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Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery : An International Randomized Controlled Trial
CONCLUSION: In patients having noncardiac surgery, our hypotension-avoidance and hypertension-avoidance strategies resulted in a similar incidence of major vascular complications.PRIMARY FUNDING SOURCE: Canadian Institutes of Health Research, National Health and Medical Research Council (Australia), and Research Grant Council of Hong Kong.PMID:37094336 | DOI:10.7326/M22-3157
Source: Annals of Internal Medicine - April 25, 2023 Category: Internal Medicine Authors: Maura Marcucci Thomas W Painter David Conen Vladimir Lomivorotov Daniel I Sessler Matthew T V Chan Flavia K Borges Kate Leslie Emmanuelle Duceppe Mar ía José Martínez-Zapata Chew Yin Wang Denis Xavier Sandra N Ofori Michael Ke Wang Sergey Efremov Giova Source Type: research

Measuring the COVID-19 Mortality Burden in the United States : A Microsimulation Study
CONCLUSION: Beyond excess deaths alone, the COVID-19 pandemic imposed a greater life expectancy burden on persons aged 25 to 64 years, including those with average or above-average life expectancies, and a disproportionate burden on Black and Hispanic communities.PRIMARY FUNDING SOURCE: National Institute on Aging.PMID:34543588 | DOI:10.7326/M21-2239
Source: Annals of Internal Medicine - September 20, 2021 Category: Internal Medicine Authors: Julian Reif Hanke Heun-Johnson Bryan Tysinger Darius Lakdawalla Source Type: research

Effect of Intensive Blood Pressure Lowering on Cardiovascular Outcomes: A Systematic Review Prepared for the 2020 U.S. Department of Veterans Affairs/U.S. Department of Defense Guidelines.
CONCLUSION: Overall, current clinical literature supports intensive BP lowering in patients with hypertension for improving cardiovascular outcomes. In most subpopulations, intensive lowering was favored over less-intensive lowering, but the data were less clear for patients with diabetes mellitus or cardiovascular disease. PRIMARY FUNDING SOURCE: U.S. Department of Veterans Affairs, Veterans Health Administration. PMID: 32866419 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - August 31, 2020 Category: Internal Medicine Authors: D'Anci KE, Tipton K, Hedden-Gross A, Rouse B, Hermanson L, Fontanarosa J Tags: Ann Intern Med Source Type: research

Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence.
CONCLUSION: Among patients undergoing PFO closure to prevent future stroke, the presence of residual shunt, particularly a moderate or large residual shunt, was associated with an increased risk for stroke or TIA recurrence. PRIMARY FUNDING SOURCE: National Institutes of Health. PMID: 32422058 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - May 11, 2020 Category: Internal Medicine Authors: Deng W, Yin S, McMullin D, Inglessis-Azuaje I, Elmariah S, Hung J, Lo EH, Palacios IF, Buonanno FS, Ning M Tags: Ann Intern Med Source Type: research

Altered Risk for Cardiovascular Events With Changes in the Metabolic Syndrome Status: A Nationwide Population-Based Study of Approximately 10 Million Persons.
Conclusion: Recovery from MetS was significantly associated with decreased risk for MACE, whereas development of MetS was associated with increased risk. Primary Funding Source: Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea. PMID: 31766057 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - November 25, 2019 Category: Internal Medicine Authors: Park S, Lee S, Kim Y, Lee Y, Kang MW, Han K, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK Tags: Ann Intern Med Source Type: research

Cardiovascular Events and Mortality in White Coat Hypertension: A Systematic Review and Meta-analysis.
Conclusion: Untreated WCH, but not treated WCE, is associated with an increased risk for cardiovascular events and all-cause mortality. Out-of-office BP monitoring is critical in the diagnosis and management of hypertension. Primary Funding Source: National Institutes of Health. PMID: 31181575 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - June 10, 2019 Category: Internal Medicine Authors: Cohen JB, Lotito MJ, Trivedi UK, Denker MG, Cohen DL, Townsend RR Tags: Ann Intern Med Source Type: research

Effect of Variation in Published Stroke Rates on the Net Clinical Benefit of Anticoagulation for Atrial Fibrillation.
Conclusion: Variation in published AF stroke rates for patients not receiving anticoagulant therapy results in multifold variation in the net clinical benefit of anticoagulation. Guidelines should better reflect the uncertainty in current thresholds of stroke risk score for recommending anticoagulation. Primary Funding Source: None. PMID: 30264130 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 25, 2018 Category: Internal Medicine Authors: Shah SJ, Eckman MH, Aspberg S, Go AS, Singer DE Tags: Ann Intern Med Source Type: research

In Chinese adults with hypertension, adding folic acid to enalapril reduced incident stroke.
PMID: 26192588 [PubMed - in process]
Source: Annals of Internal Medicine - July 21, 2015 Category: Internal Medicine Authors: Barer D Tags: Ann Intern Med Source Type: research

Effects of Blood Pressure Reduction in Mild Hypertension: A Systematic Review and Meta-analysis.
Conclusion: Blood pressure-lowering therapy is likely to prevent stroke and death in patients with uncomplicated grade 1 hypertension. Primary Funding Source: Swedish Heart-Lung Foundation, Swedish Research Council, Australian Research Council, and National Health and Medical Research Council of Australia. PMID: 25531552 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - December 23, 2014 Category: Internal Medicine Authors: Sundström J, Arima H, Jackson R, Turnbull F, Rahimi K, Chalmers J, Woodward M, Neal B, on behalf of the Blood Pressure Lowering Treatment Trialists' Collaboration* Tags: Ann Intern Med Source Type: research

Diagnosis of obstructive sleep apnea in adults: a clinical practice guideline from the american college of physicians.
Abstract DESCRIPTION: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the diagnosis of obstructive sleep apnea in adults. METHODS: This guideline is based on published literature on this topic that was identified by using MEDLINE (1966 through May 2013), the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews. Searches were limited to English-language publications. The clinical outcomes evaluated for this guideline included all-cause mortality, cardiovascular mortality, nonfatal cardio...
Source: Annals of Internal Medicine - August 5, 2014 Category: Internal Medicine Authors: Qaseem A, Dallas P, Owens DK, Starkey M, Holty JE, Shekelle P, Clinical Guidelines Committee of the American College of Physicians Tags: Ann Intern Med Source Type: research

Stroke prevention in women: synopsis of the 2014 american heart association/american stroke association guideline.
Abstract DESCRIPTION: In February 2014, the American Heart Association/American Stroke Association released their first guideline focused on stroke prevention in women. This new guideline highlights unique risk factors for stroke in women, including oral contraception and hormone therapy, and pregnancy-associated disorders, such as preeclampsia, that may have long-lasting consequences on a woman's health. It also addresses hypertension; atrial fibrillation; migraine headache with aura; and the epidemiology of types of stroke, such as aneurysmal subarachnoid hemorrhage and cerebral vein thrombosis, that are predomi...
Source: Annals of Internal Medicine - June 17, 2014 Category: Internal Medicine Authors: Bushnell C, McCullough L Tags: Ann Intern Med Source Type: research

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