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Source: Brain
Condition: Pain
Nutrition: Calcium
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The neurology of itch
Research over the past 15 years has helped to clarify the anatomy and physiology of itch, the clinical features of neuropathic itch syndromes and the scientific underpinning of effective treatments. Two itch-sensitive pathways exist: a histamine-stimulated pathway that uses mechanically insensitive C-fibres, and a cowhage-stimulated pathway primarily involving polymodal C-fibres. Interactions with pain continue to be central to explaining various aspects of itch. Certain spinal interneurons (Bhlhb5) inhibit itch pathways within the dorsal horn; they may represent mediators between noxious and pruritic pathways, and allow s...
Source: Brain - February 5, 2014 Category: Neurology Authors: Dhand, A., Aminoff, M. J. Tags: Review Article Source Type: research
