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Source: Neurology
Condition: Stroke

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Total 3129 results found since Jan 2013.

Moderate alcohol intake reduces risk of ischemic stroke in Korea
Conclusions: Our findings suggest that light to moderate distilled alcohol consumption may reduce the risk of ischemic stroke in Koreans.
Source: Neurology - November 30, 2015 Category: Neurology Authors: Lee, S. J., Cho, Y.-J., Kim, J. G., Ko, Y., Hong, K.-S., Park, J.-M., Kang, K., Park, T. H., Park, S.-S., Lee, K. B., Cha, J. K., Kim, D.-H., Lee, J., Kim, J.-T., Lee, J., Lee, J. S., Jang, M. S., Han, M.-K., Gorelick, P. B., Bae, H.-J., On behalf of the Tags: All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Case control studies ARTICLE Source Type: research

Arterial ischemic stroke in children with cardiac disease
Conclusions: Infants with cyanotic CHD were most frequently affected by AIS during the periprocedural period. Prospective cohort studies are required to determine effective primary and secondary prevention strategies.
Source: Neurology - December 7, 2015 Category: Neurology Authors: Asakai, H., Cardamone, M., Hutchinson, D., Stojanovski, B., Galati, J. C., Cheung, M. M. H., Mackay, M. T. Tags: Childhood stroke, All Cerebrovascular disease/Stroke, All Pediatric, Cardiac, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke ARTICLE Source Type: research

The merging burden of HIV infection and stroke in the developing world
According to the WHO, at the end of 2014, the majority of the approximately 36.9 million people living with HIV/AIDS resided in low- to middle-income countries in sub-Saharan Africa.1 The same report indicated that cases in sub-Saharan Africa account for almost 70% of the global total of new HIV infections.1 The burden of stroke in developing countries parallels that of HIV/AIDS. Approximately 80% of people who have had a stroke live in low- to middle-income nations.2 Over the past 4 decades, stroke incidence in these countries has increased by more than 100%.3 In developing nations, HIV/AIDS and stroke are not mutually ex...
Source: Neurology - January 25, 2016 Category: Neurology Authors: Behrouz, R., Gottesman, R. F. Tags: Stroke in young adults, HIV, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Statin therapy in acute ischemic stroke: Time for large randomized trials?
Despite improvements in stroke mortality coupled with therapeutic advances, stroke patients often face the prospect of substantial disability. Novel strategies are clearly needed to further improve stroke outcomes. These might include new indications for previously licensed drugs proven effective and safe in related disease processes,1 such as statins. Unlike strong evidence supporting statin use in cardiovascular risk reduction and acute myocardial ischemia, their effects on cerebral tissue and potential benefits on stroke outcomes remain poorly understood and understudied. The only current stroke-specific indication for ...
Source: Neurology - March 21, 2016 Category: Neurology Authors: Charidimou, A., Merwick, A. Tags: All Cerebrovascular disease/Stroke, Infarction EDITORIALS Source Type: research

Association of Hemoglobin A1c and Baseline Ischemic Stroke Severity: A Population-Based Study (P1.187)
Conclusions: We found that elevated HbA1c was associated with decreased stroke severity at presentation. However, this effect is mediated by the history of DM rather than a specific dose-effect of glycemic control. Our results provide evidence that although chronic hyperglycemia increases risk of stroke, it is not associated with increased stroke severity.Disclosure: Dr. Yang has nothing to disclose. Dr. Khoury has nothing to disclose. Dr. Alwell has nothing to disclose. Dr. Moomaw has received research support from the National Institutes of Health. Dr. Yeramaneni has nothing to disclose. Dr. Woo has received research sup...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Yang, Y., Khoury, J., Alwell, K., Moomaw, C., Yeramaneni, S., Woo, D., Flaherty, M., Adeoye, O., Ferioli, S., De Los Rios La Rosa, F., Kissela, B., Kleindorfer, D. Tags: Ischemic Stroke Outcomes Source Type: research

Palliative Care Consultation Did Not Reduce Length of Stay in a Comprehensive Stroke Center (P1.212)
Conclusion: Palliative care consultation for patients with ischemic or hemorrhagic strokes was not associated with decreased hospital costs or LoS. This is in contrast to previously reported studies. We will further analyze the effect of early palliative care on a larger sample size to validate the findings. We also propose that a standardized palliative care trigger tool be implemented for early PC consultation in patients with debilitating stroke, advanced age, and multiple comorbid conditions.Disclosure: Dr. Tversky has nothing to disclose. Dr. Cheng has nothing to disclose. Dr. Mahmud has nothing to disclose. Dr. Schlo...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Tversky, S., Cheng, D., Mahmud, S., Schloss, E., Wright, P. Tags: Re-admission and Stroke Outcomes Source Type: research

Delays in the Emergency Department, Medical Complications of Stroke and Predictors of Clinical Outcomes: The McGill Experience (P2.310)
Conclusions: This preliminary analysis of our cohort reveals that there is a significant delay in the admission of patients from the ED to the stroke unit, and that this delay is not in keeping with current Canadian Stroke Best Practice guidelines. Medical complications were prevalent, and pneumonia, brain edema and sepsis during admission were associated with worse clinical outcomes. Further work will explore the correlation between delays in ED, medical complications and clinical outcomes. Conclusions:Disclosure: Dr. Chen has nothing to disclose. Dr. Cote has nothing to disclose. Dr. Vieira has nothing to disclose. Dr. B...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Chen, B. Y., Cote, R., Vieira, L., Benjamin, L., Legault, C. Tags: Stroke Systems of Care Source Type: research

