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Does the CHA2DS2-VASc score reliably predict atrial arrhythmias? Analysis of a nationwide database of remote monitoring data transmitted daily from cardiac implantable electronic devices
CHA2DS2-VASc is a validated score for predicting stroke in patients with atrial fibrillation (AF).
Source: Heart Rhythm - February 22, 2018 Category: Cardiology Authors: Giovanni Rovaris, Francesco Solimene, Antonio D'Onofrio, Gabriele Zanotto, Renato P. Ricci, Tiziana Mazzella, Saverio Iacopino, Paolo Della Bella, Giampiero Maglia, Gaetano Senatore, Fabio Quartieri, Mauro Biffi, Antonio Curnis, Valeria Calvi, Antonio Rap Source Type: research

Atrial Fibrillation and Cognitive Decline —Another Piece for a Big Puzzle
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is increasing over time.1, 2 AF is associated with an increased risk of stroke,3 heart failure,4 and death.5-7 In recent years, evidence has emerged to indicate that AF is associated with another growing public health problem: cognitive impairment and dementia.8 Although the evidence is compelling, existing studies suffer from several limitations such as reliance on the Mini-Mental State Examination, cross-sectional design, and lack of attention to domain-specific changes.
Source: Heart Rhythm - October 10, 2017 Category: Cardiology Authors: Lin Y. Chen, Win-Kuang Shen Source Type: research

Atrial fibrillation and cognitive decline: Another piece for a big puzzle
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is increasing over time.1,2 AF is associated with an increased risk of stroke,3 heart failure,4 and death.5 –7 In recent years, evidence has emerged to indicate that AF is associated with another growing public health problem: cognitive impairment and dementia.8 Although the evidence is compelling, existing studies suffer from several limitations, such as reliance on the Mini-Mental State Examination, c ross-sectional design, and lack of attention to domain-specific changes.
Source: Heart Rhythm - October 10, 2017 Category: Cardiology Authors: Lin Y. Chen, Win-Kuang Shen Tags: Editorial Commentary Source Type: research

Utility and Limitations of Long-Term Monitoring of Atrial Fibrillation Using an Implantable Loop Recorder
Atrial fibrillation (AF) is the most common cardiac arrhythmia diagnosed and treated in the world. The treatment of patients ’ symptoms as well as the prevention of stroke and heart failure is dependent on accurate detection and characterization of AF. A variety of electrocardiographic (ECG) monitoring techniques are being used for these purposes. However, these intermittent ECG monitoring techniques have been shown to under diagnose AF events, while having limited ability to characterize AF burden and density.
Source: Heart Rhythm - September 13, 2017 Category: Cardiology Authors: Randall Lee, Suneet Mittal Source Type: research

Virchow triad and beyond in atrial fibrillation
Atrial fibrillation (AF), the most common type of arrhythmia in adults, is associated with a 5-fold increase in the incidence of ischemic stroke. Stroke in patients with AF is believed to be mostly cardioembolic caused by left atrial thrombi and is an important cause for hospitalizations and cardiovascular deaths. Although various kinds of direct oral anticoagulants have been developed and used for the prevention hopefully decreasing this fateful event, more knowledge about the left atrial thrombi would be required to improve and refine the pharmacological stroke prevention in AF.
Source: Heart Rhythm - September 7, 2016 Category: Cardiology Authors: Takeshi Yamashita Tags: Editorial Commentary Source Type: research

Pacing for treatment and prevention of atrial fibrillation: Is there an end to this story?Editorial Commentary
Pacemakers are frequently implanted in patients with atrial fibrillation (AF), which is the most common sustained cardiac arrhythmia with causal association with stroke, heart failure, cardiomyopathy, and all-cause mortality.1–5 In a general pacemaker population, AF can also develop frequently and progressively over time.6 Thus, as no surprise, the story of “pacing and AF” has been going around for a long time.1–7 The article by Padeletti et al8 in this issue of HeartRhythm perhaps adds a new twist.
Source: Heart Rhythm - May 5, 2015 Category: Cardiology Authors: Bharat K. Kantharia Tags: Editorial Commentary Source Type: research

Admittance to detect alterations in left ventricular stroke volume
Implantable cardioverter-defibrillators monitor intracardiac electrocardiograms (EGMs) to discriminate between ventricular and supraventricular tachycardias. The incidence of inappropriate shocks remains high because of misclassification of the tachycardia in an otherwise hemodynamically stable individual. Coupling EGMs with an assessment of left ventricular (LV) stroke volume (SV) could help in gauging hemodynamics during an arrhythmia and reducing inappropriate shocks.
Source: Heart Rhythm - June 27, 2014 Category: Cardiology Authors: Erik R. Larson, John E. Porterfield, Sandeep Sagar, Juan Marmol-Velez, Manoj Panday, Daniel Escobedo, Joel Michalek, Yongjian Ouyang, Jonathan W. Valvano, John A. Pearce, Marc D. Feldman Source Type: research

