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Proteomic and other mass spectrometry‐based “Omics” biomarker discovery and validation in pediatric venous thromboembolism and arterial ischemic stroke: Current state, unmet needs, and future directions
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Source: Proteomics. Clinical Applications - October 1, 2014 Category: Biochemistry Authors: Neil A. Goldenberg, Allen D. Everett, David Graham, Timothy J. Bernard, Ulrike Nowak‐Göttl Tags: Review Source Type: research

Proteomic and other mass spectrometry based “omics” biomarker discovery and validation in pediatric venous thromboembolism and arterial ischemic stroke: Current state, unmet needs, and future directions
Venous thromboembolism (VTE) and arterial ischemic stroke (AIS) are increasingly‐recognized health conditions in children, with both acute and chronic sequelae. Risk factors for, and pathogenesis of, VTE are readily related to three principal factors, consisting of venous stasis, endothelial damage, and the hypercoagulable state (i.e. thrombophilia), termed the triad of Virchow. In children, greater than 90% of VTE are provoked by an overt clinical risk factor, the most common of which is a central venous catheter. Risk factors for childhood‐onset (beyond the neonatal period) AIS include sickle cell disease, infection,...
Source: Proteomics. Clinical Applications - December 2, 2014 Category: Biochemistry Authors: Neil A. Goldenberg, Allen D. Everett, David Graham, Timothy J. Bernard, Ulrike Nowak‐Göttl Tags: Review Source Type: research