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Therapy: Stem Cell Therapy
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Generation of integration-free iPS cell lines from three sickle cell disease patients from the state of Bahia, Brazil
In this study, we generated induced pluripotent stem cell (iPSC) lines from three homozygous SCD patients from the state of Bahia, Brazil, where SCD is highly prevalent. Peripheral blood mononuclear cells were collected and erythroblasts were expanded for cell reprogramming with the use of non-integrative episomal vectors. The generated iPSC lines expressed high levels of pluripotency markers, presented a normal karyotype and were able to differentiate into the three germ layers in embryoid body spontaneous differentiation assays. Moreover, the expression of the episomal vectors was lost in all iPSC lines after 15 passages...
Source: Stem Cell Research - October 4, 2018 Category: Stem Cells Source Type: research
