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Source: Neurology
Condition: Hemorrhagic Stroke

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Total 691 results found since Jan 2013.

Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage
Conclusion: Unlike in ischemic stroke, there was no evidence that patient sex modified the effect of age on 90-day outcomes after ICH in a large multiracial/ethnic population. Future studies should evaluate biological reasons for these differences between stroke subtypes. Clinicaltrials.gov identifier: NCT01202864.
Source: Neurology - September 4, 2017 Category: Neurology Authors: James, M. L., Langefeld, C. D., Sekar, P., Moomaw, C. J., Elkind, M. S. V., Worrall, B. B., Sheth, K. N., Martini, S. R., Osborne, J., Woo, D., On behalf of the ERICH Investigators Tags: Outcome research, Clinical trials Observational study (Cohort, Case control), Intracerebral hemorrhage ARTICLE Source Type: research

Individualized risk prediction of major bleeding in secondary stroke prevention: Are we there yet?
In most patients diagnosed with a TIA or ischemic stroke, secondary stroke prevention relies on antiplatelet therapy unless anticoagulation is indicated. Aspirin has the largest evidence base and reduces the risk of early recurrent ischemic stroke without a major risk of early hemorrhagic complications.1 Because antiplatelet therapy typically continues for many years, clinicians and patients need an estimation of the annual bleeding risk to accurately assess future risk. In a meta-analysis of 25 randomized trials of antiplatelet therapy in primary or secondary prevention of cardiovascular disease, aspirin increased the abs...
Source: Neurology - August 28, 2017 Category: Neurology Authors: Lemmens, R., Al-Shahi Salman, R. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology, Infarction EDITORIALS Source Type: research

Magnesium, hemostasis, and outcomes in patients with intracerebral hemorrhage
Conclusions: These data support the hypothesis that magnesium exerts a clinically meaningful influence on hemostasis in patients with ICH.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Liotta, E. M., Prabhakaran, S., Sangha, R. S., Bush, R. A., Long, A. E., Trevick, S. A., Potts, M. B., Jahromi, B. S., Kim, M., Manno, E. M., Sorond, F. A., Naidech, A. M., Maas, M. B. Tags: All Cerebrovascular disease/Stroke, Critical care, Intracerebral hemorrhage ARTICLE Source Type: research

Long-term antithrombotic treatment in intracranial hemorrhage survivors with atrial fibrillation
Conclusions: In observational studies, anticoagulation with VKA is associated with a lower rate of IS than APA or no-ATM without increasing ICH recurrence significantly. A randomized controlled trial is needed to determine the net clinical benefit of anticoagulation in ICH survivors with AF.
Source: Neurology - August 14, 2017 Category: Neurology Authors: Korompoki, E., Filippidis, F. T., Nielsen, P. B., Del Giudice, A., Lip, G. Y. H., Kuramatsu, J. B., Huttner, H. B., Fang, J., Schulman, S., Marti-Fabregas, J., Gathier, C. S., Viswanathan, A., Biffi, A., Poli, D., Weimar, C., Malzahn, U., Heuschmann, P., Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Cardiac, Embolism, Intracerebral hemorrhage ARTICLE Source Type: research

Teaching NeuroImages: Artery of Percheron aneurysm masquerading as ICH spot sign
A 50-year-old Japanese woman presented with left thalamic intracerebral hemorrhage (ICH). CT angiography demonstrated an ICH spot sign and intracranial vasculopathy consistent with Moyamoya disease (figure 1). Conventional angiography demonstrated that the spot sign was actually a pseudoaneurysm arising from the artery of Percheron (figure 2). Intracranial aneurysms may complicate Moyamoya disease and occur at the circle of Willis, distal peripheral arteries, or Moyamoya vessels at a ratio of 3:1:1.1 Aneurysms in thalamo-perforating arteries are rare2 and an artery of Percheron aneurysm in Moyamoya disease has not been rep...
Source: Neurology - August 7, 2017 Category: Neurology Authors: Moughamian, A. J., Morshed, R. A., Colorado, R. A., Liner, Z., Cooke, D., Hemphill, J. C. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage RESIDENT AND FELLOW SECTION Source Type: research

Blood pressure reduction and noncontrast CT markers of intracerebral hemorrhage expansion
Conclusions: NCCT signs reliably identify ICH patients at high risk of hematoma growth. However, we found no evidence that patients with these markers specifically benefit from intensive BP reduction. Clinicaltrials.gov identifier: NCT01176565.
Source: Neurology - August 7, 2017 Category: Neurology Authors: Morotti, A., Boulouis, G., Romero, J. M., Brouwers, H. B., Jessel, M. J., Vashkevich, A., Schwab, K., Afzal, M. R., Cassarly, C., Greenberg, S. M., Martin, R. H., Qureshi, A. I., Rosand, J., Goldstein, J. N., On behalf of ATACH-II and NETT investigators Tags: CT, All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

Severity assessment in maximally treated ICH patients: The max-ICH score
Conclusions: Care limitations significantly influenced the validity of common prognostication models resulting in overestimation of poor outcome. The max-ICH score demonstrated increased predictive validity with minimized confounding by care limitations, making it a useful tool for severity assessment in ICH patients.
Source: Neurology - July 31, 2017 Category: Neurology Authors: Sembill, J. A., Gerner, S. T., Volbers, B., Bobinger, T., Lücking, H., Kloska, S. P., Schwab, S., Huttner, H. B., Kuramatsu, J. B. Tags: Other cerebrovascular disease/ Stroke, Prognosis, All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