Does Transferring Patients to Stroke Centers Increase Length of Stay (P2.313)
Conclusions: There was no difference in LOS or any clinical outcomes between the ED and transferred patients. Additionally, transferred patients did not receive more advanced procedures such as intra-arterial therapy or hemicraniectomy. Further studies exploring non-tPA patients and transient ischemic attack patients would be informative, as well as non-home, discharge location relative to the patient’s residence.Disclosure: Dr. Cossey has nothing to disclose. Dr. Bozorgui has nothing to disclose. Dr. Jagolino has nothing to disclose. Dr. Vahidy has nothing to disclose. Dr. Wu has received personal compensation for a...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Cossey, T., Bozorgui, S., Jagolino, A., Vahidy, F., Wu, T. C., Savitz, S. Tags: Stroke Systems of Care Source Type: research

Prothrombotic States and Ischemic Stroke in the Young (P3.231)
Conclusions: There is no association between prothrombotic risk factors (analyzed individually or as a group) and idiopathic ischemic stroke in the young, even in those with a PFO or with migraine.Disclosure: Dr. Boudjani has nothing to disclose. Dr. Lanthier has received compensation for activities with Bristol-Myers-Squibb, Sanofi-Aventis, Boehringer-Ingelheim, and Astra-Zeneca as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Boudjani, H., Lanthier, S. Tags: Stroke in the Young Source Type: research

Effect of two 12-minute culturally targeted films on intent to call 911 for stroke
Conclusions: Narrative communication in the form of tailored short films may improve intent to call 911 for stroke among the black and Hispanic population.
Source: Neurology - May 22, 2016 Category: Neurology Authors: Williams, O., Leighton-Herrmann, E., DeSorbo, A., Eimicke, J., Abel-Bey, A., Valdez, L., Noble, J., Gordillo, M., Ravenell, J., Ramirez, M., Teresi, J. A., Jean-Louis, G., Ogedegbe, G. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Practice advisory: Recurrent stroke with patent foramen ovale (update of practice parameter): Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Conclusions: Percutaneous PFO closure with the STARFlex device possibly does not provide a benefit in preventing stroke vs medical therapy alone (risk difference [RD] 0.13%, 95% confidence interval [CI] –2.2% to 2.0%). Percutaneous PFO closure with the AMPLATZER PFO Occluder possibly decreases the risk of recurrent stroke (RD –1.68%, 95% CI –3.18% to –0.19%), possibly increases the risk of new-onset atrial fibrillation (AF) (RD 1.64%, 95% CI 0.07%–3.2%), and is highly likely to be associated with a procedural complication risk of 3.4% (95% CI 2.3%–5%). There is insufficient evidence to d...
Source: Neurology - August 21, 2016 Category: Neurology Authors: Messe, S. R., Gronseth, G., Kent, D. M., Kizer, J. R., Homma, S., Rosterman, L., Kasner, S. E. Tags: All Cerebrovascular disease/Stroke SPECIAL ARTICLE Source Type: research

Role of atherosclerosis, clot extent, and penumbra volume in headache during ischemic stroke
Conclusions: Headache in the early phase of ischemic stroke tends to occur less often in patients with atherosclerosis than in patients without atherosclerosis in the large cerebral arteries. This finding lends support to the hypothesis that vessel wall elasticity is a necessary contributing factor in the occurrence of headache during acute ischemic stroke.
Source: Neurology - September 11, 2016 Category: Neurology Authors: van Os, H. J. A., Mulder, I. A., van der Schaaf, I. C., Kappelle, L. J., Velthuis, B. K., Broersen, A., Vos, J. A., Terwindt, G. M., Schonewille, W., Ferrari, M. D., Algra, A., van Walderveen, M. A. A., Wermer, M. J. H. Tags: All Headache, CT, All Clinical Neurology, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study
Conclusions: Higher levels of 4 biomarkers—CRP, tHcy, TNFR2, and VEGF—increased risk of IIS and improved the predictive ability of the Framingham Stroke Risk Profile score. Further research is warranted to explore their role as potential therapeutic targets.
Source: Neurology - September 18, 2016 Category: Neurology Authors: Shoamanesh, A., Preis, S. R., Beiser, A. S., Kase, C. S., Wolf, P. A., Vasan, R. S., Benjamin, E. J., Seshadri, S., Romero, J. R. Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Cohort studies, Incidence studies, Infarction ARTICLE Source Type: research

Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke
Conclusions: Let7i is decreased in circulating leukocytes of patients with acute ischemic stroke. Mechanisms by which let7i regulates inflammatory response post stroke include targeting CD86, CXCL8, and HMGB1.
Source: Neurology - November 20, 2016 Category: Neurology Authors: Jickling, G. C., Ander, B. P., Shroff, N., Orantia, M., Stamova, B., Dykstra-Aiello, C., Hull, H., Zhan, X., Liu, D., Sharp, F. R. Tags: All Cerebrovascular disease/Stroke, Gene expression studies, Infarction ARTICLE Source Type: research

DCE-MRI blood-brain barrier assessment in acute ischemic stroke
Conclusion: BBB in acute stroke patients can be successfully assessed quantitatively. The decrease of BBB permeability in unaffected regions at follow-up may be an indicator of global BBB leakage even in vessel territories remote from the index infarct.
Source: Neurology - January 29, 2017 Category: Neurology Authors: Villringer, K., Sanz Cuesta, B. E., Ostwaldt, A.-C., Grittner, U., Brunecker, P., Khalil, A. A., Schindler, K., Eisenblätter, O., Audebert, H., Fiebach, J. B. Tags: Diagnostic test assessment, MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research