debakey Cardiovasc J Source Type: research

Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy
Methodist Debakey Cardiovasc J. 2021 Dec 15;17(5):53-62. doi: 10.14797/mdcvj.1044. eCollection 2021.ABSTRACTSARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), is associated with a bewildering array of cardiovascular manifestations, including myocardial infarction and stroke, myocarditis and heart failure, atrial and ventricular arrhythmias, venous thromboembolism, and microvascular disease. Accumulating evidence indicates that a profound disturbance of endothelial homeostasis contributes to these conditions. Furthermore, the pulmonary infiltration and edema, and later pulmonary fibrosis, in patients with ...
Source: Methodist DeBakey Cardiovascular Journal - January 7, 2022 Category: Cardiology Authors: John P Cooke John H Connor Abhishek Jain Source Type: research

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