Atrial fibrillation ablation: A death-defying endeavor?
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice.1 In addition to reductions in functional status and quality of life, AF is associated with a significant risk of stroke (increased 5-fold compared to the general population).2 Moreover, because of a combination of altered hemodynamics, AV dyssynchrony, and progressive atrial and ventricular mechanical dysfunction the presence of AF is associated with a doubling in the risk of death independent of other known risk factors, when compared to non-AF controls.
Source: Heart Rhythm - May 21, 2014 Category: Cardiology Authors: Jason G. Andrade, Marc W. Deyell, Laurent Macle Tags: Editorial Commentary Source Type: research

Patients treated with catheter ablation for ventricular tachycardia after an ICD shock have lower long-term rates of death and heart failure hospitalization than do patients treated with medical management only
Background: Ventricular arrhythmias in patients with implantable cardioverter-defibrillators (ICDs) adversely affect outcomes. Antiarrhythmic approaches to ventricular tachycardia (VT) have variable efficacy and may increase risk of ventricular arrhythmias, worsening cardiomyopathy, and death. Comparatively, VT ablation is an alternative approach that may favorably affect outcomes.Objective: To further explore the effect on long-term outcomes after catheter ablation of VT, we compared patients with history of ICD shocks who did not undergo ablation, patients with a history of ICD shocks that underwent ablation, and patient...
Source: Heart Rhythm - December 12, 2013 Category: Cardiology Authors: T. Jared Bunch, J. Peter Weiss, Brian G. Crandall, John D. Day, Heidi T. May, Tami L. Bair, Jeffrey S. Osborn, Charles Mallender, Avi Fischer, Kyle J. Brunner, Srijoy Mahapatra Tags: Ventricular Tachycardia Source Type: research

Left atrial appendage closure: A new technique for clinical practice
Conclusion: This review concludes that it is now appropriate to consider these techniques for patients with AF who are at high risk for stroke for whom effective conventional or novel anticoagulant therapy is not available or who present problems in managing drug treatment.
Source: Heart Rhythm - December 2, 2013 Category: Cardiology Authors: A John Camm, Antonio Colombo, Giorgio Corbucci, Luigi Padeletti Tags: Contemporary Review--Section Editor: Sami Viskin Source Type: research

Increasing time between first diagnosis of atrial fibrillation and catheter ablation adversely affects long-term outcomes
Conclusion: Delays in treatment with catheter ablation impact procedural success rates independent of temporal changes to the AF subtype at ablation.
Source: Heart Rhythm - May 22, 2013 Category: Cardiology Authors: T. Jared Bunch, Heidi T. May, Tami L. Bair, David L. Johnson, J. Peter Weiss, Brian G. Crandall, Jeffrey S. Osborn, Jeffrey L. Anderson, J. Brent Muhlestein, Donald L. Lappe, John D. Day Tags: Clinical Source Type: research

Platelet-derived growth factor: A promising therapeutic target for atrial fibrillation
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is characterized by substantial electrophysiological and structural changes. AF is associated with an increased risk of stroke, heart failure, and overall mortality. The risk of developing AF increases with age and with other risk factors such as diabetes and underlying heart disease. Currently, the therapeutic options for the treatment of AF have moderate effectiveness, and side effects, including proarrhythmic events, can often be encountered. The limited effectiveness of antiarrhythmic drugs available for the management of AF is especially proble...
Source: Heart Rhythm - April 8, 2013 Category: Cardiology Authors: Céline Fiset Tags: Editorial Commentary Source Type: research

MicroRNAs emerging as mediators of remodeling with atrial fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is now established as an independent risk factor for stroke. Moreover, a concomitant diagnosis of AF greatly complicates treatment for a number of disease processes such as diabetes and congestive heart failure. Given the recognized additional burden that AF places on the health-care system, significant research has been performed in an attempt to delineate mechanisms that contribute to AF initiation as well as progression. Understandably, there is an extensive body of research that has identified abnormalities in ionic channels/electrogenic processes that ...
Source: Heart Rhythm - March 25, 2013 Category: Cardiology Authors: Adam W. Akerman, Rupak Mukherjee Tags: Editorial Commentary Source Type: research

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