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Republished: Paget's disease of bone: clinical review and update
Paget's disease (PD) is a focal disorder of bone remodelling that occurs commonly in older people. In this article, we review clinical aspects of PD with an emphasis on recent findings. The epidemiology of PD appears to be changing rapidly, with several groups in different parts of the world reporting a marked reduction in the prevalence and incidence of PD, as well as in the severity of disease seen by clinicians. These findings seem most likely to be caused by changes in exposure to unknown environmental factors that have a role in the development of PD. However, genetic factors are also important. Mutations in SQSTM1 oc...
Source: Postgraduate Medical Journal - May 17, 2014 Category: Journals (General) Authors: Bolland, M. J., Cundy, T. Tags: Pain (neurology), Stroke, Breast cancer, Epidemiology, Calcium and bone Republished best practice Source Type: research