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Rapid intervention with glyceryl trinitrate in hypertensive stroke trial-2 (right-2): safety and efficacy of transdermal glyceryl trinitrate, a nitric oxide donor
Rationale High blood pressure (BP) is common in acute stroke and is associated with poor outcome. Previous hospital-based trials testing the effects of BP lowering on functional outcome have been inconclusive. The PIL-FAST and RIGHT pilot trials confirmed the feasibility of performing single-centre ambulance-based stroke trials in the UK. In both RIGHT and a subgroup of patients recruited within 6 hours into the large ENOS trial, transdermal glyceryl trinitrate (GTN), a nitric oxide donor, lowered BP and reduced death or disability. Based on these results, RIGHT-2 aims to test the safety and efficacy of transdermal GTN in ...
Source: Emergency Medicine Journal - August 17, 2016 Category: Emergency Medicine Authors: Bath, P. M. W., Dixon, M., Appleton, J., Scutt, P., England, T., Foster, H., Howard, H., Jarvis, M., Montgomery, A., Pocock, S., Potter, J., Price, C., Robinson, T., Roffe, C., Siriwardena, A. N., Sprigg, N., Wardlaw, J. Tags: Poster Presentations Source Type: research