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Specialty: Neurosurgery
Condition: Thrombosis
Education: Study

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Total 317 results found since Jan 2013.

Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition
Conclusion LAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms.
Source: Journal of NeuroInterventional Surgery - November 18, 2021 Category: Neurosurgery Authors: Fitzgerald, S., Rossi, R., Mereuta, O. M., Jabrah, D., Okolo, A., Douglas, A., Molina Gil, S., Pandit, A., McCarthy, R., Gilvarry, M., Dunker, D., Nordanstig, A., Ceder, E., Redfors, P., Jood, K., Dehlfors, N., Magoufis, G., Tsivgoulis, G., Brinjikji, W., Tags: Open access, Ischemic stroke Source Type: research

Long-term Follow-up Results after Flow Diverter Therapy Using the Pipeline Embolization Device for Large or Giant Unruptured Internal Carotid Artery Aneurysms: Single-center Retrospective Analysis in the Japanese Population
Neurol Med Chir (Tokyo). 2021 Oct 27. doi: 10.2176/nmc.oa.2021-0203. Online ahead of print.ABSTRACTFlow diverter (FD) therapy using Pipeline embolization device (PED) has become an important alternative to treat internal carotid artery (ICA) aneurysms. Herein, we report the long-term outcome for 3 years after FD therapy using PED for ICA aneurysms in Japan. The patients who underwent angiographical and/or clinical follow-up for 3 years after the FD therapy using PED of large or giant unruptured ICA aneurysms from December 2012 at our university hospital are the subjects of this study. We retrospectively reviewed the in- an...
Source: Neurologia Medico-Chirurgica - October 28, 2021 Category: Neurosurgery Authors: Takashi Fujii Kohsuke Teranishi Kenji Yatomi Kazumoto Suzuki Yumiko Mitome-Mishima Akihide Kondo Hidenori Oishi Source Type: research

High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke
Conclusions 3D-SEM provides novel and potentially clinically relevant information on clot components and ultrastructure which may help to inform thrombolytic treatment and medical device design.
Source: Journal of NeuroInterventional Surgery - September 15, 2021 Category: Neurosurgery Authors: Mereuta, O. M., Fitzgerald, S., Christensen, T. A., Jaspersen, A. L., Dai, D., Abbasi, M., Puttappa, T., Kadirvel, R., Kallmes, D. F., Doyle, K. M., Brinjikji, W. Tags: Ischemic stroke Source Type: research

EP46* First pass effect and associated clot characteristics in the EXCELLENT registry - Interim analysis
ConclusionsThe high rate of ‘real-world’ FPE observed in EXCELLENT was associated with improved clinical outcomes. Clots retrieved with FPE had higher RBC and lower fibrin content compared to non FPE and to first pass mTICI <2c/3 e. These preliminary findings await confirmation from analysis of the full dataset.DisclosureEXCELLENT is sponsored by Cerenovus. Dr. Jovin is a consultant for Neuravi, Codman Neurovascular, Stryker (PI DAWN; unpaid), Fundacio Ictus (PI REVASCAT; unpaid), and holds stock in Anaconda, Silk Road, and Blockade Medical.
Source: Journal of NeuroInterventional Surgery - August 24, 2021 Category: Neurosurgery Authors: Jovin, T., Nogueira, R., Siddiqui, A., Yoo, A., Hanel, R., Zaidat, O., Hacke, W., Fiehler, J., De Meyer, S., Brinjikji, W., Doyle, K., Liebeskind, D., Haussen, D., Inoa, V., Humphries, W., Woodward, K., Jabbour, P., Francois, O., Levy, E., Bozorgchami, H. Tags: Treatment Source Type: research

EP63 The TAPAS study: thrombectomy aspiration post-market study in acute stroke
ConclusionThe Q Catheter showed good deliverability and revascularization rates in this real-world setting with no safety concerns.ReferenceLong TD, Kallmes DF, Hanel R, Shigematsu T, Halaszyn AM, Wolter J, Berenstein A. Novel aspiration catheter design for acute stroke thrombectomy. J Neurointerv Surg 2019 Feb;11(2):190–195.DisclosureConsultant MIVI Neuroscience, Inc.
Source: Journal of NeuroInterventional Surgery - August 24, 2021 Category: Neurosurgery Authors: Ballenilla Marco, F., Espinosa, M., Zamarro, J., Masso, J., Garmendia, E., Pumar, J., Larrea, J., Mosqueira, A. Tags: Treatment Source Type: research

In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke
Conclusions An assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.
Source: Journal of NeuroInterventional Surgery - August 13, 2021 Category: Neurosurgery Authors: Itsekson Hayosh, Z., Abu Bandora, E., Shelestovich, N., Nulman, M., Bakon, M., Yaniv, G., Khaitovitch, B., Balan, S., Gerasimova, A., Drori, T., Mausbach, S., Schwammenthal, Y., Afek, A., Chapman, J., Shavit Stein, E., Orion, D. Tags: Ischemic stroke Source Type: research

