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A tennis lesson: sharp practice in the science behind the Sharapova case
Maria Sharapova (and hundreds of other elite athletes) took meldonium, a drug developed at the time of the USSR for the treatment of heart attack and stroke, though it has never been approved for use anywhere outside of the former Soviet Union. Meldonium is an inhibitor of -butyrobetaine hydroxylase, an enzyme involved in the carnitine biosynthetic pathway.1 Intake results in a reduction of tissue carnitine content, including the heart and skeletal muscles. Carnitine plays a critical role in transferring long-chain fatty acids across mitochondrial inner membrane into the mitochondrial matrix, to enable entry of the fatty a...
Source: Postgraduate Medical Journal - July 25, 2016 Category: Journals (General) Authors: Arduini, A., Zammit, V. A. Tags: Cardiomyopathy, Open access, Drugs: infectious diseases, Drugs: cardiovascular system, Epilepsy and seizures, Stroke, Interventional cardiology, Ischaemic heart disease, Diabetes, Metabolic disorders, Occupational and environmental medicine Editorials Source Type: research