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Life‐threatening coronary disease is prevalent in patients with stenosing carotid artery disease
ConclusionsEndarterectomized carotid patients have a high risk of acute myocardial infarction and death, and need an intensified cardiovascular disease‐risk‐lowering treatment. Although asymptomatic, the evaluation of prognostically significant myocardial ischemia should be considered in these high‐risk patients. Eventually, a clinical trial is needed to address whether carotid patients would benefit from early intervention.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Krista Nuotio, Lauri Soinne, Helena Hänninen, Jani Saksi, Jarno Tuimala, Antti Jula, Petri T. Kovanen, Markku Kaste, Petra Ijäs, Perttu J. Lindsberg Tags: Research Source Type: research

Life ‐threatening coronary disease is prevalent in patients with stenosing carotid artery disease
ConclusionsEndarterectomized carotid patients have a high risk of acute myocardial infarction and death, and need an intensified cardiovascular disease‐risk‐lowering treatment. Although asymptomatic, the evaluation of prognostically significant myocardial ischemia should be considered in these high‐risk patients. Eventually, a clinical trial is needed to address whether carotid patients would benefit from early intervention.
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Krista Nuotio, Lauri Soinne, Helena H änninen, Jani Saksi, Jarno Tuimala, Antti Jula, Petri T. Kovanen, Markku Kaste, Petra Ijäs, Perttu J. Lindsberg Tags: Research Source Type: research

Carotid plaque inflammation assessed with 18F‐FDG PET/CT is higher in symptomatic compared with asymptomatic patients
Conclusion18F‐FDG uptake on PET/CT correlated with histological assessments of inflammation and was higher in patients with symptomatic compared with asymptomatic carotid artery plaques. These results support the use of 18F‐FDG PET/CT in the detection inflammation in carotid atherosclerosis, which may be of help in the detection of vulnerable plaques.
Source: International Journal of Stroke - January 15, 2015 Category: Neurology Authors: Karolina Skagen, Kjersti Johnsrud, Kristin Evensen, Helge Scott, Kirsten Krohg‐Sørensen, Frode Reier‐Nilsen, Mona‐Elisabeth Revheim, Jan Gunnar Fjeld, Mona Skjelland, David Russell Tags: Research Source Type: research

Prediction of recanalization in acute stroke patients receiving intravenous and endovascular revascularization therapy
ConclusionThe overall likelihood of recanalization was the highest in the endovascular group, and higher for intravenous thrombolysis compared with no revascularization therapy. However, our statistical models of recanalization for each individual patient indicate significant variability between treatment options, suggesting the need to include this prediction in the personalized treatment selection.
Source: International Journal of Stroke - June 30, 2014 Category: Neurology Authors: Guangming Zhu, Patrik Michel, Tudor Jovin, James T. Patrie, Wenjun Xin, Ashraf Eskandari, Weiwei Zhang, Max Wintermark Tags: Research Source Type: research

Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high‐risk carotid plaques
BackgroundPatients with symptomatic carotid artery stenosis are at high risk for recurrent stroke. To date, the decision to perform carotid endarterectomy in patients with a recent cerebrovascular event is mainly based on degree of stenosis of the ipsilateral carotid artery. However, additional atherosclerotic plaque characteristics might be better predictors of stroke, allowing for more precise selection of patients for carotid endarterectomy. Aims and hypothesisWe investigate the hypothesis that the assessment of carotid plaque characteristics with magnetic resonance imaging, multidetector‐row computed tomography angio...
Source: International Journal of Stroke - October 1, 2013 Category: Neurology Authors: M. T. B. Truijman, M. E. Kooi, A. C. Dijk, A. A. J. Rotte, A. G. Kolk, M. I. Liem, F. H. B. M. Schreuder, E. Boersma, W. H. Mess, R. J. Oostenbrugge, P. J. Koudstaal, L. J. Kappelle, P. J. Nederkoorn, A. J. Nederveen, J. Hendrikse, A. F. W. Steen, M. J. A Tags: Research Source Type: research