Body mass index in early life and stroke in adult life: What is the risk?
The article "BMI increase through puberty and adolescence is associated with risk of adult stroke" by Ohlsson et al.1 explores the relationship between body mass index (BMI) when a person is young (adolescence) and risk of stroke when the person is older (adults). Previous studies2,3 have shown that rate of stroke is decreasing in older adults but increasing in younger adults. This finding coincides with an increasing BMI in children and young adults. The researchers wanted to ask: Does an increased BMI during puberty and adolescence increase the risk for stroke later in life? The authors also explored whether the cha...
Source: Neurology - July 24, 2017 Category: Neurology Authors: Jones, S. H., Karceski, S. C. Tags: Stroke prevention, Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Infarction, Intracerebral hemorrhage PATIENT PAGES Source Type: research

Adolescent weight gain confers long-term increased stroke risk: Weighty matters
Adult obesity has been consistently associated with risk of total, ischemic, and hemorrhagic stroke1–3; however, the degree to which change in weight and body mass index (BMI) during late childhood and adolescence affects adult risk of stroke has remained uncertain. Understanding this relationship is of particular importance given the rising obesity epidemic during childhood and adolescence.
Source: Neurology - July 24, 2017 Category: Neurology Authors: Rexrode, K. M., Kimm, S. Y. S. Tags: All Pediatric, Adolescence, Cohort studies, Infarction, Intracerebral hemorrhage EDITORIALS Source Type: research

Effects of increasing IV tPA-treated stroke mimic rates at CT-based centers on clinical outcomes
Conclusions: Thrombolysis of stroke mimics is increasing at our CT-based spoke hospitals and not at our MRI-based hub hospitals. Caution should be used in interpreting clinical outcomes based on large stroke databases when stroke diagnosis at discharge is unclear. Inadvertent reporting of treated stroke mimics as strokes will artificially elevate overall favorable clinical outcomes with additional downstream costs to patients and the health care system.
Source: Neurology - July 24, 2017 Category: Neurology Authors: Burton, T. M., Luby, M., Nadareishvili, Z., Benson, R. T., Lynch, J. K., Latour, L. L., Hsia, A. W. Tags: Outcome research, CT, MRI, DWI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Aggressiveness of care following intracerebral hemorrhage in women and men
Conclusions: After ICH, women do not receive less aggressive care than men after controlling for the substantial comorbidity differences. Future studies on sex bias should include the presence of comorbidities, prestroke disability, and other factors that may influence management.
Source: Neurology - July 24, 2017 Category: Neurology Authors: Guha, R., Boehme, A., Demel, S. L., Li, J. J., Cai, X., James, M. L., Koch, S., Langefeld, C. D., Moomaw, C. J., Osborne, J., Sekar, P., Sheth, K. N., Woodrich, E., Worrall, B. B., Woo, D., Chaturvedi, S. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

Comment: Does patient sex affect decision-making after hemorrhagic stroke?
Women do worse than men after both ischemic and hemorrhagic stroke, with evidence that sex bias in physician decision-making may contribute to this increased morbidity and mortality.1 Intracerebral hemorrhage (ICH) poses additional challenges, as the etiologies—amyloid angiopathy associated with prior cognitive decline, illicit drug use—carry their own assumptions. Guha et al.2 report findings from the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study, a prospective, multicenter, triethnic, case-control study of ICH risk factors and outcomes. In almost 3,000 people, they examined comorbidities,...
Source: Neurology - July 24, 2017 Category: Neurology Authors: Brodtmann, A. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

BMI increase through puberty and adolescence is associated with risk of adult stroke
Conclusions: BMI increase through puberty and adolescence is associated with risk of adult IS and ICH in men. We propose that greater BMI increases during puberty contribute to increased risk of adult stroke at least partly via increased blood pressure.
Source: Neurology - July 24, 2017 Category: Neurology Authors: Ohlsson, C., Bygdell, M., Sonden, A., Jern, C., Rosengren, A., Kindblom, J. M. Tags: All Pediatric, Adolescence, Cohort studies, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research

Imaging-based selection of patients for acute stroke treatment: Is it ready for prime time?
Historically, brain imaging in acute stroke has sought to exclude brain hemorrhage in order to allow therapy aiming at recanalization of the occluded intracranial artery. The National Institute of Neurological Disorders and Stroke study, published in 1995, found a clinical benefit of IV thrombolysis in acute stroke after exclusion of brain hemorrhage based on noncontrast CT (NCCT).1 More than 20 years later, the decision at most centers whether to give thrombolysis within the first 4.5 hours remains based on NCCT; often, the bolus of recombinant tissue plasminogen activator (rt-PA) is administered in the CT scanner suite e...
Source: Neurology - June 12, 2017 Category: Neurology Authors: Carrera, E., Wintermark, M. Tags: CT, MRI, Infarction EDITORIALS Source Type: research

Total small vessel disease score and risk of recurrent stroke: Validation in 2 large cohorts
Conclusions: The total SVD score has predictive value for recurrent stroke after TIA/ischemic stroke. Prediction of recurrence in patients with nonlacunar events highlights the potential role of SVD in wider stroke etiology.
Source: Neurology - June 12, 2017 Category: Neurology Authors: Lau, K. K., Li, L., Schulz, U., Simoni, M., Chan, K. H., Ho, S. L., Cheung, R. T. F., Küker, W., Mak, H. K. F., Rothwell, P. M. Tags: MRI, Prognosis, All Cerebrovascular disease/Stroke, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research