Effect of bodyweight on VerifyNow Aspirin platelet function test: a retrospective review
Conclusions Bodyweight did not influence the likelihood of obtaining a therapeutic VerifyNow Aspirin result. The clinical utility of obtaining VerifyNow Aspirin assays for this patient population is unknown.
Source: Journal of NeuroInterventional Surgery - August 13, 2021 Category: Neurosurgery Authors: Sandler, M., Hoang, C., Mak, H. Y., Levitt, M. R. Tags: Hemorrhagic stroke Source Type: research

LB-005 The INSIGHT registry: a multi-center, multi-omic stroke clot study, preliminary results
ConclusionThese preliminary results demonstrate the real-world applicability of the INSIGHT study to typical stroke thrombectomy population. Furthermore, the tissue processing protocols are providing high-quality RNA and protein for analysis, which is currently underway.DisclosuresJ. Fraser: 1; C; Penumbra, University of Kentucky. 2; C; Stream Biomedical, Medtronic. 4; C; Cerelux, Fawkes Biotechnology. J. Vicari: None. A. Nanda: None. E. Cheng-Ching: None. K. Woodward: None. B. Rapoport: None. C. Kellner: None.
Source: Journal of NeuroInterventional Surgery - July 29, 2021 Category: Neurosurgery Authors: Fraser, J., Vicari, J., Nanda, A., Cheng-Ching, E., Woodward, K., Rapoport, B., Kellner, C. Tags: Late-breaking oral abstracts Source Type: research

P-007 Safety and efficacy of endovascular thrombectomy for distal vessel occlusion (DLV): single center experience
ConclusionThis single center, consecutive real-world experience demonstrates that thrombectomy in DVO stroke patients is safe and leads to high rate of successful recanalization. Further studies are warranted to evaluate the efficacy of thrombectomy in DVO in comparison to best medical management.Disclosures S. Majidi: None. S. Matsoukas: None. R. De Leacy: None. T. Oxley: None. H. Shoirah: None. T. Shigematsu: None. C. Kellner: None. J. Fifi: None. J. Mocco: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Majidi, S., Matsoukas, S., De Leacy, R., Oxley, T., Shoirah, H., Shigematsu, T., Kellner, C., Fifi, J., Mocco, J. Tags: Oral poster abstracts Source Type: research

P-012 Thrombectomy aspiration post-market study in acute stroke: the TAPAS study
ConclusionThe Q Aspiration Catheter is a novel technology that showed comparable deliverability and revascularization rates as other commercially available catheters with no safety concerns. More prospective clinical data is needed to fully assess the Q Aspiration Catheter.AbbreviationsAIS (acute ischemic stroke), MT (mechanical thrombectomy), ASPECTs (Alberta Stroke Program Early CT Score), mTICI (modified TICI score), NIHSS (National Institute of Health Stroke Scale), mRS (modified Rankin Scale), ENT (embolization to a new territory), sICH (symptomatic intracranial hemorrhage)Disclosures F. Ballenilla: 2; C; MIVI Neurosc...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Ballenilla, F., Espinosa, M., Zamarro, J., Masso, J., Garmendia, E., Pumar, J., Larrea, J., Mosqueira, A. Tags: Oral poster abstracts Source Type: research

P-042 Initial experience with tenecteplase as the intravenous thrombolytic of choice before mechanical thrombectomy for large vessel occlusion acute ischemic stroke
ConclusionIntravenous TNK in patients with LVOAIS is feasible, safe and effective. In our cohort from ‘real world’ patients, TNK was associated with lower need for MT, high recanalization rates and shorter hospitalization.Disclosures U. Ugur: None. S. Platko: None. D. Peters: None. F. Bensabeur: None. J. Terry: None. B. Ludwig: None. E. Cheng-Ching: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Ugur, U., Platko, S., Peters, D., Bensabeur, F., Terry, J., Ludwig, B., Cheng-Ching, E. Tags: Oral poster abstracts Source Type: research

P-052 A novel ex-vivo model to simulate delayed aneurysm rupture after flow-diverter treatment
ConclusionFurther analysis of the tissue samples is underway, in an attempt to quantify the MMP concentration and its correlation to reduced modulus. This study will hopefully lead to the identification of an MMP dose and digestion regimen that can create a reliable benchtop DAR model. A benchtop DAR model would allow for the assessment of new aneurysm treatment options, and the development of new treatment devices for reducing DAR in patients with GIAs.Disclosures H. Sodawalla: None. W. Merritt: None. G. Uyeda: 1; C; ¡MIRA! Exploratory Research AY 2020-21. T. Becker: 1; C; ¡MIRA! Exploratory Research AY 2020-21.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Sodawalla, H., Merritt, W., Uyeda, G., Becker, T. Tags: Oral poster abstracts Source Type: research